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Title[redir]:
The genetic landscape of high-risk neuroblastoma - PMC
Description:
Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%1. To determine the spectrum of somatic mutation in high-risk ...
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Keywords {🔍}
doi, pubmed, google, scholar, mutations, neuroblastoma, pmc, supplementary, cases, article, sequencing, analysis, free, genes, data, mutation, genome, cancer, somatic, table, gene, variants, nature, reads, alk, germline, dna, tumor, figure, illumina, frequency, number, human, wgs, genomics, rnaseq, nat, exome, low, nihmssupplementxlsx, xlsx, mycn, cohort, candidate, genet, tumors, samples, sequence, complete, copy,
Topics {✒️}
phi29-based multiple-strand displacement characteristic read-orientation conferred skewed read-orientation combinations childhood cancer-related deaths1 multiple lentigines/leopard syndrome pmc beta search pediatric rhabdoid cancer25 ten rna-seq datasets male/female = blue/pink systematic genome-wide annotation org/cancer/cga clinvar microarray-based predictive models sequence alignment/map format org/labs/wood/dna_repair_genes blood-derived dna samples tumor fraction read-depth gene-centric approach identifies rac/rho pathway regional single-copy gain genome-wide association studies exon-level quantification analysis high-risk neuroblastomas harbor paired-end short reads early-onset parkinson disease clinically-reported variants recorded high-risk neuroblastoma trevor bc cancer agency apparently hyper-mutated tumors rna-seq data sets matched rna-seq data de novo assembly provided disease-specific expertise alexa platform website88 core probe sets immuno-therapeutic strategies protein tyrosine phosphatase copy number analysis copy number calls copy number alterations rna baits similar supplementary materials included copy number variation high-level gains /drupal/ international agency massively parallel sequencing full mutation list arms frequently lost complete genomics genomes low-level gains integrative genomics viewer82
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