
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions - PMC
Description:
Over 90% of all cancers are carcinomas, malignancies derived from cells of epithelial origin. As carcinomas progress, these tumors may lose epithelial morphology and acquire mesenchymal characteristics which contribute to metastatic potential. An ...
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Keywords {๐}
doi, pubmed, google, scholar, cancer, cell, cells, growth, egfr, tumor, ecadherin, factor, emt, receptor, signaling, epithelial, expression, metastasis, shown, transition, igfr, erlotinib, pmc, survival, breast, mesenchymal, cellular, article, pathways, carcinoma, inhibition, res, activation, snail, transitions, epidermal, lines, free, biol, human, apoptosis, kinase, inhibitors, insulinlike, invasion, emtlike, progression, phenotype, transcriptional, sensitivity,
Topics {โ๏ธ}
ras-raf-mek-erk pathways igf-1r-irs1-akt axis platelet-derived growth factor igf-1r/pi3k signaling axis epidermal growth factor/hydrocortisone igf-1r/egfr cross-talks e-cadherin-repressing transcription factors pi3 kinase-akt-mtor pi 3-kinase/akt signaling pi3k-akt survival pathway pmc beta search igf-1r tyrosine kinase fibroblast-derived epithelial morphogen small-cell lung cancer ras-mapk proliferative pathway egf receptor/akt pathway regulating pro-apoptotic pathways zinc-finger transcription factors hormone-refractory prostate cancer bypassing egfr-dependent activation tight cellโcell junctions downregulate endogenous e-cadherin affect e-cadherin repressors dominant negative mutant epidermal growth factor tgf-ฮฒ induced apoptosis blivet-van eggelpoel mj tgf-beta confers resistance igf-1r targeted therapeutics e-cadherin converts cells e-cadherin mutant cells e-cadherin gene expression epithelial-mesenchymal transition induced suppress e-cadherin expression high-grade prostate cancer growth factor receptor growth factor-1 receptor small molecule inhibitors survived tgf-ฮฒ treatment repressing e-cadherin expression trastuzumab-refractory breast cancer partial epithelial-mesenchymal transition small cell lung alternate growth factor increased igf-1r signaling igf-1r targeted therapies osi pharmaceuticals/genetech/roche publisher site pdf pi3 kinase pathway transitions igf-1r signaling
Questions {โ}
- Epidermal growth factor receptor dependence in human tumors: more than just expression?
- Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
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- Learn how profitable https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Insulin-like%20growth%20factor%20receptor%20I%20mediates%20resistance%20to%20anti-epidermal%20growth%20factor%20receptor%20therapy%20in%20primary%20human%20glioblastoma%20cells%20through%20continued%20activation%20of%20phosphoinositide%203-kinase%20signaling&author=A%20Chakravarti&author=JS%20Loeffler&author=NJ%20Dyson&volume=62&issue=1&publication_year=2002&pages=200-207&pmid=11782378& is on a monthly basis
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- How much does https://scholar.google.com/scholar_lookup?journal=Endocr%20Relat%20Cancer&title=Insulin-like%20growth%20factor-I%20receptor%20signalling%20and%20acquired%20resistance%20to%20gefitinib%20(ZD1839;%20Iressa)%20in%20human%20breast%20and%20prostate%20cancer%20cells&author=HE%20Jones&author=L%20Goddard&author=JM%20Gee&volume=11&issue=4&publication_year=2004&pages=793-814&pmid=15613453&doi=10.1677/erc.1.00799& gross monthly?
- What's the financial gain of https://doi.org/10.1002/ijc.21512?
- How much profit does https://scholar.google.com/scholar_lookup?journal=Int%20J%20Cancer&title=Targeting%20the%20epidermal%20growth%20factor%20receptor%20by%20erlotinib%20(Tarceva)%20for%20the%20treatment%20of%20esophageal%20cancer&author=AP%20Sutter&author=M%20Hopfner&author=A%20Huether&volume=118&issue=7&publication_year=2006&pages=1814-1822&pmid=16217753&doi=10.1002/ijc.21512& generate?
