
NCBI . NLM . NIH . GOV {
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Title[redir]:
Multiple Molecular Subtypes of Triple-Negative Breast Cancer Critically Rely on Androgen Receptor and Respond to Enzalutamide In Vivo - PMC
Description:
Triple-negative breast cancer (TNBC) has the lowest 5-year survival rate of invasive breast carcinomas, and currently there are no approved targeted therapies for this aggressive form of the disease. The androgen receptor (AR) is expressed in up to ...
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Keywords {🔍}
doi, tnbc, cancer, enzalutamide, breast, cell, pubmed, google, scholar, fig, expression, proliferation, lines, areg, pmc, receptor, androgen, article, cells, subtypes, sumpt, molecular, free, migration, patients, hcc, invasion, tumor, knockdown, significantly, apoptosis, control, supplementary, decreased, nuclear, staining, treatment, dht, cellular, therapy, compared, study, assays, treated, lar, nonlar, inhibition, xenografts, bicalutamide, data,
Topics {✒️}
supplementary material nihms700660-supplement-supplement_1 supplementary materials nihms700660-supplement-supplement_1 end-stage metastases found luciferase-tagged hcc1806-tgl cells triple-negative breast cancer anti-egfr antibody cetuximab 1309/42f0-0d0d-jd0j-5edt quantitative real-time pcr sfg-nes-tgl vector pmc beta search additional ar-regulated genes mda-mb-453 cell lines generation anti-androgen enzalutamide multiple hormone-related malignancies mol cancer ther breast cancer metastasis mapk signaling pathway athymic nu/nu mice breast cancer metastases hormone receptor–targeted therapies metastatic breast cancer methods cell culture serum-free conditions long-term clinical benefit metastatic prostate cancer primary target genes full-length ar hormone receptor–negative mammary ductal morphogenesis identical serum-starved conditions mol cell endocrinol normal breast tissue attractant-free conditions ar nuclear localization breast cancer including breast cancer progression ar-regulated gene secondary antibody incubation rescues decreased proliferation decreases cellular viability advanced prostate cancer breast cancer subtypes anchorage-independent growth targeting androgen receptor ar-regulated genes shrnas targeting ar breast cancer res er+ breast cancer nuclear–cytoplasmic fractionation androgen receptor signaling
Questions {❓}
- Androgen receptor (AR) expression in 400 breast carcinomas: is routine AR assessment justified?
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