
NCBI . NLM . NIH . GOV {
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Title[redir]:
DISTINCT FUNCTIONS OF JNK AND C-JUN IN OXIDANT-INDUCED HEPATOCYTE DEATH - PMC
Description:
Overactivation of c-Jun N-terminal kinase (JNK)/c-Jun signaling is a central mechanism of hepatocyte injury and death including that from oxidative stress. However, the functions of JNK and c-Jun are still unclear, and this pathway also inhibits ...
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Keywords {🔍}
jnk, death, menadione, cells, doi, cjun, cell, hepatocytes, fig, pubmed, google, scholar, inhibition, atp, injury, hepatocyte, tam, levels, liver, activation, rala, pmc, czaja, effect, βoxidation, apoptosis, signaling, stress, treated, kinase, findings, primary, article, total, protein, free, necrosis, treatment, compared, function, sensitized, wang, menadioneinduced, oxidant, effects, resistance, assay, phosphorylation, blocked, mitochondrial,
Topics {✒️}
amino-terminal anti-c-jun antibody carboxy-terminal anti-c-jun antibody c-jun-n-terminal kinase inhibition c-jun nh2-terminal kinase c-jun kinase/stress-activated pathway c-jun n-terminal kinase c-jun n-terminal kinase-1 manipulating jnk/c-jun signaling c-jun [reuther-madrid jun n-terminal kinase 10 μm q-val-asp-oph jnk-dependent c-jun activation jnk/c-jun signaling pathway n-terminal c-jun c-jun-independent cytoprotective effect sustained jnk/c-jun activation c-myc requires zinc block β-oxidation [abdel-aleem jnk/c-jun-mediated death caspase inhibitor q-vd-oph wild-type c-jun amp kinase-mediated activation inducing c-flipl turnover mitogen-activated protein kinase β-galactosidase gene [bradham pmc beta search protein kinase c-mediated truncated c-jun tam67 calcium phosphate-mediated transfection increased c-jun phosphorylation h1 promoter-shrna cassette packaging vectors pmdlg/prre jnk/c-jun signaling jnk/c-jun overactivation c-jun inhibition renders c-jun promoting death nf-κb inactivation converts unphosphorylated c-jun function c-jun fusion protein c-jun-dependent death menadione-treated wild-type cells jnk/sapk signaling pathway tumor necrosis factor β-oxidation mediates resistance total c-jun levels fatty acid β-oxidation anaplastic large-cell lymphomas wild-type rala hepatocytes fibroblasts [reuther-madrid oxidant-induced jnk activation
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