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We began analyzing https://link.springer.com/article/10.1007/s00262-008-0570-x, but it redirected us to https://link.springer.com/article/10.1007/s00262-008-0570-x. The analysis below is for the second page.

Title[redir]:
Possible involvement of regulatory T cells in tumor onset and progression in primary breast cancer | Cancer Immunology, Immunotherapy
Description:
Background The FOXP3 mRNA expression and the other regulatory T cell-related molecules were investigated and compared with clinicopathological parameters in human primary breast cancer. Method This study included 136 breast cancer patients operated in our department from 2003 to 2006. Total RNA was extracted from frozen normal breast and breast cancer tissues, and the expression of FOXP3, IL-10, TGFβ1 and CCL22 mRNA was evaluated using quantitative real-time RT-PCR. Result FOXP3, IL-10, TGFβ1 and CCL22 mRNA expressions were significantly higher in cancer tissue than in normal tissue, not only at pT1, 2, and 3 stages but also at the DCIS stage. There were positive correlations between FOXP3 and IL-10, FOXP3 and TGFβ1, as well as FOXP3 and CCL22 mRNA expressions, respectively. FOXP3 and IL-10 mRNA expressions were significantly upregulated in PgR-negative or HER2-positive tumors. Conclusion These results suggest that regulatory T cells are involved in tumor onset and progression in human primary breast cancer, possibly contributing to poor prognosis of patients with breast cancer.

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cancer, cells, breast, foxp, treg, article, tumor, expression, google, scholar, pubmed, mrna, patients, cas, regulatory, tgfβ, cell, tissue, ccl, expressions, status, progression, yamaguchi, tumors, normal, factor, cdcd, analysis, data, fig, sakaguchi, med, function, involvement, access, study, significantly, dcis, table, shown, immunol, liu, onset, primary, open, human, rna, tissues, quantitative, rtpcr,

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tumor-infiltrating cd4 + t-cell subpopulations quantitative real-time rt-pcr tumor-infiltrating foxp3+cd25+cd4+ regulatory article download pdf transforming growth factor-β vaccine-mediated antitumor immunity scarff–bloom–richardson grades 1 stimulated human cd4+cd25 agonistic anti-gitr mab rnase-free dnase set peripheral cd4+cd25-naïve tgf-beta1 cytokine expression tgf-beta signaling foxp3-expressing treg cells tgf-β signals naturally occurring cd4 cd4+cd25 high privacy choices/manage cookies t-cell receptor early-stage prostate tumors cancer-related imbalance treg cell migration cell-related molecules related subjects mammary gland development treg cell accumulation infiltrating breast carcinoma t-cell responses primary breast cancer anti-gitr antibodies [39] rnase-free water tissue-specific antigens [19] quantitative rt-pcr high-grade tumors anti-cd25 antibody inhibit intestinal inflammation naive cd4+cd25 full access anti-inflammatory mediators contaminating genomic dna foxp3+ tumor-infiltrating transcription factor foxp3 infiltrating ductal carcinoma treg cell development sentinel lymph nodes hormone receptor status cd4+cd25+ regulatory cd4+cd25 + regulatory cd4+cd25+ regulatory breast cancer tissues

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         description:The FOXP3 mRNA expression and the other regulatory T cell-related molecules were investigated and compared with clinicopathological parameters in human primary breast cancer. This study included 136 breast cancer patients operated in our department from 2003 to 2006. Total RNA was extracted from frozen normal breast and breast cancer tissues, and the expression of FOXP3, IL-10, TGFβ1 and CCL22 mRNA was evaluated using quantitative real-time RT-PCR. FOXP3, IL-10, TGFβ1 and CCL22 mRNA expressions were significantly higher in cancer tissue than in normal tissue, not only at pT1, 2, and 3 stages but also at the DCIS stage. There were positive correlations between FOXP3 and IL-10, FOXP3 and TGFβ1, as well as FOXP3 and CCL22 mRNA expressions, respectively. FOXP3 and IL-10 mRNA expressions were significantly upregulated in PgR-negative or HER2-positive tumors. These results suggest that regulatory T cells are involved in tumor onset and progression in human primary breast cancer, possibly contributing to poor prognosis of patients with breast cancer.
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