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Keywords {🔍}

mutant, disease, sod, doi, pubmed, google, scholar, neurons, motor, pmc, article, cells, free, astrocytes, cell, damage, mice, progression, expression, neurosci, amyotrophic, lateral, sclerosis, prion, onset, mouse, superoxide, familial, neuron, model, spinal, microglia, science, toxicity, synthesis, dismutase, neuronal, fig, glutamate, nat, degeneration, types, protein, cleveland, selective, mutations, multiple, including, gene, expressed,

Topics {✒️}

cu/zn superoxide dismutase nervous system–specific nestin-cre polyglutamine-expanded ataxin-7 promotes pmc beta search dismutase-active mutant sod1 sod1—including dismutase-active pmc copyright notice p0-cre–mediated excision lhx3-driven cre transgene long-term suppression cell injury—triggers unregulated cell death–related proteins sod1 mutant-mediated als mutant sod1-mediated als wild-type sod1—interact sod1-mediated familial als blood–spinal cord barrier prion-mediated wasting disease sod1 mutant-mediated disease mutant sod1-mediated disease mutant sod1 induces mutant-expressing microglial cells microglial-derived inos activity als-linked sod1 mutants cell type–selective excision mutant-driven toxic mechanisms damage-producing pathways converge pathological cell–cell interactions pathological cell-cell interactions cell surface—rac1 binding mutant sod1-dependent toxicity axon-ensheathing schwann cells nearby prpc-negative neurons mutant superoxide dismutase mutant superoxide dismutase-1 blood–brain barrier leads amyotrophic lateral sclerosis publisher site pdf bone marrow transplantation enhance calcium-dependent excitotoxicity scrapie-specific neuronal lesions normal microglia—impairs proliferation mutant gene products mutant sod1-expressing unidentified soluble factor mptp-induced animal models retrogradely transported stress misfolded mutant sod1 glur2-regulating capacity wild-type sod1

Questions {❓}

• First, what are the mutant-driven toxic mechanisms that mediate disease?
• From the confusing diversity of proposed toxic pathways, which is correct?
• How does this help with understanding the basis of selectivity in neuronal loss?
• So which cell types develop damage that contributes to the spread of motor neuron injury?

