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Title[redir]:
Hepatology
Description:
al kinase (JNK) signaling pathway was examined in the rat hepatocyte cell line RALA255-10G. Adenovirus-mediated NF-κB inactivation led to a prolonged activation of JNK and increased activating protein-1 (AP-1) transcriptional activity in response to TNF treatment. Inhibition of the function of the JNK substrate and AP-1 subunit c-Jun blocked cell death from NF-κB inactivation and TNF as determined by measures of cell survival, numbers of apoptotic and necrotic cells, and DNA hypoploidy. Inhibition of c-Jun function blocked mitochondrial cytochrome c release and activation of caspase-3 and -7. NF-κB therefore blocks the TNF death pathway through down-regulation of JNK and c-Jun/AP-1. In conclusion, sustained JNK activation that occurs in the absence of NF-κB initiates apoptosis through a c-Jun-dependent induction of the mitochondrial death pathway. E-mail:[email protected] *Address reprint requests to: Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461. fax: 718-430-8975. Received November 27, 2001; accepted January 09, 2002; previously published online December 30, 2003 Copyright © 2002 American Association for the Study of Liver Diseases....
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Keywords {🔍}
nfκb, jnk, aasld, activation, liver, log, journal, cjun, tnf, access, hepatology, subscribe, issue, alerts, abstract, inhibition, apoptosis, factor, inactivation, pathway, cell, death, register, member, logo, articles, browse, submit, tnfinduced, sustained, buy, hepatocyte, function, blocked, mitochondrial, copyright, american, association, study, diseases, text, subscribers, members, request, content, service, usa, privacy, policy, publications,
Topics {✒️}
c-jun-dependent induction nf-κb initiates apoptosis aasld members log c-jun/ap-1 c-jun liu mitochondrial death pathway open access policy nf-κb inactivation liver diseases individual subscribers log nf-κb protects institutional users access increased activating protein-1 tnf death pathway artificial intelligence training full text access tnf-induced apoptosis nf-κb cell survival journal tables register subscribe service request 800-638-3030 sustained jnk activation induced apoptosis journal signaling pathway website subscribe sustained activation tnf toxicity transcriptional activity tnf treatment necrotic cells dna hypoploidy email inbox rights reserved data mining prolonged activation ap-1 issue function jnk substrate content dependent inhibition tnf subscribers text activation jnk login
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