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Title[redir]:
IL-21 and TGF-β are required for differentiation of human TH17 cells - PMC
Description:
The recent discovery of CD4+ T cells characterized by secretion of interleukin (IL)-17 (TH17 cells) and the naturally occurring regulatory FOXP3+ CD4 T cell (nTreg) has had a major impact on our understanding of immune processes not readily ...
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Keywords {🔍}
cells, tgfβ, differentiation, naive, human, doi, secretion, ila, nature, induce, rorc, ilβ, induced, pubmed, google, scholar, ifnγ, cell, mouse, pmc, cytokines, blood, memory, data, combination, shown, expression, fig, induction, nlm, central, transcription, antibodies, staining, obtained, cord, ncbi, search, article, foxp, inflammatory, promote, stimulated, mrna, methods, biosciences, immunol, required, anticd, monoclonal,
Topics {✒️}
serum-free x-vivo15 medium cd4+cd25−cd62l+cd45ra− cells enriched sorted cd4+cd25−cd62l+cd45rahi cells plate-bound anti-cd3 high-speed flow cytometry transforming growth factor-β serum-free medium cd25−cd62l+cd45rahi pmc beta search anti-ifn-γ-pe enzyme-linked immunosorbent assay upregulate ifn-γ secretion cd25−cd62l+cd45ra− induce il-17a secretion cytokine il-1β induced il-21-induced il-17 secretion full methods publisher site pdf cd25–apc–cy7 cd45ra–pe–cy7 real-time pcr tgf-β suppresses th1/th2 paradigm including multiple sclerosis catalogue number 240-b-002 rneasy mini kit unidentified transcription factor cell receptor ligation anti-il-10–pe anti-il-10-pe chemokine receptor ccr7 receptor-activated monocytes american cancer society human inflammatory disease ifn-γ secretion anti-il-17–apc anti-il-17-apc inflammatory bowel disease license information pmcid induces th17 differentiation human th17 cells10 17 cell-mediated pathology induce th17 differentiation il-17a secretion tgf-β suppressed united states government final edited form clare baecher-allan 1 molecular mechanisms involved autocrine amplification loop6-8
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