
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Sodium Chloride Drives Autoimmune Disease by the Induction of Pathogenic Th17 Cells - PMC
Description:
There has been a marked increase in the incidence of autoimmune diseases in the last half-century. While the underlying genetic basis of this class of diseases has recently been elucidated implicating predominantly immune response genes1, changes in ...
Matching Content Categories {📚}
- Science
- Education
- Health & Fitness
Content Management System {📝}
What CMS is ncbi.nlm.nih.gov built with?
Custom-built
No common CMS systems were detected on Ncbi.nlm.nih.gov, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of ncbi.nlm.nih.gov audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Ncbi.nlm.nih.gov Make Money? {💸}
We can't figure out the monetization strategy.
While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Ncbi.nlm.nih.gov might have a hidden revenue stream, but it's not something we can detect.
Keywords {🔍}
cells, doi, fig, pubmed, google, scholar, nacl, data, expression, ila, pmc, highsalt, cell, analysed, article, sgk, free, nfat, supplementary, autoimmune, induction, naïve, presence, eae, increased, human, stimulated, induced, anticd, mice, analysis, conditions, pmapk, salt, facs, biosciences, nature, shown, effect, qrtpcr, diseases, absence, control, diet, specific, differentiation, additional, performed, ebioscience, pathogenic,
Topics {✒️}
13mg/kg/body-weight polyinosinic-polycydidylic acid mx-cre+/p38αfl/fl mice37 maintained serum-free x-vivo15 medium sodium/myo-inositol cotransporter slc5a3 secondary anti-rabbit-hrp conjugated secondary anti-mouse-hrp conjugated tgf-β1/il-1β/il-6/il-21/il-23 glucocorticoid-inducible protein kinase pro-inflammatory cytokines gm-csf enzyme-linked immunosorbent assay high-salt-induced th17 cells p38/map kinase pathway high-salt diet develop glucocorticoid-regulated kinase-1 antagonist legends nihms500370-supplement-supplementary_figures_and_legends parametric mann-whitney test population-wide sodium reduction myelin oligodendrocyte glycoprotein-specific plate-bound anti-cd3 plate bound anti-cd3 cytokine-induced th17 polarization pmc beta search intracellular staining anti-il-17a live/dead cell kit serum/glucocorticoid-regulated kinase 1 p38α decreased il-17a high-salt induced expression nacl-mediated extracellular hypertonicity true low-salt diet pro-inflammatory cytokines il-2 cell-mediated immune mechanisms high-salt conditions activate high-salt conditions continued cd45ra+cd45ro−cd25−cd127+ cd45ra−cd45ro+cd25−cd127+ high-salt exposed cells high-salt induces enhanced il-17a induction p38/mapk pathway involving p38/mapk pathway influenced recombinant human il-1β p38/mapk dependent signals neutralizing anti-ifn-γ high-speed flow cytometry recombinant human tgf-β1 intracellular il-17a detection p38 mapk-dependent pathway upregulated csf2/gm-csf promote p38/mapk activation increased il-17a expression
Questions {❓}
- Do these data indicate that increased salt intake is the long sought-after environmental factor associated with the epidemic of autoimmune disease?
- What might be the physiologic role for the effect of high-salt on the induction of inflammatory Th17 cells?
Social Networks {👍}(6)
External Links {🔗}(90)
- How much does https://doi.org/10.1038/nature11868 net monthly?
- How much money does http://www.nature.com/reprints generate?
- Monthly income for http://www.nature.com/nature
- Income figures for https://doi.org/10.1038/nature10251
- What's the profit of https://scholar.google.com/scholar_lookup?journal=Nature&title=Genetic%20risk%20and%20a%20primary%20role%20for%20cell-mediated%20immune%20mechanisms%20in%20multiple%20sclerosis&volume=476&publication_year=2011&pages=214-9&pmid=21833088&doi=10.1038/nature10251&?
- What's the profit of https://doi.org/10.1146/annurev.immunol.021908.132710?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Annu%20Rev%20Immunol&title=IL-17%20and%20Th17%20Cells&author=T%20Korn&author=E%20Bettelli&author=M%20Oukka&author=VK%20Kuchroo&volume=27&publication_year=2009&pages=485-517&pmid=19132915&doi=10.1146/annurev.immunol.021908.132710&?
- How profitable is https://doi.org/10.1002/ana.21141?