- What's the income of https://doi.org/10.1016/j.canlet.2006.08.004?
- https://scholar.google.com/scholar_lookup?journal=Cancer%20Lett&title=Insulin-like%20growth%20factor-1%20receptor%20and%20ligand%20targeting%20in%20head%20and%20neck%20squamous%20cell%20carcinoma&author=MG%20Slomiany&author=LA%20Black&author=MM%20Kibbey&volume=248&issue=2&publication_year=2007&pages=269-279&pmid=16996205&doi=10.1016/j.canlet.2006.08.004&'s total income per month
- What are the earnings of https://doi.org/10.1016/s0026-0495(96)90178-x?
- Income figures for https://scholar.google.com/scholar_lookup?journal=Metabolism&title=Severe%20resistance%20to%20insulin%20and%20insulin-like%20growth%20factor-I%20in%20cells%20from%20a%20patient%20with%20leprechaunism%20as%20a%20result%20of%20two%20mutations%20in%20the%20tyrosine%20kinase%20domain%20of%20the%20insulin%20receptor&author=C%20Desbois-Mouthon&author=C%20Danan&author=S%20Amselem&volume=45&issue=12&publication_year=1996&pages=1493-1500&pmid=8969282&doi=10.1016/s0026-0495(96)90178-x&
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- https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Heterodimerization%20of%20insulin-like%20growth%20factor%20receptor/epidermal%20growth%20factor%20receptor%20and%20induction%20of%20survivin%20expression%20counteract%20the%20antitumor%20action%20of%20erlotinib&author=F%20Morgillo&author=JK%20Woo&author=ES%20Kim&volume=66&issue=20&publication_year=2006&pages=10100-10111&pmid=17047074&doi=10.1158/0008-5472.CAN-06-1684&'s total income per month
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=A%20dominant%20negative%20mutant%20of%20the%20insulin-like%20growth%20factor-I%20receptor%20inhibits%20the%20adhesion,%20invasion,%20and%20metastasis%20of%20breast%20cancer&author=SE%20Dunn&author=M%20Ehrlich&author=NJ%20Sharp&volume=58&issue=15&publication_year=1998&pages=3353-3361&pmid=9699666& each month?
- How much does https://doi.org/10.1089/104303401753204544 rake in every month?
- Income figures for https://scholar.google.com/scholar_lookup?journal=Hum%20Gene%20Ther&title=Inhibition%20of%20carcinoma%20cell%20growth%20and%20metastasis%20by%20a%20vesicular%20stomatitis%20virus%20G-pseudotyped%20retrovector%20expressing%20type%20I%20insulin-like%20growth%20factor%20receptor%20antisense&author=AA%20Samani&author=L%20Fallavollita&author=DE%20Jaalouk&volume=12&issue=16&publication_year=2001&pages=1969-1977&pmid=11686938&doi=10.1089/104303401753204544&
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Oncol%20Rep&title=Erlotinib%20prevents%20pulmonary%20metastasis%20in%20curatively%20resected%20breast%20carcinoma%20using%20a%20mouse%20model&author=YJ%20Choi&author=SJ%20Nam&author=MJ%20Son&volume=16&issue=1&publication_year=2006&pages=119-122&pmid=16786133& produce monthly?
- What's the financial intake of https://doi.org/10.1677/erc.1.01100?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Endocr%20Relat%20Cancer&title=Suppression%20of%20EGF-R%20signaling%20reduces%20the%20incidence%20of%20prostate%20cancer%20metastasis%20in%20nude%20mice&author=A%20Angelucci&author=GL%20Gravina&author=N%20Rucci&volume=13&issue=1&publication_year=2006&pages=197-210&pmid=16601288&doi=10.1677/erc.1.01100& bring in?
- Find out how much https://doi.org/10.1016/s0304-3835(03)00464-6 earns monthly
- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Cancer%20Lett&title=Gefitinib%20(%E2%80%98Iressa%E2%80%99),%20an%20epidermal%20growth%20factor%20receptor%20tyrosine%20kinase%20inhibitor,%20mediates%20the%20inhibition%20of%20lymph%20node%20metastasis%20in%20oral%20cancer%20cells&author=S%20Shintani&author=C%20Li&author=M%20Mihara&volume=201&issue=2&publication_year=2003&pages=149-155&pmid=14607328&doi=10.1016/s0304-3835(03)00464-6&?
