
DOI . ORG {
}
Title[redir]:
Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production | PNAS
Description:
T cell receptor ζ (TcRζ)/CD3 ligation initiates a signaling cascade that involves src kinases p56lck and ζ-associated protein 70, leading to the phosphorylation of substrates such as TcRζ, Vav, SH2...
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Keywords {🔍}
fyb, cells, protein, lane, scholar, slp, google, pubmed, cell, crossref, domain, cdna, lanes, fyn, residues, antifyb, data, expression, fig, human, motifs, kinase, proteins, region, kda, signaling, shown, binds, tcrζcd, phosphorylation, vav, tyrosine, lysates, residue, article, view, binding, murine, expressed, domains, rudd, ligation, pfyn, myeloid, shlike, fusion, analysis, boston, cancer, biol,
Topics {✒️}
arg-xaa-pro-xaa-xaa-pro pro-xaa-xaa-pro-xaa-arg lysine/glutamic acid-rich clusters cell-hybridoma-derived cdna library tonsil-derived cdna library full-length cdna clone authors affiliations antonio gst–sh2/slp-76 fusion protein gst–sh2-slp-76 fusion protein central proline-rich region dana–farber cancer institute social media facebook full-length fyb cdna elegans sh3-carrying-protein ha-tagged fyb cdna jan-willem van ittersum potential downstream link [32p]dctp-labeled fyb slp-76-mediated effects depend βd–βe intervening region hematopoietic-cell northern blot anti-cd3 mab stimulates glutathione s-transferase ha βd region glycine-tyrosine anti-phosphotyrosine mab 4g10 n-terminal end [fyb current emotional state t-cell protein fyb sophisticated auditory–motor learning hematopoietic-signaling protein slp-76 tonsil-purified b-cells c-terminal sh2 domain proline-rich region anti-fyb blotting showed signaling network initiated tyrosine-based motifs modulates interleukin 2 production downstream protein sh2-domain amino acid composition proof musci national academy potential functional motifs librarian recommend pnas amino acid sequences protein-tyrosine kinases slp-76-sh2 domain precipitates download pdf regulates il-2 secretion proline-based type pnas highlights newsletter
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