- https://scholar.google.com/scholar_lookup?journal=Ann%20Neurol&title=Environmental%20risk%20factors%20for%20multiple%20sclerosis.%20Part%20II:%20Noninfectious%20factors&author=A%20Ascherio&author=KL%20Munger&volume=61&publication_year=2007&pages=504-13&pmid=17492755&doi=10.1002/ana.21141&'s total income per month
- Income figures for https://doi.org/10.3945/an.110.1002
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Adv%20Nutr&title=2010.%20Strategies%20to%20Reduce%20Sodium%20Intake%20in%20the%20United%20States.%20Washington,%20DC:%20The%20National%20Academies%20Press&author=S%20McGuire&volume=1&publication_year=2010&pages=49-50&pmid=22043452&doi=10.3945/an.110.1002&?
- Learn how profitable https://doi.org/10.1161/CIR.0b013e31820d0793 is on a monthly basis
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Circulation&title=The%20importance%20of%20population-wide%20sodium%20reduction%20as%20a%20means%20to%20prevent%20cardiovascular%20disease%20and%20stroke:%20a%20call%20to%20action%20from%20the%20American%20Heart%20Association&author=LJ%20Appel&volume=123&publication_year=2011&pages=1138-43&pmid=21233236&doi=10.1161/CIR.0b013e31820d0793&?
- Income figures for https://doi.org/10.1093/ije/dyp139
- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=International%20Journal%20of%20Epidemiology&title=Salt%20intakes%20around%20the%20world:%20implications%20for%20public%20health&author=IJ%20Brown&author=I%20Tzoulaki&author=V%20Candeias&author=P%20Elliott&volume=38&publication_year=2009&pages=791-813&pmid=19351697&doi=10.1093/ije/dyp139&?
- How much money does https://doi.org/10.1038/nm.1960 make?
- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Nat%20Med&title=Macrophages%20regulate%20salt-dependent%20volume%20and%20blood%20pressure%20by%20a%20vascular%20endothelial%20growth%20factor-C-dependent%20buffering%20mechanism&author=A%20Machnik&volume=15&publication_year=2009&pages=545-52&pmid=19412173&doi=10.1038/nm.1960&?
- Income figures for https://doi.org/10.1073/pnas.0903958106
- Monthly income for https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=Blocking%20angiotensin-converting%20enzyme%20induces%20potent%20regulatory%20T%20cells%20and%20modulates%20TH1-%20and%20TH17-mediated%20autoimmunity&author=M%20Platten&volume=106&publication_year=2009&pages=14948-53&pmid=19706421&doi=10.1073/pnas.0903958106&
- What are the total earnings of https://doi.org/10.1073/pnas.0903602106?
- How much does https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=Role%20of%20the%20renin-angiotensin%20system%20in%20autoimmune%20inflammation%20of%20the%20central%20nervous%20system&author=J%20Stegbauer&volume=106&publication_year=2009&pages=14942-7&pmid=19706425&doi=10.1073/pnas.0903602106& earn?
- What's the revenue for https://doi.org/10.1038/nature07021?
- What are the earnings of https://scholar.google.com/scholar_lookup?journal=Nature&title=IL-21%20and%20TGF-beta%20are%20required%20for%20differentiation%20of%20human%20T(H)17%20cells&author=L%20Yang&volume=454&publication_year=2008&pages=350-2&pmid=18469800&doi=10.1038/nature07021&?
- Profit of https://scholar.google.com/scholar_lookup?journal=Circ%20Shock&title=Hypertonic%20saline%20enhances%20cellular%20immune%20function&author=WG%20Junger&author=FC%20Liu&author=WH%20Loomis&author=DB%20Hoyt&volume=42&publication_year=1994&pages=190-6&pmid=8055665&
- https://doi.org/10.1038/nature10957 income
- Revenue of https://scholar.google.com/scholar_lookup?journal=Nature&title=Pathogen-induced%20human%20TH17%20cells%20produce%20IFN-gamma%20or%20IL-10%20and%20are%20regulated%20by%20IL-1beta&author=CE%20Zielinski&volume=484&publication_year=2012&pages=514-8&pmid=22466287&doi=10.1038/nature10957&
- How much revenue does https://doi.org/10.1016/j.coi.2009.03.001 generate?
