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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://www.ahajournals.org/doi/10.1161/ATVBAHA.112.300263, but it redirected us to https://www.ahajournals.org/doi/10.1161/ATVBAHA.112.300263. The analysis below is for the second page.

Title[redir]:
Transintestinal Cholesterol Excretion Is an Active Metabolic Process Modulated by PCSK9 and Statin Involving ABCB1 | Arteriosclerosis, Thrombosis, and Vascular Biology
Description:
Objective—Transintestinal cholesterol excretion (TICE) is an alternate pathway to hepatobiliary secretion. Our study aimed at identifying molecular mechanisms of TICE. Approach and Results—We studied TICE ex vivo in mouse and human intestinal explants, and in vivo after bile diversion and intestinal cannulation in mice. We provide the first evidence that both low-density lipoprotein (LDL) and high-density lipoprotein deliver cholesterol for TICE in human and mouse jejunal explants at the basolateral side. Proprotein convertase subtilisin kexin type 9 (PCSK9)−/− mice and intestinal explants show increased LDL-TICE, and acute injection of PCSK9 decreases TICE in vivo, suggesting that PCSK9 is a repressor of TICE. The acute repression was dependent on the LDL receptor (LDLR). Further, TICE was increased when mice were treated with Lovastatin. These data point to an important role for LDLR in TICE. However, LDLR−/− mice showed increased intestinal LDL uptake, contrary to what is observed in the liver, and tended to have higher TICE. We interpret these data to suggest that there might be at least 2 mechanisms contributing to TICE; 1 involving LDL receptors and other unidentified mechanisms. Acute modulation of LDLR affects TICE, but chronic deficiency is compensated for most likely by the upregulation of the unknown mechanisms. Using mice deficient for apical multidrug active transporter ATP-binding cassette transporter B1 a and b, and its inhibitor, we show that these apical transporters contribute significantly to TICE. Conclusions—TICE is operative in human jejunal explants. It is a metabolically active process that can be acutely regulated, inversely related to cholesterolemia, and pharmacologically activated by statins.

Matching Content Categories {📚}

  • Health & Fitness
  • Education
  • Science

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 94,026,998 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Doi.org could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

tice, cholesterol, mice, france, ldlr, nantes, pcsk, crossref, figure, ldl, pubmed, google, scholar, umr, department, explants, excretion, lipoprotein, data, toulouse, apical, biology, increased, plasma, hdl, cell, measured, intestinal, receptor, vivo, inserm, transintestinal, liver, university, hospital, medical, center, hldl, minutes, suny, downstate, brooklyn, onlineonly, supplement, lowdensity, side, intestine, hcholesterol, article, group,

Topics {✒️}

atp-binding cassette family p2y13/ectof1-atp synthase pathway 3h-cholesterol–labeled low-density lipoprotein aha/asa scientific statements supplemental material file low-density lipoprotein receptor american heart association identified low-density lipoprotein low-density lipoprotein catabolism low-density lipoprotein remnants transintestinal 3h-cholesterol excretion scavenger receptor b1 large high-density lipoprotein scavenger receptor sr-bi cédric le low-density lipoprotein low-density lipoprotein low density lipoprotein significance atherosclerosis joan carles escolà-gil article thin-capped atheromata food research international transintestinal cholesterol excretion abcg5/g8 transporter heart failure stroke hepatic niemann-pick c1 authors contributed equally abcg5/g8 knockout mice high-density lipoprotein high density lipoprotein multidrug transporter abcb1 potential cholesterol-lowering drug methods material 3h-free cholesterol red ™ aha submit triglyceride-rich emulsion particles trans-intestinal cholesterol efflux multidrug-resistant p-glycoprotein coronary heart disease excrete plasma-derived ldl concentration-dependent passive process adenovirus-mediated gene delivery larger triglyceride-rich lipoproteins hepatic-biliary cholesterol secretion vascular biology vol 3h-cholesterol labeled ldl 3h-cholesterol–labeled ldl supplements download pdf fecal cholesterol excretion

Questions {❓}

  • How do these lipoproteins contribute to TICE?

Social Networks {👍}(11)

External Links {🔗}(312)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Tag Manager

Libraries {📚}

  • Animate.css
  • Dropzone.js
  • Swiper
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Cookielaw

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