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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. Social Networks
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We began analyzing https://www.nature.com/articles/1209997, but it redirected us to https://www.nature.com/articles/1209997. The analysis below is for the second page.

Title[redir]:
Snail silencing effectively suppresses tumour growth and invasiveness | Oncogene
Description:
The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial–mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour progression. In this report, we provide evidence for this hypothesis. We show that silencing of Snail by stable RNA interference in MDCK-Snail cells induces a complete mesenchymal to epithelial transition (MET), associated to the upregulation of E-cadherin, downregulation of mesenchymal markers and inhibition of invasion. More importantly, stable interference of endogenous Snail in two independent carcinoma cell lines leads to a dramatic reduction of in vivo tumour growth, accompanied by increased tumour differentiation and a significant decrease in the expression of MMP-9 and angiogenic markers and invasiveness. These results indicate that use of RNA interference can be an effective tool for blocking Snail function, opening the way for its application in new antiinvasive therapies.

Matching Content Categories {📚}

  • Education
  • Telecommunications
  • Social Networks

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 8,426,036 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Doi.org could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

article, pubmed, google, scholar, cas, cell, snail, nature, tumour, ecadherin, expression, biol, cancer, transcription, access, cano, invasion, oncogene, peinado, role, pdf, supplementary, content, factor, progression, cells, epithelial, transition, gene, sci, cookies, information, carcinoma, nieto, figure, privacy, olmeda, epithelialmesenchymal, transitions, open, metastasis, central, data, growth, invasiveness, downregulation, emt, induces, mesenchymal, nat,

Topics {✒️}

nature portfolio permissions reprints privacy policy advertising cell-adhesion molecule e-cadherin nature 392 nature zinc-finger transcription factors small double-stranded rnas social media mdck-snail cells induces pb01 suppresses radio-resistance k-atpase beta1-subunit repressing e-cadherin expression regulating atr signaling e-cadherin gene expression springerlink instant access personal data invasive phenotype linked author correspondence epithelial tumour cells data protection permissions egf-induced emt transcription factor snail snail transcription factor cancer gene therapy cell death vivo tumour growth metalloproteinase rt–pcr transcriptional repressor snail e-cadherin expression perez-moreno ma transcription factors slug vitro cell technologies transcription factors snail privacy tumour cell interactions block tumour progression e-cadherin downregulation cancer cell 8 supplementary figure s2 supplementary figure s3 supplementary figure s4 supplementary figure s5 supplementary figure s6 issue learn epithelial–mesenchymal transitions tumour cells breast carcinomas

Schema {🗺️}

WebPage:
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         headline:Snail silencing effectively suppresses tumour growth and invasiveness
         description:The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial–mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour progression. In this report, we provide evidence for this hypothesis. We show that silencing of Snail by stable RNA interference in MDCK-Snail cells induces a complete mesenchymal to epithelial transition (MET), associated to the upregulation of E-cadherin, downregulation of mesenchymal markers and inhibition of invasion. More importantly, stable interference of endogenous Snail in two independent carcinoma cell lines leads to a dramatic reduction of in vivo tumour growth, accompanied by increased tumour differentiation and a significant decrease in the expression of MMP-9 and angiogenic markers and invasiveness. These results indicate that use of RNA interference can be an effective tool for blocking Snail function, opening the way for its application in new antiinvasive therapies.
         datePublished:2006-10-09T00:00:00Z
         dateModified:2006-10-09T00:00:00Z
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            Apoptosis
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      headline:Snail silencing effectively suppresses tumour growth and invasiveness
      description:The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial–mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour progression. In this report, we provide evidence for this hypothesis. We show that silencing of Snail by stable RNA interference in MDCK-Snail cells induces a complete mesenchymal to epithelial transition (MET), associated to the upregulation of E-cadherin, downregulation of mesenchymal markers and inhibition of invasion. More importantly, stable interference of endogenous Snail in two independent carcinoma cell lines leads to a dramatic reduction of in vivo tumour growth, accompanied by increased tumour differentiation and a significant decrease in the expression of MMP-9 and angiogenic markers and invasiveness. These results indicate that use of RNA interference can be an effective tool for blocking Snail function, opening the way for its application in new antiinvasive therapies.
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      dateModified:2006-10-09T00:00:00Z
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         Cell Biology
         Human Genetics
         Oncology
         Apoptosis
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Social Networks {👍}(1)

External Links {🔗}(238)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

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