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Title[redir]:
Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand - PMC
Description:
Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate and mobilize to circulation following specific signals. Matrix metalloproteinase-9 (MMP-9), induced in BM cells, releases soluble Kit-ligand ...
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Keywords {🔍}
mmp, cells, mice, cell, stem, hematopoietic, doi, skitl, mobilization, figure, pubmed, google, scholar, progenitor, release, recruitment, hscs, sdf, data, recovery, stromal, day, pmc, treatment, endothelial, vegf, niche, days, levels, article, increased, factor, number, plasma, vascular, differentiation, reconstitution, progenitors, gcsf, blood, treated, rapid, pbmcs, free, quiescent, ckit, hematopoiesis, cytokines, mkitl, ceps,
Topics {✒️}
lin−sca-1+c-kit+ repopulating cells granulocyte colony-stimulating factor lin−sca-1+c-kit+ comprise chemo/cytokine-induced hsc mobilization lin−sca-1+c-kit+ cells g-csf-mobilized pbmcs harvested supp2 nihms157527-supplement-supp2 mobilized sca-1+c-kit+ cells anti-mouse igg-conjugated colony-forming unit cells /cgi/content/full/109/5/625/dc1 chemokine stromal-derived factor-1 chemo/cytokine-induced upregulation bone-marrow-derived endothelial stromal cell-derived factor-1 anti-human vwf/hrp pmc beta search short-term repopulating potential serum-free medium overnight long-term repopulating hscs lin−sca-1+c-kit+ stem cell-active cytokine long-term cultures kit/mkit ligand pathway germ-free conditions c-kit produce defects 137cs γ-ray source releases soluble kit-ligand c-kit negative stem colony forming units supplementary materials included stem/progenitor cell pools chemokine-treated scid mice organ-specific stem cells lineage-specific monoclonal antibodies avoid life-threatening infection ltc-ic assays lin−sca-1+ bm cells cell-surface-bound cytokines bm-derived stem cells c-kit+ stem/progenitors stem cell-active cytokines serum-free medium stem/progenitor cell pool tissue-specific stem cells chemo/cytokine levels bm-derived endothelial progenitors g-csf-mobilized pbmcs stem cell-active chemokines wild-type mice increased
Questions {❓}
- But what regulates MMP-9?
- The evolving concept of a stem cell: entity or function?
- What is the role of increased sKitL levels in the context of hematopoietic recovery after BM suppression or stem cell mobilization?
- Why are HSCs mobilized after stress?
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