
NCBI . NLM . NIH . GOV {
}
Title[redir]:
A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-derived Human Breast Cancer Xenograft (PDX) Models - PMC
Description:
Breast cancer research is hampered by difficulties in obtaining and studying primary human breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology accurately. To overcome these limitations, we propagated a ...
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Keywords {🔍}
doi, bcm, cancer, xenograft, xenografts, breast, patient, human, tumor, pubmed, google, scholar, mice, lines, res, table, patients, stable, expression, primary, pmc, growth, line, article, clinical, supplemental, transplantation, pbr, tumors, free, cells, samples, transplant, cell, basal, rate, condition, models, idc, treatment, doc, mammary, gene, analysis, figure, post, established, origin, shown, data,
Topics {✒️}
mammary-gland-free fat-pads nod/scid/il2γ-receptor null her2-positive breast cancers--role epithelium-free fat pad endocrine-dependent breast carcinomas bone marrow-derived monocytes progest-erone receptor status akt-independent signaling downstream pmc beta search ice-cold lysis buffer gene expression-based predictors patient-derived breast cancer patient-derived tumour xenografts semi-unsupervised hierarchical clustering quality-controlled tissue resource functional tumor-initiating cells estrogen receptor-negative cancers initial pre-treatment fragments inhibit estradiol-enhanced growth claudin-low intrinsic subtype nonconditioned nod/scid mice single treatment-naive tumor patient/xenograft treatment responses nod/scid mice supplemented cb17 scid/beige mice high-grade tumors relative qualitatively identical manner human mammary gland human breast carcinomas breast cancer based er+/her2-xenograft lines er-negative tumor growth including post-translational modifications mammary fat pad stably transplantable xenografts medicine breast center texas grant rp101251 er-pr-her2+ line er-pr-her2+ tumors scid/beige immunocompromised mice cy5 sample/cy3 control breast cancer research human breast cancer mammary gland development cleared fat pad human breast tissues immature myeloid cells post-treatment surgical specimens er+pr+her2− patient er+pr-her2− patient
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