- What's the financial gain of https://doi.org/10.1073/pnas.78.6.3664?
- https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20USA&title=Specific%20receptors%20for%20platelet-derived%20growth%20factor%20on%20cells%20derived%20from%20connective%20tissue%20and%20glia&author=CH%20Heldin&author=B%20Westermark&author=A%20Wasteson&volume=78&issue=6&publication_year=1981&pages=3664-3668&pmid=6943569&doi=10.1073/pnas.78.6.3664&'s financial summary
- How much revenue does https://doi.org/10.1002/glia.440150307 bring in?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Glia&title=Platelet-derived%20growth%20factor%20in%20human%20glioma&author=B%20Westermark&author=CH%20Heldin&author=M%20Nister&volume=15&issue=3&publication_year=1995&pages=257-263&pmid=8586462&doi=10.1002/glia.440150307& produce monthly?
- What's the income of https://doi.org/10.1101/gad.903001?
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Genes%20Dev&title=PDGF%20autocrine%20stimulation%20dedifferentiates%20cultured%20astrocytes%20and%20induces%20oligodendrogliomas%20and%20oligoastrocytomas%20from%20neural%20progenitors%20and%20astrocytes%20in%20vivo&author=C%20Dai&author=JC%20Celestino&author=Y%20Okada&volume=15&issue=15&publication_year=2001&pages=1913-1925&pmid=11485986&doi=10.1101/gad.903001&
- Income figures for https://doi.org/10.1038/sj.onc.1209232
- How much profit does https://scholar.google.com/scholar_lookup?journal=Oncogene&title=Autocrine%20activation%20of%20PDGFRalpha%20promotes%20the%20progression%20of%20ovarian%20cancer&author=D%20Matei&author=RE%20Emerson&author=YC%20Lai&volume=25&issue=14&publication_year=2006&pages=2060-2069&pmid=16331269&doi=10.1038/sj.onc.1209232& make?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Clin%20Cancer%20Res&title=A%20multi-institutional%20phase%20ii%20study%20of%20SU101,%20a%20platelet-derived%20growth%20factor%20receptor%20inhibitor,%20for%20patients%20with%20hormone-refractory%20prostate%20cancer&author=YJ%20Ko&author=EJ%20Small&author=F%20Kabbinavar&volume=7&issue=4&publication_year=2001&pages=800-805&pmid=11309325&?
- How much income does https://doi.org/10.1186/bcr1304 have?
- How much does https://scholar.google.com/scholar_lookup?journal=Breast%20Cancer%20Res&title=Overexpression%20of%20platelet-derived%20growth%20factor%20receptor%20alpha%20in%20breast%20cancer%20is%20associated%20with%20tumour%20progression&author=I%20Carvalho&author=F%20Milanezi&author=A%20Martins&volume=7&issue=5&publication_year=2005&pages=R788-R795&pmid=16168125&doi=10.1186/bcr1304& earn?
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- What's the financial intake of https://scholar.google.com/scholar_lookup?journal=J%20Clin%20Invest&title=Autocrine%20PDGFR%20signaling%20promotes%20mammary%20cancer%20metastasis&author=M%20Jechlinger&author=A%20Sommer&author=R%20Moriggl&volume=116&issue=6&publication_year=2006&pages=1561-1570&pmid=16741576&doi=10.1172/JCI24652&?
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- What's the income of https://scholar.google.com/scholar_lookup?journal=Nat%20Rev%20Cancer&title=Fibroblasts%20in%20cancer&author=R%20Kalluri&author=M%20Zeisberg&volume=6&issue=5&publication_year=2006&pages=392-401&pmid=16572188&doi=10.1038/nrc1877&?
- https://github.com/ncbi's financial summary
- How much does https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323 pull in?
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- Check the income stats for https://www.usa.gov/
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