
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Mycophenolic Acid Differentially Impacts B Cell Function Depending on the Stage of Differentiation - PMC
Description:
Production of pathogenic Abs contributes to disease progression in many autoimmune disorders. The immunosuppressant agent mycophenolic acid (MPA) has shown clinical efficacy for patients with autoimmunity. The goal of these studies was to elucidate ...
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Keywords {🔍}
cells, mpa, cell, doi, pcs, fig, data, pubmed, google, scholar, expression, production, shown, activation, impdh, day, culture, differentiation, primary, effect, concentrations, isolated, human, inhibition, activated, patients, stimulated, stimulation, total, anticd, presence, mycophenolate, mofetil, purified, cpgb, expansion, cultures, cycle, differentiated, reduced, inhibits, terminally, cytokine, added, inhibited, lupus, blood, apoptosis, ilanticdantiigm, mycophenolic,
Topics {✒️}
anti-cd3/anti-cd28–coated beads il-21/anti-cd40/anti-igm maximally activated anti-cd3/anti-cd28 beads anti-cd3/anti-cd28 microbeads supplementary material nihms629090-supplement-supplement_1 inosine monophosphate dehydrogenase anti-cd3/anti-cd28–activated cd4+ germinal center supplementary materials nihms629090-supplement-supplement_1 il-21/anti-cd40/anti-igm induced il-21/anti-cd40/anti-igm resulted sle-prone mrllpr/lpr mice anti-cd3/anti-cd28–stimulated article footnotes references il-21/anti-cd40/anti-igm stimulation anti-inflammatory il-1r antagonist impdh expression/real-time pcr x-vivo-15 serum-free medium anti-cd3/anti-cd28 il-21/anti-cd40/anti-igm il-21r–fc consistently inhibits systemic lupus erythematosus cd19loigd−cd38hi ab-secreting pcs long-lived ig-secreting pcs anti-dsdna ab titers antibody-secreting plasma cells anti-cd3–coated plates goat anti-human igm− mrl lpr/lpr mice mrl-lpr/lpr mice anti-dna antibody induction post-sort pc fractions reduce hla-specific asc tram1 anti-cd40l mab pmc beta search potent anti-inflammatory properties pmc copyright notice rheumatoid arthritis significant dose-dependent decrease long-lived pcs contribute regulating b-cell function anti-dsdna titers mitomycin c-treated cd4+ mycophenolic acid activation serum-free media anti-cd40 mab class switch recombination proinflammatory cytokine il-1β prevented plasma cell cell-induced pc differentiation
Questions {❓}
- B-cell-depletion therapy in SLE—what are the current prospects for its acceptance?
- What is the value of mycophenolate mofetil as induction and maintenance therapy in lupus nephritis?
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