- How much profit is https://scholar.google.com/scholar_lookup?journal=Curr%20Opin%20Immunol&title=Transcriptional%20regulatory%20networks%20in%20Th17%20cell%20differentiation&author=L%20Zhou&author=DR%20Littman&volume=21&publication_year=2009&pages=146-52&pmid=19328669&doi=10.1016/j.coi.2009.03.001& making per month?
- Get to know what's the income of https://doi.org/10.1038/nature09447
- How much does https://scholar.google.com/scholar_lookup?journal=Nature&title=Generation%20of%20pathogenic%20T(H)17%20cells%20in%20the%20absence%20of%20TGF-beta%20signalling&author=K%20Ghoreschi&volume=467&publication_year=2010&pages=967-71&pmid=20962846&doi=10.1038/nature09447& generate monthly?
- What's the monthly money flow for https://doi.org/10.1038/ni.2027?
- Revenue of https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=RORgammat%20drives%20production%20of%20the%20cytokine%20GM-CSF%20in%20helper%20T%20cells,%20which%20is%20essential%20for%20the%20effector%20phase%20of%20autoimmune%20neuroinflammation&author=L%20Codarri&volume=12&publication_year=2011&pages=560-7&pmid=21516112&doi=10.1038/ni.2027&
- What's the profit of https://doi.org/10.1038/ni.2031?
- What's the income of https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=The%20encephalitogenicity%20of%20T(H)17%20cells%20is%20dependent%20on%20IL-1-%20and%20IL-23-induced%20production%20of%20the%20cytokine%20GM-CSF&author=M%20El-Behi&volume=12&publication_year=2011&pages=568-75&pmid=21516111&doi=10.1038/ni.2031&?
- How much does https://doi.org/10.1038/ni.1716 bring in each month?
- How much income is https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=C-C%20chemokine%20receptor%206-regulated%20entry%20of%20TH-17%20cells%20into%20the%20CNS%20through%20the%20choroid%20plexus%20is%20required%20for%20the%20initiation%20of%20EAE&author=A%20Reboldi&volume=10&publication_year=2009&pages=514-23&pmid=19305396&doi=10.1038/ni.1716& earning monthly?
- Find out how much https://doi.org/10.1016/j.immuni.2010.09.009 earns monthly
- See how much https://scholar.google.com/scholar_lookup?journal=Immunity&title=MicroRNA-155%20promotes%20autoimmune%20inflammation%20by%20enhancing%20inflammatory%20T%20cell%20development&author=RM%20O%E2%80%99Connell&volume=33&publication_year=2010&pages=607-19&pmid=20888269&doi=10.1016/j.immuni.2010.09.009& makes per month
- Income figures for https://doi.org/10.1073/pnas.92.26.12230
- How much profit is https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=Osmotic%20regulation%20of%20cytokine%20synthesis%20in%20vitro&author=L%20Shapiro&author=CA%20Dinarello&volume=92&publication_year=1995&pages=12230-4&pmid=8618875&doi=10.1073/pnas.92.26.12230& making per month?
- What are the total earnings of https://doi.org/10.1073/pnas.0403139101?
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=NFAT5/TonEBP%20mutant%20mice%20define%20osmotic%20stress%20as%20a%20critical%20feature%20of%20the%20lymphoid%20microenvironment&author=WY%20Go&author=X%20Liu&author=MA%20Roti&author=F%20Liu&author=SN%20Ho&volume=101&publication_year=2004&pages=10673-8&pmid=15247420&doi=10.1073/pnas.0403139101&?
- Learn about the earnings of https://doi.org/10.1126/scisignal.2000081
- How much does https://scholar.google.com/scholar_lookup?journal=Sci%20Signal&title=Brx%20mediates%20the%20response%20of%20lymphocytes%20to%20osmotic%20stress%20through%20the%20activation%20of%20NFAT5&author=T%20Kino&volume=2&publication_year=2009&pages=ra5&pmid=19211510&doi=10.1126/scisignal.2000081& pull in?
- What's the monthly income of https://doi.org/10.1172/JCI35314?
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=J%20Clin%20Invest&title=Tonicity-dependent%20induction%20of%20Sgk1%20expression%20has%20a%20potential%20role%20in%20dehydration-induced%20natriuresis%20in%20rodents&author=S%20Chen&volume=119&publication_year=2009&pages=1647-58&pmid=19436108&doi=10.1172/JCI35314& each month?
