
NCBI . NLM . NIH . GOV {
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Title[redir]:
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength - PMC
Description:
Adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists. This review by de Lau et al. focuses on the complex physical and functional interactions of three recently discovered protein ...
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Keywords {🔍}
lgr, google, scholar, doi, pubmed, wnt, rspondin, cells, cell, signaling, pmc, stem, van, free, article, receptor, receptors, development, domain, rnf, expression, gene, intestinal, mice, fig, rspondins, βcatenin, znrf, proteins, furin, complex, family, wang, genes, interaction, crypt, colon, lau, clevers, protein, rnfznrf, mouse, human, biol, peng, adult, activity, cancer, epithelium, mutations,
Topics {✒️}
oocyte-derived r-spondin appeared subsequent g-protein-driven elevation lgr4-mediated wnt/β-catenin signaling orphan g-protein-coupled receptor r-spondin/lgr5/rnf43 module appears g-protein-coupled receptor gpr49 vertebrate-specific wnt-agonists r-spondins c-terminal cysteine-rich caps high-affinity ligand-receptor pair β-catenin/tcf-4 complex imposes r-spondin/lgr-mediated enhancement free cytoplasmic β-catenin canonical wnt/β-catenin signaling vitro r-spondin-mediated rescue regulate wnt/β-catenin signaling r-spondin-driven wnt activation present-day r-spondin diversity wnt/tcf4-driven genetic program wnt–lgr/r-spondin signaling g-protein-coupled receptor 48 lgr5/r-spondin complex acts r-spondin/lgr5/rnf43 module stem-cell e3 ligase single-pass transmembrane proteins epithelial stem-cell compartments inducible cre-mediated control involve g-protein signaling hydrophobic r-spondin/lgr interface single-cell-layered barrier pmc beta search protein-coupled receptor gpr49 c-terminal cap modules c-terminally “embraced” arrangement lgr4/5 ecd–r-spondin complexes follicle-stimulating hormone receptor stem/progenitor cells contribute phospho-modified β-catenin protein-coupled receptors reveals entire crypt–villus axis respective receptor/ligand pairs β-catenin–tcf signaling wnt/β-catenin signaling mucous-secreting goblet cells protein-coupled receptor lgr2 fz/lrp receptor complex intestinal wnt/tcf signature nonsense-mediated mrna decay r-spondin proteins harbor thyroid-stimulating hormone receptor wnt-driven crypt program
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