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Title[redir]:
Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements - PMC
Description:
Epigenetic modifications such as DNA methylation play a key role in gene regulation and disease susceptibility. However, little is known about the genome-wide frequency, localization, and function of methylation variation and how it is regulated by ...
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methylation, doi, dna, sites, expression, metqtl, gene, google, scholar, pubmed, pmc, tissue, article, adipose, free, data, analysis, variation, human, figure, regions, significant, cpg, disease, genetic, site, genes, probes, fdr, association, table, found, levels, associations, effect, variants, sequence, common, mapping, loci, promoter, overlapping, genome, genet, eqtl, hkme, enhancer, samples, array, model,
Topics {✒️}
allele-specific dna methylation adipose-tissue-specific metqtl identified web resources high-density lipoprotein cholesterol cell type-dependent manner bs-treated dna input covaris e220 focused-ultrasonicator tissue-based methylome survey peripheral-blood-derived dna genome-wide association loci arrayexpress accession numbers tissue-specific gene regulation chip-seq input files pmc beta search pmc copyright notice genome-wide association analysis embryonic stem cells genome-wide association studies genome-wide association study photo-protected area adjacent joint multiple-snp analysis methylation quantitative-trait loci single-base extension step population-based cellular phenotyping identified common complex-trait adipose-tissue-derived dna unique large-scale population unbiased disease-tailored studies hypothesis-free approach calling tissue-dependent effects aligned chip-seq reads bisulphite-treated dna samples insulin-dependent diabetes mellitus insulin-dependent diabetes mellitus single allele resolution [google scholar] 26 estimated narrow-sense heritability linear mixed-effects model family-based association tests blood-derived dna samples adipose-dependent gene regulation linear mixed-effects models expression-probe combinations mapping high-confidence expression metqtl variance-component model adjusting bisulphite-converted reference genome tissue-specific influence metqtl overlapping metabolic-trait multiple primary tissues population-scale sequencing
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