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Title[redir]:
Hepatology
Description:
tor subfamily, which includes the thyroidâstimulating hormone receptor (TSHR). However, Gpr49 remains to be an orphan Gâproteinâcoupled receptor. By realâtime quantitative reverse transcriptase polymerase chain reaction (RTâPCR) analysis, overexpression (>3âfold increase compared with the corresponding noncancerous liver tissue) of Gpr49 mRNA was observed in 18 of 38 (47%) HCCs compared with corresponding noncancerous livers. Clinicopathologically, overexpression of Gpr49 was frequently observed in HCC with mutation in βâcatenin exon 3 (14 of 16 cases, 87.5%). Moreover, introduction of mutant βâcatenin into mouse hepatocytes in culture caused upâregulation of the Gpr49 mouse homologue. Therefore, Gpr49 is likely to be a target gene activated by Wntâsignaling in HCC. In conclusion, although much is still unknown, Gpr49 may be critically involved in the development of HCCs with βâcatenin mutations and has the potential to be a new therapeutic target in the treatment of HCC. * Pathology Division, National Cancer Center Research Institute, 5â1â1 Tsukiji, Chuoâku, Tokyo, 104â0045, Japan; fax: (81) 3â3248â2463; E-mail: [email protected]. Received: 15 March 2002; Accepted: 11 August 2002 Copyright Š 2003 American Association for the Study of Liver Diseases....
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Keywords {đ}
gpr, liver, aasld, hcc, log, journal, βcatenin, access, hepatology, subscribe, issue, alerts, member, abstract, overexpression, genes, receptor, register, logo, articles, browse, submit, article, orphan, gproteincoupled, human, hepatocellular, mutations, buy, hormone, compared, noncancerous, observed, hccs, mouse, target, copyright, american, association, study, diseases, text, subscribers, members, request, content, service, usa, privacy, policy,
Topics {âď¸}
thyroidâstimulating hormone receptor aasld members log primary liver cancer noncancerous liver tissue open access policy individual subscribers log βâcatenin mutations protein-coupled receptor proteinâcoupled receptor βâcatenin exon 3 mutant βâcatenin liver diseases institutional users access human hepatocellular carcinomas read abstracts ultrasensitive lc540449 reduced steatosis artificial intelligence training target gene activated full text access gpr49 mouse homologue journal tables register subscribe service request 800-638-3030 50029 buy abstract journal website subscribe hepatocellular carcinoma noncancerous livers mouse hepatocytes therapeutic target genes responsible plc/prf/5 rtâpcr hccs compared culture caused wntâsignaling critically involved affordable assay early detection synthetic conjugates gpr120 agonist insulin resistance reducing hepatorenal email inbox rights reserved data mining issue frequently observed content gpr49 remains
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