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Title[redir]:
New Lives Given by Cell Death: Macrophage Differentiation Following Their Encounter with Apoptotic Leukocytes during the Resolution of Inflammation - PMC
Description:
Monocytes that migrate into tissues during inflammatory episodes and differentiate to macrophages were previously classified as classically (M1) or alternatively (M2) activated macrophages, based on their exposure to different fate-determining ...
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Keywords {🔍}
macrophages, pubmed, google, scholar, doi, apoptotic, cells, macrophage, pmc, article, free, serhan, inflammation, tissue, resolution, efferocytosis, expression, phenotype, immunol, promote, mediators, activation, cell, human, production, inflammatory, found, antiinflammatory, lipoxin, activated, arginase, proresolving, fibrosis, signaling, ariel, clearance, lipid, cdblow, cytokines, resolving, repair, express, levels, blood, polarization, schifzuck, monocytes, molecular, mlike, role,
Topics {✒️}
peroxisome proliferator-activated receptor-gamma pmc beta search transforming growth factor-beta aspirin-triggered lipoxin a4 suppress pro-inflammatory eicosanoid myeloid-derived suppressor cells pro-resolving lipid mediators aspirin-triggered epi-lipoxins macrophage pro-inflammatory properties concomitantly reprogramming/immune-silencing 11-cis-13-trans-eicosatetraenoic acid 12/15-lo-derived lipid mediators coordinately induce anti-inflammatory adipocyte-derived th2 cytokines distinct pro-resolving macrophages specific lipid mediators promoting anti-inflammatory properties bleomycin-induced pulmonary fibrosis tissue repair/remodeling short resolution-phase macrophages possess pro-resolving cd11blow macrophages suggests rm/cd11bhigh macrophages fichtner-feigl publisher site pdf tgf-beta1 production limit tissue repair/fibrosis phagocyte ucp2 protein termed resolution-phase macrophages aspirin-triggered lipoxin pro-fibrotic enzyme arginase-1 low-grade m1 activity anti-inflammatory gene expression distinct macrophage subtypes termed resolution-promoting macrophages freire-de-lima monocyte-derived macrophages murine resolution-phase macrophages transcription factor stat6 lipoxin stable analogues vascular inflammation governed pro-inflammatory mediators additional pro-inflammatory specialized lipid mediators docosatriene protectin d1 phosphatidylserine-dependent ingestion mediates key events pmc disclaimer lipid raft clustering macrophage inflammatory signaling display reduced phagocytosis
Questions {❓}
- Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?
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