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We began analyzing https://www.jneurosci.org/content/26/5/1604, but it redirected us to https://www.jneurosci.org/content/26/5/1604. The analysis below is for the second page.

Title[redir]:
A Specific Role for NR2A-Containing NMDA Receptors in the Maintenance of Parvalbumin and GAD67 Immunoreactivity in Cultured Interneurons | Journal of Neuroscience
Description:
Several lines of evidence suggest that a hypoglutamatergic condition may induce a phenotypic loss of cortical parvalbumin (PV)-positive GABAergic interneurons, such as that observed in brain tissue of schizophrenic subjects. However, it is not known whether the loss of PV interneurons is a consequence of the hypoglutamatergic condition or a secondary aspect of the disease. We characterized the signaling and subunit expression of NMDA receptors in cultured cortical PV interneurons and determined whether a hypoglutamatergic condition, created by direct application of sublethal concentrations of ketamine or subunit-selective NMDA receptor antagonists, can affect the expression of the GABAergic markers as observed in vivo . Real-time PCR performed on mRNA isolated from single neurons showed that PV interneurons present a fivefold higher NR2A/NR2B ratio than pyramidal neurons. Brief, nontoxic, exposure to NMDA led to an increase in ERK1/2 (extracellular signal-regulated kinase 1/2) and cAMP response element-binding protein phosphorylation in PV interneurons, and this increase was blocked by the NR2A-selective antagonist NVP-AAM077. Application of the nonselective NMDA receptor antagonist ketamine, at sublethal concentrations, induced a time and dose-dependent decrease in parvalbumin and GAD67 immunoreactivity specifically in PV interneurons. These effects were reversible and were also observed with the NR2A-selective antagonist, whereas the NR2B-selective antagonist Ro-25-6981 only partially reduced GAD67 immunoreactivity. Coexposure to the calcium channel opener BayK, or the group I metabotropic glutamate receptor agonist DHPG [( RS )-3,5-dihydroxyphenylglycine] attenuated the decrease in GAD67 and parvalbumin induced by the NMDA receptor antagonists. These results suggest that the activity of NR2A-containing NMDA receptors play a pivotal role in the maintenance of the GABAergic function of PV interneurons.

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Keywords {🔍}

nmda, interneurons, neurons, scholar, receptor, gad, cortical, receptors, openurlcrossrefpubmedgoogle, expression, antagonist, culture, neuronal, immunoreactivity, calcium, nra, parvalbumin, control, ketamine, antagonists, gabaergic, coverslips, fig, mrna, decrease, cultures, pyramidal, population, brain, effects, analyzed, cells, protein, activation, phosphorylation, nrb, immunocytochemistry, fluorescence, schizophrenia, neurosci, full, observed, nvpaam, results, subunits, antibodies, openurlabstractfree, textgoogle, subunit, concentrations,

Topics {✒️}

n-methyl-d-aspartate receptor n-methyl-d-aspartate receptors pyk2/src-family kinase pathway subunit-selective antagonists nvp-aam077 nr2a-selective antagonist nvp-aam077 cortico-limbo-thalamic circuitry mouse glyceraldehyde-3-phosphate dehydrogenase sox1-gfp reporter mouse parvalbumin/capase-3 double-positive cells topo-ta cloning vector calcium-permeable ampa receptors ets domain-binding sites poly-l-lysine overnight 1a/2b receptor composition perceptual attentional set-shifting phorbol ester-induced activation hippocampal long-term potentiation 100 μg/ml penicillin/streptomycin αcamkii/caspase-3 double-positive neurons dose–response multiple comparison openurlpubmedgoogle scholar ↵kato-negishi attentional set-shift task nr2a-selective antagonist decreased methods neuronal-glial cocultures nmda-mediated ca2+ influx nmda antagonist-mediated effect calcium-binding protein parvalbumin alexafluor-conjugated secondary antibodies nmda antagonist-mediated decrease poly-d-lysine nr2b-selective antagonist ro-25-6981 single-cell mrna amplification low-density dissociated cultures long-term transcriptional effects calcium-binding proteins parvalbumin ampa-type glutamate receptors interneuronal postsynaptic-protein citron counting double-immunostained neurons calcium channel opener single-cell reverse transcription calcium signal resulting ca2+-permeable ampa multiple comparison procedures nmda receptor current authors editorial board hepes-controlled salt solution issue journal continuous current injection glutamate receptor dysfunction temperature controller equipped

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