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Title[redir]:
Current Opinion in Hematology
Description:
cussed. Recent findings The immunomodulatory drugs, thalidomide and lenalidomide, and the proteasome inhibitor, bortezomib, have been shown to be effective agents, both alone and as part of combination regimens, for the treatment of myeloma. Studies are now focusing on the optimal sequencing of these drugs throughout the disease course, with a view to maximizing antitumor efficacy and minimizing overlapping toxicities. New protocols are increasingly based on preclinical evidence of synergy. The incorporation of these agents into transplant-based treatment protocols has improved outcomes. Other examples of novel agents undergoing assessment at present include arsenic trioxide, hsp90 inhibitors and histone deacetylase inhibitors. Future developments are likely to include individualized treatment plans based on patient-specific parameters including cytogenetic analysis and gene expression profiling. Summary Thalidomide, lenalidomide and bortezomib can now be considered as standard options both as first-line agents and beyond for the treatment of myeloma, with respective combinations also emerging as valid choices for all stages of the disease....
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Keywords {π}
journal, treatment, agents, issue, myeloma, access, subscribe, alerts, authors, abstract, current, log, register, logo, articles, issues, therapies, buy, recent, evidence, undergoing, drugs, thalidomide, lenalidomide, bortezomib, disease, protocols, based, include, inhibitors, choices, text, subscribers, request, browse, content, submit, service, privacy, policy, secondary, advanced, search, info, previous, hematopoietic, stem, cell, transplantation, edited,
Topics {βοΈ}
transplant-based treatment protocols journal authors submit full text access /ii trial evaluation maximizing antitumor efficacy minimizing overlapping toxicities gene expression profiling artificial intelligence training agents undergoing assessment histone deacetylase inhibitors etoc alerts service request 800-638-3030 register subscribe individual subscribers log journal tables valid choices current evidence issue increasingly based website subscribe journal hsp90 inhibitors center submit effective agents line agents recent years trials leading recent findings proteasome inhibitor combination regimens optimal sequencing preclinical evidence improved outcomes future developments standard options respective combinations email inbox rights reserved data mining immunomodulatory drugs summaryΒ thalidomide myeloma hayden authors content protocols treatment agents log subscribers text
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