
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Inhibition of stromal CXCR4 impairs development of lung metastases - PMC
Description:
Compelling evidence has emerged in recent years indicating that stromal cells play a critical role in disease progression. CXCR4 is a G-protein-coupled receptor with a major role in lymphocyte homing. Its ligand, CXCL12, is a highly efficient ...
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Keywords {🔍}
cxcr, doi, cells, mice, pubmed, google, scholar, cancer, lung, cxcl, cell, tumor, metastases, myeloid, stromal, metastasis, reduced, pmc, expression, role, chemokine, fig, development, plerixafor, article, receptor, cbl, reduction, plerixafortreated, microenvironment, melanoma, tissue, mapk, lungs, free, progression, growth, murine, rev, nlm, evidence, bmdcs, tissues, usa, migration, human, compared, expressed, neoplastic, tumors,
Topics {✒️}
ly6g-positive myeloid/granulocytic cells rat anti-mouse ly-6g stromal-derived factor-1α bone marrow–derived cells vegfr1-activity-independent metastasis formation complete tablets edta-free ly6g-positive myeloid cells g-protein-coupled receptor phospho-p38 mapk decreased myeloid-derived cells reduced cxc chemokine pbsf/sdf-1 specific pathogen-free conditions anti phospho-p38 mapk axis cxcr4–cxcl12 plays cxcr4–cxcl12 axis plays ccrf-cem cell lines phospho-p38 mapkinase level monocyte/macrophage lineage cells pmc beta search 20 mm a-glycerol-phosphate tumor-initiating cell phenotype quantitative rt-pcr analysis 200 μl phosphate-buffered saline real-time pcr analyses tumor-promoting cell type murine b16 cells gene-specific mouse primers b16 melanoma cells methods cell culture cell signaling technology pro-tumor stromal microenvironment elevated sdf-1/cxcl12 secretion phopho-p38 mapk bone marrow origin evaluating cxcr4-inhibiting agents reduced cxcl12/cxcr4 results positive myeloid bmdcs mesenchymal stromal cells anti p38 mapk potent cxcr4 antagonist myeloid differentiation antigen chemokine sdf-1/cxcl12 binds phospho-p38 decrease p38 mapk activity total neoplastic area bone-marrow myelopoiesis plerixafor-treated cxcr4+/+ mice cxcr4+/− plerixafor-treated mice b16 cells pretreated cxcl12 protein expression
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Analytics and Tracking {📊}
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