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Title[redir]:
Stretch-Enhancers Delineate Disease-Associated Regulatory Nodes in T Cells - PMC
Description:
Enhancers regulate spatiotemporal gene expression and impart cell-specific transcriptional outputs that drive cell identity1. Stretch- or super-enhancers (SEs) are a subset of enhancers especially important for genes associated with cell identity ...
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Keywords {🔍}
ses, genes, cells, cell, doi, data, figure, bach, extended, fig, gene, binding, pmc, tes, transcription, snps, article, genomic, regions, pubmed, google, scholar, free, rnaseq, expression, table, risk, based, spikedin, tofacitinib, pii, nature, test, enrichment, enhancers, wildtype, human, number, enriched, calculated, genome, chipseq, stat, analysis, disease, seassociated, domains, ncrnas, levels, rna,
Topics {✒️}
�htseq-count --mode=intersection-nonempty --stranded= =``\htseq-count --mode=intersection-nonempty --stranded= plate-bound anti-cd3/anti-cd28 wilcoxon rank-sum test genome-wide meta-analysis increases wilcoxon signed-rank test anti α-cd3 antibody p-values kolmogorov-smirnov test high-performance computational capabilities 326e-07 kolmogorov-smirnov test distinguished highly lineage-specific 5ng/ml rhtgf-β pmc beta search 5μg/ml α-cd3 rna-seq-tag-enriched islands cell-mediated immune mechanisms prepare rna-seq libraries kolmogorov-smirnov test p bach2ko rna-seq data employed chip-seq datasets column-based dna removal bach2-dependent noncoding rnas normalize chip-seq libraries rna-seq datasets generated lineage-predicting transcription factors lineage-specific transcription factors t-bet transcriptome data bach2-deficient rna-seq rna-seq libraries shown genes encoding t-bet bach2 chip-seq data define cell type-specific treated rna-seq data united states government p-values permutations test establishing chromatin accessibility mediator establish super-enhancers large-scale association analysis including rheumatoid arthritis naïve cd4+cd45ra+cd45ro− drive cell identity1 total read count kolmogorov-smirnov test th17-specific se regions cell-type specific ses cell type-specific ses th17-specific se genes mediated immune homeostasis se-versus te-genes supplementary materials included
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