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• What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20USA.&title=Gene%20transfer%20demonstrates%20that%20muscle%20is%20not%20a%20primary%20target%20for%20non-cell-autonomous%20toxicity%20in%20familial%20amyotrophic%20lateral%20sclerosis&author=T.M.%20Miller&author=S.H.%20Kim&author=K.%20Yamanaka&author=M.%20Hester&author=P.%20Umapathi&volume=103&publication_year=2006&pages=19546-19551&pmid=17164329&doi=10.1073/pnas.0609411103&?
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• Earnings of https://scholar.google.com/scholar_lookup?journal=Acta%20Neuropathol.&title=Expression%20of%20monoamine%20oxidase%20B%20activity%20in%20astrocytes%20of%20senile%20plaques&author=S.%20Nakamura&author=T.%20Kawamata&author=I.%20Akiguchi&author=M.%20Kameyama&author=N.%20Nakamura&volume=80&publication_year=1990&pages=419-425&pmid=2239154&doi=10.1007/BF00307697&
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• How much does https://scholar.google.com/scholar_lookup?journal=Nat.%20Neurosci.&title=Selective%20vulnerability%20and%20pruning%20of%20phasic%20motoneuron%20axons%20in%20motoneuron%20disease%20alleviated%20by%20CNTF&author=S.%20Pun&author=A.F.%20Santos&author=S.%20Saxena&author=L.%20Xu&author=P.%20Caroni&volume=9&publication_year=2006&pages=408-419&pmid=16474388&doi=10.1038/nn1653& make?
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• See how much https://scholar.google.com/scholar_lookup?journal=Ann.%20Neurol.&title=Selective%20loss%20of%20glial%20glutamate%20transporter%20GLT-1%20in%20amyotrophic%20lateral%20sclerosis&author=J.D.%20Rothstein&author=M.%20Van%20Kammen&author=A.I.%20Levey&author=L.J.%20Martin&author=R.W.%20Kuncl&volume=38&publication_year=1995&pages=73-84&pmid=7611729&doi=10.1002/ana.410380114& makes per month
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• How much money does https://doi.org/10.1126/science.1154584 generate?
• What's the income of https://scholar.google.com/scholar_lookup?journal=Science.&title=TDP-43%20mutations%20in%20familial%20and%20sporadic%20amyotrophic%20lateral%20sclerosis&author=J.%20Sreedharan&author=I.P.%20Blair&author=V.B.%20Tripathi&author=X.%20Hu&author=C.%20Vance&volume=319&publication_year=2008&pages=1668-1672&pmid=18309045&doi=10.1126/science.1154584&?
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• How profitable is https://scholar.google.com/scholar_lookup?journal=Nat.%20Rev.%20Neurosci.&title=Pathways%20to%20motor%20incoordination:%20the%20inherited%20ataxias&author=F.%20Taroni&author=S.%20DiDonato&volume=5&publication_year=2004&pages=641-655&pmid=15263894&doi=10.1038/nrn1474&?
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• How much does https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20USA.&title=Cyclooxygenase-2%20is%20instrumental%20in%20Parkinson's%20disease%20neurodegeneration&author=P.%20Teismann&author=K.%20Tieu&author=D.K.%20Choi&author=D.C.%20Wu&author=A.%20Naini&volume=100&publication_year=2003&pages=5473-5478&pmid=12702778&doi=10.1073/pnas.0837397100& make?
• How much profit is https://doi.org/10.1038/mt.2008.73 making per month?
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• What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Prog.%20Neurobiol.&title=Transgenics,%20toxicity%20and%20therapeutics%20in%20rodent%20models%20of%20mutant%20SOD1-mediated%20familial%20ALS&author=B.J.%20Turner&author=K.%20Talbot&volume=85&publication_year=2008&pages=94-134&pmid=18282652&doi=10.1016/j.pneurobio.2008.01.001&?
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• https://doi.org/10.1073/pnas.0712209105's financial summary
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• How much money does https://scholar.google.com/scholar_lookup?journal=Glia.&title=Epigenetic%20regulation%20of%20neuron-dependent%20induction%20of%20astroglial%20synaptic%20protein%20GLT1&author=Y.%20Yang&author=O.%20Gozen&author=S.%20Vidensky&author=M.B.%20Robinson&author=J.D.%20Rothstein&publication_year=2009a&pmid=19672971&doi=10.1002/glia.20922& generate?
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• How much revenue does https://scholar.google.com/scholar_lookup?journal=Neuron.&title=Presynaptic%20regulation%20of%20astroglial%20excitatory%20neurotransmitter%20transporter%20GLT1&author=Y.%20Yang&author=O.%20Gozen&author=A.%20Watkins&author=I.%20Lorenzini&author=A.%20Lepore&volume=61&publication_year=2009b&pages=880-894&pmid=19323997&doi=10.1016/j.neuron.2009.02.010& bring in?
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• What's the revenue for https://scholar.google.com/scholar_lookup?journal=Neuron.&title=Mouse%20model%20of%20multiple%20system%20atrophy%20alpha-synuclein%20expression%20in%20oligodendrocytes%20causes%20glial%20and%20neuronal%20degeneration&author=I.%20Yazawa&author=B.I.%20Giasson&author=R.%20Sasaki&author=B.%20Zhang&author=S.%20Joyce&volume=45&publication_year=2005&pages=847-859&pmid=15797547&doi=10.1016/j.neuron.2005.01.032&?
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• What is the monthly revenue of https://www.hhs.gov/?
• https://www.usa.gov/'s revenue stream

Analytics and Tracking {📊}

• Google Analytics
• Google Analytics 4
• Google Tag Manager

Libraries {📚}

• jQuery
• jQuery module (jquery-3.6.0)
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• nihcesxway.hub.nih.gov
• nihcesxway2.hub.nih.gov
• nihcesxway3.hub.nih.gov
• nihcesxway4.hub.nih.gov
• nihcesxway5.hub.nih.gov

Name Servers:

• dns1-ncbi.ncbi.nlm.nih.gov
• dns2-ncbi.ncbi.nlm.nih.gov
• lhcns1.nlm.nih.gov
• lhcns2.nlm.nih.gov

CDN Services {📦}

• Ncbi