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Title[redir]:
Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer - PMC
Description:
Adoptive cell transfer (ACT) – based immunotherapies can mediate objective cancer regression in animal models and in up to 70% of patients with metastatic melanoma but it remains unclear whether the tumor vasculature impedes the egress of tumor ...
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Keywords {🔍}
tumor, cells, antibody, mice, doi, act, cell, antivegf, tumors, antitumor, figure, effect, cancer, growth, impact, pubmed, google, scholar, administration, treatment, receiving, infiltration, αvegf, rat, therapy, doses, transfer, antiangiogenic, vegf, agents, melanoma, vasculature, days, igg, pmc, dose, transferred, combination, prior, compared, vascular, endothelial, enhance, patients, survival, article, factor, vegfr, significantly, pmel,
Topics {✒️}
gm-csf-secreting cancer immunotherapy vβ-13-pmel-1 tcr recognizes anti-gp100 transgenic pmel-1 anti-vegf antibody enhances tumor-induced immune suppression mediating anti-vascular effects pmc beta search anti-vegf treatment enhances rat anti-mouse vegfr-2 disrupting vegf/vegfr-2 signaling wilcoxon rank-sum test mouse anti-vegf antibody recombinant vaccinia virus tetramethyl rhodamine isothiocyanate suppress t-cell functions promote leukocyte-endothelium interactions manifesting anti-tumor effects anti-vegf showed significant anti-tumor growth effect adoptively transferred anti-tumor 500μg α-vegf compared adoptively transferred tumor-specific 200μg anti-vegf antibody α-vegf consistently enhanced synergistic anti-tumor effect anti-vegf antibody synergized synergistic anti-tumor effects 200μg α-vegf exhibited groups receiving α-vegf additive anti-tumor effect error bars represent enhanced anti-tumor effects anti-tumor therapeutic effect total body irradiation anti-vegf group compared anti-vegfr-2 antibody administration progression-free survival vitro activated pmel-1-ly5 vegf-specific antibody bevacizumab mice receiving 500μg publisher site pdf proangiogenic factor secreted anti-vascular effect additive anti-tumor impact tumor bearing mice license information pmcid 1μm hgp25-33 peptide labeled bsa molecules full effector function lymphodepleting regimen prior
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