
NCBI . NLM . NIH . GOV {
}
Title[redir]:
MicroRNA Targeting to Modulate Tumor Microenvironment - PMC
Description:
Communication between stromal cells and tumor cells initiates tumor growth, angiogenesis, invasion, and metastasis. Stromal cells include cancer-associated fibroblasts, tumor-associated macrophages, pericytes, endothelial cells, and infiltrating ...
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Keywords {🔍}
cells, tumor, google, scholar, doi, pubmed, cancer, pmc, article, mirna, free, delivery, cell, mirnas, microenvironment, cafs, fibroblasts, macrophages, microrna, stromal, expression, migration, angiogenesis, targeting, mira, growth, invasion, endothelial, breast, immune, cancerassociated, gene, mirb, micrornas, human, metastasis, tumorassociated, progression, systems, proliferation, vivo, pericytes, development, tams, levels, downregulated, nat, zhang, potential, pathways,
Topics {✒️}
pegylated liposome-polycation-hyaluronic acid pmc beta search caf-induced tumorigenic actions macrophage colony-stimulating factor improved circulating half-life vega-saenz de miera myeloid-derived suppressor cells α-smooth muscle actin seed-targeting tiny lnas microrna-26a suppresses recruitment patient-derived cafs reversed mir-30b/-30d correlates blood vessel morphology hypoxia-inducable factor-1α gap junction-mediated import stromal mir-200s contribute angiogenesis-related transcription factor tumor-infiltrating dendritic cells pro-inflammatory m1 macrophages hbv-positive hepatocellular carcinoma cell penetrating peptide cyclic rgd peptide aprpg–peg-modified liposomes mir-30b/30d regulation reduced post-transcriptional repression enforcing mir-511-3p expression tumor-suppressive mir-15a triple-negative breast cancer pro-tumorigenic properties pro-tumoral m2 immune cells mir-30d mir-149-/il-6-dependent manner m2 phenotype mir-511-3p publisher site pdf mir-34a resulted tumor growth mir-106b promotes tumor aggressiveness pro-tumorigenic potential pro-inflammatory tams mirna-responsive target genes peg chain bearing lung metastatic site plasma half-life ~1 similar toxicity issues mirna guide strand angiogenic endothelial cells surface-modified hk pro-tumoral genes murine xenograft glioblastoma viral-based delivery
Questions {❓}
- Can gap junctions deliver?
- In vivo gene delivery by nonviral vectors: overcoming hurdles?
- Up and down regulated miRNAs are enlisted?
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