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cell, receptors, natural, killer, mandelboim, cas, pubmed, google, scholar, inhibitory, article, privacy, cookies, content, information, publish, research, protocol, chapter, human, search, protocols, methods, gazit, activating, cells, nkp, receptor, immunol, strominger, data, log, journal, ligands, lankry, humans, major, access, reyburn, press, springer, site, function, optional, media, personal, parties, protection, policy, find,

Topics {✒️}

springer science+business media natural killer cells nk-activating receptor kir2ds4 natural cytotoxic receptors nk cell receptors cell surface receptors privacy choices/manage cookies inhibitory surface receptors human leukocyte antigen humana press journal finder publish european economic area cellular immune responses collectively named ncrs c-type lectin n-linked carbohydrate conditions privacy policy protocol lankry cancer research accepting optional cookies main content log online nk cells killer ig research tools protocol cite journal publish receptor superfamily mhc proteins chapter introduces receptor proteins chapter log ligands protocol privacy policy personal data major families check access ethics access campbell rights permissions reprints books a human cd16 optional cookies social media manage preferences multiple activating information essential cookies cookies skip subscription content

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ScholarlyArticle:
      headline:Methods to Identify and Characterize Different NK Cell Receptors and Their Ligands
      pageEnd:273
      pageStart:249
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-60761-362-6.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:Natural Killer Cell Protocols
         isbn:
            978-1-60761-362-6
            978-1-60761-361-9
         type:Book
      publisher:
         name:Humana Press
         logo:
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            type:ImageObject
         type:Organization
      author:
            name:Dikla Lankry
            affiliation:
                  name:The Hebrew University - Hadassah Medical School
                  address:
                     name:The Hebrew University - Hadassah Medical School, Jerusalem, Israel
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Roi Gazit
            affiliation:
                  name:The Hebrew University - Hadassah Medical School
                  address:
                     name:The Hebrew University - Hadassah Medical School, Jerusalem, Israel
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ofer Mandelboim
            affiliation:
                  name:The Hebrew University - Hadassah Medical School
                  address:
                     name:The Hebrew University - Hadassah Medical School, Jerusalem, Israel
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:NK cell clones, Ig-fused proteins, BW assay, cytotoxicity assays, point mutations
      description:Different cellular immune responses are modulated by the cross talk between activating and inhibitory signaling pathways initiated via different cell surface receptors. Similarly, the killing of NK cells is controled by multiple activating and inhibitory surface receptors. In humans, the major NK triggering receptors, identified so far, include NKp80, 2B4 NKG2D, and CD16 and the natural cytotoxic receptors (collectively named NCRs) include NKp46, NKp44, and NKp30. The two major families of MHC-specific inhibitory receptors identified in humans are the Ig superfamily (KIR and LIR) and the C-type lectin (CD94/NKG2A) receptor superfamily. The different inhibitory receptors show diverse specificity and discriminate between different class I MHC proteins. Much is known about the function and expression patterns of the different NK cell receptors, but the ligand identity of several of the activating NK cell receptors is yet to be discovered. This chapter introduces several research tools that can be used to uncover the identities of different ligands for NK cell receptors.
      datePublished:2010
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      isbn:
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         978-1-60761-361-9
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      name:Humana Press
      logo:
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      name:The Hebrew University - Hadassah Medical School
      address:
         name:The Hebrew University - Hadassah Medical School, Jerusalem, Israel
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      name:Dikla Lankry
      affiliation:
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            address:
               name:The Hebrew University - Hadassah Medical School, Jerusalem, Israel
               type:PostalAddress
            type:Organization
      name:Roi Gazit
      affiliation:
            name:The Hebrew University - Hadassah Medical School
            address:
               name:The Hebrew University - Hadassah Medical School, Jerusalem, Israel
               type:PostalAddress
            type:Organization
      name:Ofer Mandelboim
      affiliation:
            name:The Hebrew University - Hadassah Medical School
            address:
               name:The Hebrew University - Hadassah Medical School, Jerusalem, Israel
               type:PostalAddress
            type:Organization
PostalAddress:
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      name:The Hebrew University - Hadassah Medical School, Jerusalem, Israel
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