
NCBI . NLM . NIH . GOV {
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Title[redir]:
Peroxisome proliferator-activated receptor gamma (PPARγ) overexpression suppresses growth and induces apoptosis in human multiple myeloma cells - PMC
Description:
Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a transcription factor that regulates immune and inflammatory responses. Our laboratory has demonstrated that normal and malignant B cells, including multiple myeloma, express PPARγ. ...
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Keywords {🔍}
cells, pparγ, multiple, myeloma, doi, cell, infected, lvempty, lvpparγ, apoptosis, pubmed, google, scholar, overexpression, human, bmscs, figure, ligands, results, expression, peroxisome, ciglitazone, proliferation, aad, production, proliferatoractivated, receptor, death, hours, cancer, gamma, levels, caspase, protein, induces, vector, activation, rpmi, pmc, lvpparγdn, treatment, flow, lentiviral, uninfected, effects, transduced, control, analyzed, membrane, apoptotic,
Topics {✒️}
peroxisome proliferator-activated receptor-gamma pcdna-flag-pparγ1 wild type peroxisome proliferator-activated receptors anti-annexin v-apc mab ppre-luciferase reporter plasmid lymphomas express ppar-gamma flag-tagged pparγ1 cdna flag-pparγ1-dn cdna embryonic kidney cells bortezomib-induced cell death chemotherapy-induced drug resistance ppar-gamma-mediated regulation anti-apoptotic protein belonging lv-pparγ-dn transfected cells pro-apoptotic effects resulting broad-spectrum caspase inhibitor extracellular signal-regulated kinases anti-inflammatory cyclopentenone prostaglandins pax8-ppargamma1 fusion oncogene regulating anti-apoptotic proteins g0/g1 dna content rabbit polyclonal anti-mcl-1 g0/g1 cell population pmc beta search flag-tagged pparγ protein transcription factors nf-κb il-6-independent multiple myeloma mm-induced il-6 production 48hr post-infection lv-empty lv-pparγ dn showed enzyme-linked immunosorbent assay inhibits ppargamma-mediated adipogenesis lv-pparγ-dn resulted ppar-gamma agonists pparγ-ligand induced apoptosis 7-aad single-positive cells lv-pparγ-dn vector anti-apoptotic protein mcl-1 malignant b-lineage cells anti-apoptotic protein xiap hs-5 bmsc-dcoated plates packaging vector pcmv-δ89 high-affinity synthetic ligands characteristic round morphology anti-apoptotic proteins xiap anti-brdu-apc antibody hs-5 bmsc-coated plates pparγ-overexpression induces apoptosis lv-pparγ vector exhibited overexpression suppresses growth
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