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  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
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We began analyzing https://link.springer.com/article/10.1007/s004150050275, but it redirected us to https://link.springer.com/article/10.1007/s004150050275. The analysis below is for the second page.

Title[redir]:
Immunocompetence of human microvascular brain endothelial cells: cytokine regulation of IL-1β, MCP-1, IL-10, sICAM-1 and sVCAM-1 | Journal of Neurology
Description:
Endothelia from the brains of four patients undergoing neurosurgery, including one multiple sclerosis (MS) patient, were studied in vitro to determine cytokine and chemokine production; the release of soluble adhesion molecules was also investigated. The same procedure was repeated on human umbilical vein endothelial cells (HUVECs) in order to detect possible district-specific differences. After isolation, the endothelium was cultured and stimulated with γ-interferon (IFN), tumour necrosis factor alpha (TNF-α) and LPS. The results showed that brain endothelium, in our experimental conditions, does not produce interleukin (IL)-10 and produces lower amounts of IL-1β and soluble intercellular adhesion molecule-1 (sICAM-1) than HUVECs do; no differences were detected in soluble vascular cell adhesion molecule-1 (sVCAM-1) production. MCP-1 mRNA was detected both without and after stimulation with TNF-α and γ-IFN in HUVECs and MS human brain endothelial cells (HBECs), while in non-MS-HBECs it was found only after γ-IFN stimulation.

Matching Content Categories {📚}

  • Telecommunications
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  • Politics

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,904,851 visitors per month in the current month.

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We find it hard to spot revenue streams.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

article, cells, access, brain, endothelial, privacy, cookies, content, journal, human, information, publish, search, ilβ, mcp, open, data, log, research, microvascular, cytokine, sicam, svcam, frigerio, gelati, ciusani, soluble, adhesion, huvecs, endothelium, tnfα, interleukin, discover, springer, optional, personal, including, parties, policy, find, track, neurology, immunocompetence, regulation, cite, corsini, dufour, massa, salmaggi, explore,

Topics {✒️}

month download article/chapter il-1β differentially regulate related subjects full article pdf privacy choices/manage cookies brain endothelium soluble adhesion molecules district-specific differences produce interleukin check access instant access european economic area scope submit manuscript patients undergoing neurosurgery produces lower amounts pro-trophic phenotype pro-inflammatory tnfα conditions privacy policy accepting optional cookies multiple sclerosis journal finder publish article journal article log γ-ifn stimulation article cite il-1β article frigerio privacy policy personal data mcp-1 mrna books a optional cookies manage preferences vitro inflammatory phenotype journal publish subscription content similar content data protection essential cookies cookies skip neurology aims experimental conditions institution subscribe γ-interferon γ-ifn anti-inflammatory endothelium information ms-hbecs

