
NCBI . NLM . NIH . GOV {
}
Title[redir]:
International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma - PMC
Description:
Adenocarcinoma is the most common histologic type of lung cancer. To address advances in oncology, molecular biology, pathology, radiology, and surgery of lung adenocarcinoma, an international multidisciplinary classification was sponsored by the ...
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Keywords {π}
doi, lung, google, scholar, adenocarcinoma, pubmed, cancer, cell, carcinoma, adenocarcinomas, egfr, patients, invasive, tumor, small, mucinous, molecular, tumors, mutations, histologic, growth, clinical, pathol, classification, mutation, solid, squamous, clin, pmc, features, study, ais, lepidic, oncol, survival, article, thorac, diagnosis, bronchioloalveolar, bac, gene, free, studies, prognostic, cells, nonsmall, multiple, pattern, versus, nonmucinous,
Topics {βοΈ}
tumor fluoro-2-deoxy-d-glucose avidity formalin-fixed paraffin-embedded tissue bronchoscopy/navigation-assisted bronchoscopy proposed iaslc/ats/ers classification video-assisted thoracic surgery braf-v600e-mutated lung adenocarcinoma video-assisted thoracoscopic surgery 1309/550p-qljx-d84w-f6dn 1309/chxa-3mh0-b7fd-jgul 1309/cm20-wa20-rw3t-600l 1309/u4wg-e9eb-fjn6-cm8r 1309/p5ab-r5kq-89rn-jtfh 1309/umf7-15kr-g2v1-98yd k-ras gene-mutation analyses diastase-periodic acid schiff ground-glass opacity nodules author reply e3βe4 pulmonary ground-glass opacity pure ground-glass opacity localized ground-glass attenuation ground-glass versus solid alk-rearranged lung adenocarcinomas ground-glass opacity selected pulmonary ground-glass nodules majority ground-glass attenuation23 predominant ground-glass component eml4-alk-positive lung adenocarcinoma signet-ring cell carcinoma estimating long-term effectiveness high-resolution computed tomography endobronchial ultrasound-guided tbna eml4-alk fusion gene thin-section computed tomographic high-resolution ct scan somatic k-ras mutations thin-section computed tomography k-ras oncogene activation iaslc/ats/ers criteria ct-guided biopsy needle iaslc/ats/ers classification pmc copyright notice potential life-threatening hemorrhage pulmonary intestinal-type adenocarcinoma ground-glass opacity found thin-section ct technique taxane-based neoadjuvant chemotherapy small-cell lung carcinoma small-cell lung cancers small-cell lung cancer predicts long-term survival
Questions {β}
- , TTF-1 and/or p63) versus conventional light microscopy alone which is the basis for current data?
- , relative extent of ground glass versus solid components) for each nodule assist in the determination whether the nodules are metastases versus synchronous or metachronous primary carcinomas, similar to the way comprehensive histologic subtyping is helpful pathologically?
- 5 cm the best size cut off?
- Are we coming full circle for lung cancer screening a second time?
- Can CT be Used to Select Patients for Sublobar Resection?
- Do tumors that meet criteria for MIA have 100% disease-free survival if the invasive component is predominantly solid, micropapillary or if they show giant cell and spindle cell components that fail to qualify for a diagnosis pleomorphic carcinoma?
- Does the micropapillary pattern have a similar poor prognostic significance in advanced stage and early stage?
- Evaluation of patients with pulmonary nodules: when is it lung cancer?
- Has Cox-2 a prognostic role in non-small-cell lung cancer?
- How can this histological and/or molecular classification improve our ability to estimate prognosis and optimize the selection of patients for a specific therapy?
- How can this new classification impact CT screening?
- How should tumor size be measured: single largest diameter, bidimensional, volume?
- In metastatic lung adenocarcinomas, what are the clinical implications of any potential differences in molecular or histologic features compared with primary tumors?
- In particular, how should the lepidic pattern be distinguished from other invasive patterns such as acinar and papillary?
- In specimens from metastatic sites, is there any clinical significance to recognizing histologic patterns, including the predominant pattern?
- Is Sublobar (Limited) Resection Adequate Oncologic Treatment for Some Early Adenocarcinomas?
- Is There a Difference in Outcome between Video-Assisted Thoracoscopic surgery versus Thoracotomy in the Treatment of Early-Stage Lung Adenocarcinoma?
- Is immunohistochemical testing using EGFR mutation-specific antibodies a reliable method for predicting the presence of an EGFR mutation?
- Is immunohistochemical testing using EGFR mutation-specific antibodies as predictive of response to EGFRTKIs as EGFR mutations?
- Is there any prognostic significance to the aggressive micropapillary or solid components when present in relatively small amounts if they do not represent the predominant pattern?
- Persistent questions include what is the optimal method for measuring the size of the invasive component?
- Pulmonary nodular ground-glass opacities in patients with extrapulmonary cancers: what is their clinical significance and how can we determine whether they are malignant or benign lesions?
- Should a Systematic Lymph Node Dissection be Performed in Every Early-Stage Adenocarcinoma?
- Signet ring cell features (SRCF) in lung adenocarcinoma: a cytologic feature or a histologic subtype?
- What are the clinical, epidemiological, molecular, and histologic characteristics of never smokers with lung adenocarcinoma?
- What can be Expected of Pathologists at Frozen Section?
- What is the CT attenuation according to the newly proposed lung adenocarcinoma histologic subtypes?
- What is the long-term follow-up for completely resected solitary mucinous MIA?
- What is the natural history of single and multiple GGNs?
- What is the relative importance of histologic versus molecular data for identifying prognostic or predictive markers based on small biopsies and cytology versus resected specimens?
- What is βquality of evidenceβ and why is it important to clinicians?
- What molecular correlations can be made with the spectrum of radiologic patterns of lung adenocarcinoma?
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