
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Mitochondrial reactive oxygen species and cancer - PMC
Description:
Mitochondria produce reactive oxygen species (mROS) as a natural by-product of electron transport chain activity. While initial studies focused on the damaging effects of reactive oxygen species, a recent paradigm shift has shown that mROS can act ...
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Keywords {🔍}
doi, ros, pubmed, google, scholar, cancer, cells, cell, pmc, mitochondrial, free, article, signaling, oxygen, mros, shown, mutations, complex, increased, production, increase, tumor, reactive, antioxidant, hifα, activation, levels, antioxidants, species, growth, nrf, hydrogen, peroxide, pathway, tumorigenesis, activity, expression, hypoxia, nadph, loss, cellular, biol, proteins, stress, superoxide, factor, nature, chandel, inhibit, protein,
Topics {✒️}
b-raf-induced lung cancer p53-mediated cell-cycle arrest fh-deficient cells succinates pro-tumorigenic signaling pathways pmc beta search reactive oxygen species p66shc-dependent signaling pathway hypoxia-inducible factors amplify ros-dependent signaling activate pro-growth responses hypoxia-inducible factor anti-invasive adjuvant therapy fh-null cancer cells hif-dependent antitumorigenic effect antioxidant n-acetyl cysteine hypoxia-induced ros production reactive nitrogen species mitochondrial transcription factor phosphoinositide-dependent kinase-1 hypoxia-sensitive α subunits understand ros-targeted pathways nadph oxidase-independent production oncogene-induced genetic instability small-cell lung cancer increase colony formation complex iii-derived ros c-myc potentiate apoptosis ros-mediated signaling targets license information pmcid regulate cellular proliferation phosphoinositide 3-kinase pathway nrf2-keap1 signaling pathway increase glycolytic flux p53-mediated tumor suppression cellular oxygen sensing k-rasg12d pyruvate dehydrogenase kinase modulates mitochondrial function renal cyst formation fh-null cells growth factor stimulation epidermal growth factor mitochondrial-targeted antioxidants blocks ros detoxification reactions hypoxic hif-alpha activation pyruvate kinase m2 diminished oxygen microenvironment transcription factor required nih grants ro1ca123067 mitochondrial-derived ros
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