Here's how DOI.ORG makes money* and how much!

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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Social Networks
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers
  13. CDN Services

We began analyzing https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.104.519702, but it redirected us to https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.104.519702. The analysis below is for the second page.

Title[redir]:
Genetic Analysis of the Interleukin-18 System Highlights the Role of the Interleukin-18 Gene in Cardiovascular Disease | Circulation
Description:
Background— Interleukin (IL)-18 plays a key role in atherosclerosis and its complications. The present study investigated the genetic variability of 4 genes of the IL-18 system—IL18, IL18R1, IL18RAP, and IL18BP—in relation to circulating IL-18 levels and cardiovascular mortality. Methods and Results— Twenty-two polymorphisms were genotyped in 1288 patients with coronary artery disease prospectively followed up during a median period of 5.9 years. The end point was death from cardiovascular causes (n=142). Baseline IL-18 levels were predictive of cardiovascular deaths occurring during ≤4 years of follow-up (HR=2.96, 95% CI 1.54 to 5.70, P=0.001 for the top compared with the bottom quartile) but not of later deaths. Haplotypes of the IL18 gene were associated with IL-18 levels (P=0.002) and cardiovascular mortality (P=0.006) after adjustment for cardiovascular risk factors. The same haplotype was associated with both a 9% lowering effect on IL-18 levels and a protective effect on risk (HR=0.57, 95% CI 0.36 to 0.92). IL18 haplotypes explained only 2% of IL-18 variability. Adjustment for baseline IL-18 levels abolished the association of haplotypes with cardiovascular risk. The haplotype associated with phenotypes was the only one carrying the minor allele of the IL18/A+183G polymorphism located in the 3′untranslated region and potentially affecting mRNA stability. The other genes of the system were not related to IL-18 levels or cardiovascular outcome. Conclusion— Variations of the IL18 gene consistently influence circulating levels of IL-18 and clinical outcome in patients with coronary artery disease, which supports the hypothesis of a causal role of IL-18 in atherosclerosis and its complications.

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌍 Impressive Traffic: 500k - 1M visitors per month


Based on our best estimate, this website will receive around 600,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

We see no obvious way the site makes money.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Doi.org might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

polymorphisms, levels, cardiovascular, gene, association, mainz, paris, crossref, haplotype, study, analysis, pubmed, haplotypes, google, scholar, genes, figure, view, baseline, medicine, circulation, patients, followup, risk, johannes, gutenberguniversity, france, ilr, polymorphism, department, germany, inserm, faculte, medecine, pitiesalpetriere, interleukin, disease, universite, pierre, marie, curie, dat, cek, hjr, genetic, years, articles, author, ilrap, mortality,

Topics {✒️}

supplemental material file etude cas-témoin de aha/asa scientific statements share previous article pro-inflammatory interleukins il-17 org/cgi/content/full/circulationaha supplements download pdf carman nga-man cheung large population-based cohort ana bárbara garcía-garcía signal-transducing β chain long-term prognosis general genetic model heart failure stroke additional tables author christine espinola-klein author thomas münzel american heart association introducing terms james chung-man ho latex particle–enhanced immunoassay investigación en arteriosclerosis johannes gutenberg–university mainz johannes gutenberg-university mainz allele-specific oligonucleotide hybridization red ™ aha coronary heart disease submit francisco javier ampudia-blasco high-affinity complex required references main content advertisement discussion acknowledgments footnote international users arteriosclerosis genetic diversity haplotype-based regression analysis author hans-jurgen rupprecht figures investigate high-order interactions atherosclerotic lesion development information criterion author françois cambien ethics committee apolipoprotein-e-deficient mice author david-alexandre tregouet haplotype-based association analysis african american origins atherogene control population

Social Networks {👍}(10)

External Links {🔗}(263)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Tag Manager

Libraries {📚}

  • Animate.css
  • Dropzone.js
  • Swiper
  • Typed.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Cookielaw

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