- Explore the financials of https://doi.org/10.1093/nar/gks038
- How much does https://scholar.google.com/scholar_lookup?journal=Nucleic%20Acids%20Res&title=Transcriptional%20regulation%20of%20gene%20expression%20during%20osmotic%20stress%20responses%20by%20the%20mammalian%20target%20of%20rapamycin&author=MC%20Ortells&publication_year=2012&pmid=22287635&doi=10.1093/nar/gks038& pull in monthly?
- How much money does https://doi.org/10.1189/jlb.0410211 generate?
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=J%20Leukoc%20Biol&title=Hypertonic%20stress%20regulates%20T%20cell%20function%20via%20pannexin-1%20hemichannels%20and%20P2X%20receptors&author=T%20Woehrle&volume=88&publication_year=2010&pages=1181-9&pmid=20884646&doi=10.1189/jlb.0410211& each month?
- Revenue of https://doi.org/10.1073/pnas.94.9.4440
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=Cloning%20and%20characterization%20of%20a%20putative%20human%20serine/threonine%20protein%20kinase%20transcriptionally%20modified%20during%20anisotonic%20and%20isotonic%20alterations%20of%20cell%20volume&author=S%20Waldegger&author=P%20Barth&author=G%20Raber&author=F%20Lang&volume=94&publication_year=1997&pages=4440-5&pmid=9114008&doi=10.1073/pnas.94.9.4440&?
- How much does https://doi.org/10.1074/jbc.M002076200 net monthly?
- How much does https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&title=Hyperosmotic%20stress%20stimulates%20promoter%20activity%20and%20regulates%20cellular%20utilization%20of%20the%20serum-%20and%20glucocorticoid-inducible%20protein%20kinase%20(Sgk)%20by%20a%20p38%20MAPK-dependent%20pathway&author=LM%20Bell&volume=275&publication_year=2000&pages=25262-72&pmid=10842172&doi=10.1074/jbc.M002076200& pull in?
- How much revenue does https://doi.org/10.1016/s0016-5085(99)70011-9 bring in?
- How much does https://scholar.google.com/scholar_lookup?journal=Gastroenterology&title=h-sgk%20serine-threonine%20protein%20kinase%20gene%20as%20transcriptional%20target%20of%20transforming%20growth%20factor%20beta%20in%20human%20intestine&author=S%20Waldegger&volume=116&publication_year=1999&pages=1081-8&pmid=10220500&doi=10.1016/s0016-5085(99)70011-9& gross monthly?
- How much does https://doi.org/10.1128/mcb.13.4.2031 gross monthly?
- What are the earnings of https://scholar.google.com/scholar_lookup?journal=Mol%20Cell%20Biol&title=Characterization%20of%20sgk,%20a%20novel%20member%20of%20the%20serine/threonine%20protein%20kinase%20gene%20family%20which%20is%20transcriptionally%20induced%20by%20glucocorticoids%20and%20serum&author=MK%20Webster&author=L%20Goya&author=Y%20Ge&author=AC%20Maiyar&author=GL%20Firestone&volume=13&publication_year=1993&pages=2031-40&pmid=8455596&doi=10.1128/mcb.13.4.2031&?
- How much profit does https://doi.org/10.1159/000016351 make?
- https://scholar.google.com/scholar_lookup?journal=Cell%20Physiol%20Biochem&title=h-sgk%20serine-threonine%20protein%20kinase%20as%20transcriptional%20target%20of%20p38/MAP%20kinase%20pathway%20in%20HepG2%20human%20hepatoma%20cells&author=S%20Waldegger&author=S%20Gabrysch&author=P%20Barth&author=S%20Fillon&author=F%20Lang&volume=10&publication_year=2000&pages=203-8&pmid=11093030&doi=10.1159/000016351& income
- How profitable is https://doi.org/10.1158/0008-5472.CAN-08-1047?
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Cancer%20Research&title=Development%20of%20a%20Small-Molecule%20Serum-%20and%20Glucocorticoid-Regulated%20Kinase-1%20Antagonist%20and%20Its%20Evaluation%20as%20a%20Prostate%20Cancer%20Therapeutic&author=AB%20Sherk&volume=68&publication_year=2008&pages=7475-7483&pmid=18794135&doi=10.1158/0008-5472.CAN-08-1047&?
