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notch, cells, gsii, cell, precursorb, article, expression, treatment, google, scholar, cas, figure, usa, leukemia, genes, patients, lines, death, signaling, data, bcell, gene, patient, blood, samples, apoptosis, results, supplementary, acute, proteosome, activity, mice, table, nature, blasts, pathways, group, target, levels, caspase, targets, inhibitor, cancer, show, protein, response, important, analysis, lymphoblastic, normal,

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nature portfolio animal research studies onestep rt-pcr kits united blood services nature 2010 nature privacy policy advertising notch-mediated anti-apoptotic pathways pre–pro b-cell state social media present/marginal/absent calls obtained 0/ reprints gsi-i-mediated cell death early b-cell development leukemic b-cell precursors gsi-i-dependent cell death gamma-secretase inhibitors suppress anti-cd19 magnetic beads goat anti-rabbit immunoglobulin standard iacuc-approved techniques z-llnle-cho blocks foxo3 serine/threonine phosphorylation atf4-atf3-chop cascade acute lymphoblastic leukemia nod/scid xenograft model early b-cell malignancies rabbit anti-cd10 antibodies immunoglobulin-β subunit common b-cell commitment factor cryo-preserved bone marrow phosphate-buffered saline-vehicle retinoid-inducible nuclear factor tanoue b-cell line 11 pre-b-cell line mature b-cell neoplasms b-cell development bortezomib-induced cell death notch pathway-related genes author correspondence gamma secretase inhibitor gamma-secretase inhibitor γ-secretase-selective inhibitors pre-b-cell lines t-cell lineage commitment gamma-secretase inhibitors murine xenograft model rt-pcr analysis showed gsi-induced gut toxicity permissions

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      headline:GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia
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