
NCBI . NLM . NIH . GOV {
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Title[redir]:
The Transcription Factors Snail and Slug Activate the Transforming Growth Factor-Beta Signaling Pathway in Breast Cancer - PMC
Description:
The transcriptional repressors Snail and Slug are situated at the core of several signaling pathways proposed to mediate epithelial to mesenchymal transition or EMT, which has been implicated in tumor metastasis. EMT involves an alteration from an ...
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Keywords {🔍}
snail, slug, doi, expression, cells, cell, tgfbeta, genes, figure, cancer, breast, mcf, google, scholar, pubmed, data, day, pathway, analysis, gene, signaling, pmc, emt, tgfbr, growth, article, control, file, free, migration, epithelial, performed, adenovirus, claudinlow, pvalue, tif, biol, rna, change, markers, rtpcr, gsea, mdamb, additional, phenotype, microarray, luminal, click, tumor, increased,
Topics {✒️}
tgf-beta1-induced epithelial-mesenchymal transition gsa contract gs-00f-003l transforming growth factor-beta zinc-finger transcription factors e-cadherin transcriptional regulators repressing e-cadherin expression tgf-beta inhibitor reduces pmc beta search e-cadherin gene expression cell-fate mapping strategies tgfbeta-par6 polarity pathway tgf-beta signaling diminishes tgf-beta signaling diminished dmem/f-12 medium supplemented tgf-beta induced transdifferentiation �tgf-beta cassette’ group tgf-beta family markers tgf-beta signaling pathway tgf-beta signaling decreased elicit epithelial-mesenchymal transition nucleopore track-etch membranes tgf-beta pathway markers robust multi-array average tgf-beta pathway members increased tgf-beta expression epithelial-mesenchymal transition induced advanced-stage breast cancer multi-step process postulated decreased cell-cell adhesion genes including e-cadherin claudin-low subtype induced tgf-beta signaling inhibitors gov/geo/query/acc immune-mediated eradication claudin-low intrinsic subtype selective small-molecule inhibitors tgf-beta pathway genes supplementary materials included actin-binding protein sensitive real-time pcr validation epithelial cell lines regulate snail1 expression tgf-beta dependent activation nes = normalized enrichment score real-time pcr analysis shows statistically significant tgf-beta inhibitors ly364947 real-time rt-pcr license information pmcid rt-pcr primer sets
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