- Find out how much https://doi.org/10.1016/j.cell.2006.01.040 earns monthly
- https://scholar.google.com/scholar_lookup?journal=Cell&title=A%20lentiviral%20RNAi%20library%20for%20human%20and%20mouse%20genes%20applied%20to%20an%20arrayed%20viral%20high-content%20screen&author=J%20Moffat&volume=124&publication_year=2006&pages=1283-98&pmid=16564017&doi=10.1016/j.cell.2006.01.040&'s financial summary
- Financial intake of https://doi.org/10.4049/jimmunol.0902443
- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=RNA%20interference%20screen%20in%20primary%20human%20T%20cells%20reveals%20FLT3%20as%20a%20modulator%20of%20IL-10%20levels&author=AL%20Astier&volume=184&publication_year=2010&pages=685-93&pmid=20018615&doi=10.4049/jimmunol.0902443&?
- How much does https://doi.org/10.1038/ng0506-500 generate monthly?
- What's https://scholar.google.com/scholar_lookup?journal=Nat%20Genet&title=GenePattern%202.0&author=M%20Reich&volume=38&publication_year=2006&pages=500-1&pmid=16642009&doi=10.1038/ng0506-500&'s gross income?
- Get to know what's the income of https://doi.org/10.1093/biostatistics/4.2.249
- How much does https://scholar.google.com/scholar_lookup?journal=Biostatistics&title=Exploration,%20normalization,%20and%20summaries%20of%20high%20density%20oligonucleotide%20array%20probe%20level%20data&author=RA%20Irizarry&volume=4&publication_year=2003&pages=249-64&pmid=12925520&doi=10.1093/biostatistics/4.2.249& make?
- What's the financial intake of https://doi.org/10.1371/journal.pone.0003742?
- What's the income of https://scholar.google.com/scholar_lookup?journal=PLoS%20One&title=Potential%20relevance%20of%20alpha(1)-adrenergic%20receptor%20autoantibodies%20in%20refractory%20hypertension&author=K%20Wenzel&volume=3&publication_year=2008&pages=e3742&pmid=19011682&doi=10.1371/journal.pone.0003742&?
- https://doi.org/10.1182/blood-2011-02-336552 income
- Monthly income for https://scholar.google.com/scholar_lookup?journal=Blood&title=Activation%20of%20p38%20MAPK%20in%20CD4%20T%20cells%20controls%20IL-17%20production%20and%20autoimmune%20encephalomyelitis&author=R%20Noubade&volume=118&publication_year=2011&pages=3290-300&pmid=21791428&doi=10.1182/blood-2011-02-336552&
- How much does https://doi.org/10.1101/gad.1306705 pull in monthly?
- Revenue of https://scholar.google.com/scholar_lookup?journal=Genes%20Dev&title=p38%20MAP%20kinase%20inhibition%20enables%20proliferation%20of%20adult%20mammalian%20cardiomyocytes&author=FB%20Engel&volume=19&publication_year=2005&pages=1175-87&pmid=15870258&doi=10.1101/gad.1306705&
- Monthly income for https://doi.org/10.1084/jem.20021603
- How much does https://scholar.google.com/scholar_lookup?journal=J%20Exp%20Med&title=Myelin%20oligodendrocyte%20glycoprotein-specific%20T%20cell%20receptor%20transgenic%20mice%20develop%20spontaneous%20autoimmune%20optic%20neuritis&author=E%20Bettelli&volume=197&publication_year=2003&pages=1073-81&pmid=12732654&doi=10.1084/jem.20021603& pull in monthly?
- What's the financial outcome of https://github.com/ncbi?
- What is the earnings of https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323?
- What are the earnings of https://www.nlm.nih.gov/web_policies.html?
- How much profit is https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office making per month?
- How much income is https://www.hhs.gov/vulnerability-disclosure-policy/index.html earning monthly?
- What's the income of https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Amanuscript?
- How much income is https://www.nlm.nih.gov/accessibility.html earning monthly?
- Explore the financials of https://www.nlm.nih.gov/careers/careers.html
- Learn about the earnings of https://www.nlm.nih.gov/
- What's the income generated by https://www.nih.gov/ each month?
- How much does https://www.hhs.gov/ pull in?
- How much income is https://www.usa.gov/ earning monthly?
Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- Foundation
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi