
NCBI . NLM . NIH . GOV {
}
Title[redir]:
GSI-I (Z-LLNle-CHO) inhibits Ξ³-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia - PMC
Description:
Gamma secretase inhibitors (GSIs) comprise a growing class of compounds that interfere with the membrane-bound Notch signaling protein and its downstream intra-nuclear transcriptional targets. As GSI-I (Z-LLNle-CHO) is also a derivative of a widely ...
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Keywords {π}
notch, doi, gsii, cells, cell, precursorb, expression, treatment, pubmed, google, scholar, data, figure, blood, supplementary, genes, patients, usa, leukemia, lines, death, signaling, additional, pmc, bcell, gene, patient, free, table, samples, results, article, blasts, apoptosis, mice, click, file, proteosome, activity, group, inhibitor, target, levels, caspase, targets, pathways, show, protein, response, important,
Topics {βοΈ}
notch-mediated anti-apoptotic pathways preβpro b-cell state present/marginal/absent calls obtained gsi-i-mediated cell death gsi-i-dependent cell death dr kevin o'hair leukemic b-cell precursors pmc beta search standard iacuc-approved techniques z-llnle-cho blocks anti-cd19 magnetic beads goat anti-rabbit immunoglobulin foxo3 serine/threonine phosphorylation atf4-atf3-chop cascade early b-cell malignancies immunoglobulin-Ξ² subunit common onestep rt-pcr kits b-cell commitment factor cryo-preserved bone marrow phosphate-buffered saline-vehicle retinoid-inducible nuclear factor early b-cell development rabbit anti-cd10 antibodies 11 pre-b-cell line tanoue b-cell line gamma-secretase inhibitors suppress nod/scid xenograft model mature b-cell neoplasms bortezomib-induced cell death specific pathogen free notch pathway-related genes pre-b-cell lines t-cell lineage commitment rt-pcr analysis showed gsi-induced gut toxicity nod/scid mice engrafted aaalac accredited facility annexin v-pe gsi-treatment induced smaller Ξ³-secretase-selective inhibitors gsi-i-treated 697 cells gsi-i-treated cells induced cell death cell death induced murine xenograft model full-length caspase 3 gene probe set acute lymphoblastic leukemia nat cell biol publisher site pdf
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- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Nature&title=Cis-interactions%20between%20Notch%20and%20Delta%20generate%20mutually%20exclusive%20signalling%20states&author=D%20Sprinzak&author=A%20Lakhanpal&author=L%20Lebon&author=LA%20Santat&author=ME%20Fontes&volume=465&publication_year=2010&pages=86-90&pmid=20418862&doi=10.1038/nature08959&
- How much profit does https://doi.org/10.1182/blood-2008-08-174797 generate?
- https://scholar.google.com/scholar_lookup?journal=Blood&title=Caspase-8%20dependent%20histone%20acetylation%20by%20a%20novel%20proteasome%20inhibitor,%20NPI-0052:%20a%20mechanism%20for%20synergy%20in%20leukemia%20cells&author=CP%20Miller&author=S%20Rudra&author=MJ%20Keating&author=WG%20Wierda&author=M%20Palladino&volume=113&publication_year=2009&pages=4289-4299&pmid=19182209&doi=10.1182/blood-2008-08-174797&'s financial summary
- What's the profit of https://doi.org/10.1046/j.1471-4159.1997.69052075.x?
- How much money does https://scholar.google.com/scholar_lookup?journal=J%20Neurochem&title=Cooperative%20interception%20of%20neuronal%20apoptosis%20by%20BCL-2%20and%20BAG-1%20expression:%20prevention%20of%20caspase%20activation%20and%20reduced%20production%20of%20reactive%20oxygen%20species&author=JB%20Schulz&author=D%20Bremen&author=JC%20Reed&author=J%20Lommatzsch&author=S%20Takayama&volume=69&publication_year=1997&pages=2075-2086&pmid=9349553&doi=10.1046/j.1471-4159.1997.69052075.x& make?
- What's the income of https://doi.org/10.1073/pnas.0910060107?
- https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20USA&title=Notch-activated%20signaling%20cascade%20interacts%20with%20mitochondrial%20remodeling%20proteins%20to%20regulate%20cell%20survival&author=LR%20Perumalsamy&author=M%20Nagala&author=A%20Sarin&volume=107&publication_year=2010&pages=6882-6887&pmid=20339081&doi=10.1073/pnas.0910060107&'s total income per month
- What's https://doi.org/10.1182/blood-2008-02-136762's gross income?
- Profit of https://scholar.google.com/scholar_lookup?journal=Blood&title=Targeting%20the%20Notch1%20and%20mTOR%20pathways%20in%20a%20mouse%20T-ALL%20model&author=K%20Cullion&author=KM%20Draheim&author=N%20Hermance&author=J%20Tammam&author=VM%20Sharma&volume=113&publication_year=2009&pages=6172-6181&pmid=19246562&doi=10.1182/blood-2008-02-136762&
- What's the monthly money flow for https://github.com/ncbi?
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- Check the income stats for https://www.nlm.nih.gov/web_policies.html
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- https://www.hhs.gov/vulnerability-disclosure-policy/index.html's total income per month
- See how much https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal makes per month
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- https://www.nih.gov/'s financial summary
- Earnings of https://www.hhs.gov/
- Discover the revenue of https://www.usa.gov/
Analytics and Tracking {π}
- Google Analytics
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Libraries {π}
- jQuery
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Emails and Hosting {βοΈ}
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