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Immunocompetence of human microvascular brain endothelial cells: cytokine regulation of IL-1β, MCP-1, IL-10, sICAM-1 and sVCAM-1
         description: Endothelia from the brains of four patients undergoing neurosurgery, including one multiple sclerosis (MS) patient, were studied in vitro to determine cytokine and chemokine production; the release of soluble adhesion molecules was also investigated. The same procedure was repeated on human umbilical vein endothelial cells (HUVECs) in order to detect possible district-specific differences. After isolation, the endothelium was cultured and stimulated with γ-interferon (IFN), tumour necrosis factor alpha (TNF-α) and LPS. The results showed that brain endothelium, in our experimental conditions, does not produce interleukin (IL)-10 and produces lower amounts of IL-1β and soluble intercellular adhesion molecule-1 (sICAM-1) than HUVECs do; no differences were detected in soluble vascular cell adhesion molecule-1 (sVCAM-1) production. MCP-1 mRNA was detected both without and after stimulation with TNF-α and γ-IFN in HUVECs and MS human brain endothelial cells (HBECs), while in non-MS-HBECs it was found only after γ-IFN stimulation.
         datePublished:
         dateModified:
         pageStart:727
         pageEnd:730
         sameAs:https://doi.org/10.1007/s004150050275
         keywords:
            Key words Brain endothelium
            IL-1 beta
            IL-10
            MCP-1
            Neurology
            Neurosciences
            Neuroradiology
         image:
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            name:Journal of Neurology
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                        name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
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                        name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
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                     address:
                        name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
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                     name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
                     address:
                        name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
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                        name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
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                        name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
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                     name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
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                        name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
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ScholarlyArticle:
      headline:Immunocompetence of human microvascular brain endothelial cells: cytokine regulation of IL-1β, MCP-1, IL-10, sICAM-1 and sVCAM-1
      description: Endothelia from the brains of four patients undergoing neurosurgery, including one multiple sclerosis (MS) patient, were studied in vitro to determine cytokine and chemokine production; the release of soluble adhesion molecules was also investigated. The same procedure was repeated on human umbilical vein endothelial cells (HUVECs) in order to detect possible district-specific differences. After isolation, the endothelium was cultured and stimulated with γ-interferon (IFN), tumour necrosis factor alpha (TNF-α) and LPS. The results showed that brain endothelium, in our experimental conditions, does not produce interleukin (IL)-10 and produces lower amounts of IL-1β and soluble intercellular adhesion molecule-1 (sICAM-1) than HUVECs do; no differences were detected in soluble vascular cell adhesion molecule-1 (sVCAM-1) production. MCP-1 mRNA was detected both without and after stimulation with TNF-α and γ-IFN in HUVECs and MS human brain endothelial cells (HBECs), while in non-MS-HBECs it was found only after γ-IFN stimulation.
      datePublished:
      dateModified:
      pageStart:727
      pageEnd:730
      sameAs:https://doi.org/10.1007/s004150050275
      keywords:
         Key words Brain endothelium
         IL-1 beta
         IL-10
         MCP-1
         Neurology
         Neurosciences
         Neuroradiology
      image:
      isPartOf:
         name:Journal of Neurology
         issn:
            1432-1459
            0340-5354
         volumeNumber:245
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:S. Frigerio
            affiliation:
                  name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
                  address:
                     name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. Gelati
            affiliation:
                  name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
                  address:
                     name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
                     type:PostalAddress
                  type:Organization
            type:Person
            name:E. Ciusani
            affiliation:
                  name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
                  address:
                     name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
                     type:PostalAddress
                  type:Organization
            type:Person
            name:E. Corsini
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                  name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
                  address:
                     name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
                     type:PostalAddress
                  type:Organization
            type:Person
            name:A. Dufour
            affiliation:
                  name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
                  address:
                     name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
                     type:PostalAddress
                  type:Organization
            type:Person
            name:G. Massa
            affiliation:
                  name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
                  address:
                     name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
                     type:PostalAddress
                  type:Organization
            type:Person
            name:A. Salmaggi
            affiliation:
                  name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
                  address:
                     name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
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      name:Journal of Neurology
      issn:
         1432-1459
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      volumeNumber:245
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      name:Springer-Verlag
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         type:ImageObject
      name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
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         name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
         type:PostalAddress
      name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
      address:
         name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
         type:PostalAddress
      name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
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         name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
         type:PostalAddress
      name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
      address:
         name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
         type:PostalAddress
      name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
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         name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
         type:PostalAddress
      name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
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         name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
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            address:
               name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
               type:PostalAddress
            type:Organization
      name:M. Gelati
      affiliation:
            name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
            address:
               name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
               type:PostalAddress
            type:Organization
      name:E. Ciusani
      affiliation:
            name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
            address:
               name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
               type:PostalAddress
            type:Organization
      name:E. Corsini
      affiliation:
            name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
            address:
               name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
               type:PostalAddress
            type:Organization
      name:A. Dufour
      affiliation:
            name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
            address:
               name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
               type:PostalAddress
            type:Organization
      name:G. Massa
      affiliation:
            name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
            address:
               name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
               type:PostalAddress
            type:Organization
      name:A. Salmaggi
      affiliation:
            name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217
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               name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
               type:PostalAddress
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      name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
      name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
      name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
      name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
      name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
      name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
      name:Istituto Nazionale Neurologico “C. Besta”, Via Celoria, 11, I-20133 Milan, Italy Tel.: +39-2-2394348 Fax: +39-2-70638217, , IT
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