
NCBI . NLM . NIH . GOV {
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Title[redir]:
A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells - PMC
Description:
Genital Chlamydia trachomatis (Ct) infection induces protective immunity that depends on interferon-γ producing CD4 T-cells. By contrast, mucosal exposure to ultraviolet light (UV)-inactivated Ct (UV-Ct) generated regulatory T-cells that exacerbated ...
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Keywords {🔍}
cells, doi, mice, uvct, mucosal, uterine, pubmed, google, scholar, uvctcsap, fig, memory, immunization, infection, cell, vaccination, pmc, challenge, day, free, article, protection, days, immunized, dcs, protective, group, genital, animals, experiments, teff, chlamydia, trm, trachomatis, circulating, burden, vaccine, response, weeks, uterus, biolegend, exposure, subsets, parabiosis, bacterial, naive, mucosa, micegroup, ctspecific, anticd,
Topics {✒️}
uv-ct–csap versus uv-ct charge-switching synthetic particles uv-ct–csap vaccination induced malt-derived ct-responsive teff graft-versus-host conditions uv-ct-csap vaccination generated emulsion-based manufacturing process mucosal uv-ct–csap vaccination foxp3-egfp+cd25+ nr1 cells intranasal uv-ct–csap vaccination nih grant p30-ai060354 cd45+mhc-ii+ apc subsets sjl ptprca pep3b/boyj subcutaneous uv-ct–csap vaccination tbs tissue-freezing liquid foxp3-egfp-depleted nr1 cells uv-ct persisted unabated tissue-specific homing receptors tissue-specific homing phenotypes csap-based mucosal vaccination long-lived resident memory enzyme-linked immunosorbent assays anti-mhc class ii pmc beta search uv-ct–csap leads resident memory t-cells phosphate-buffered l-lysine induces cross-serovar protection uv-ct conditioned donors tolerize mhc-ii−/− mice charge-switching particles 10ul anti-momp antibody generated regulatory t-cells elicited long-lived protection fewer ct-specific tn ct-specific protective memory infection-induced recruitment signals ct-derived genetic material steady-state signals remains gut-homing iga-secreting uv-ct accumulated preferentially circulating memory t-cells nih grants u54-ca119349 uv-ct–csap vaccination uv-ct induced tolerance uv-ct-induced tolerance uv-ct–csap failed sucrose-phosphate-glutamate media mucosa-resident cell types uv-ct-csap conjugates
Questions {❓}
- Intestinal CD103+ dendritic cells: master regulators of tolerance?
- What mechanisms are responsible for the differential T cell response to Ct or UV-Ct–cSAP versus UV-Ct?
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