
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Protein degraders enter the clinic – a new approach to cancer therapy - PMC
Description:
Heterobifunctional protein degraders constitute a novel therapeutic modality that harnesses the cell’s natural protein degradation machinery, that is, the ubiquitin–proteasome system, to selectively target proteins involved in disease pathogenesis ...
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Keywords {🔍}
protein, doi, google, scholar, degraders, cancer, pubmed, degradation, degrader, patients, pmc, clinical, article, free, target, phase, treatment, data, cell, tumour, chem, bavdegalutamide, btk, arv, activity, resistance, dose, ligase, inhibitors, mgkg, growth, proteins, targeted, prostate, presented, breast, development, prior, preclinical, protac, study, targeting, inhibition, receptor, daily, cells, smallmolecule, med, molecules, model,
Topics {✒️}
bcl-xl-dependent t-cell lymphoma103 bell-shaped dose–response curve anti-apoptotic protein bcl-xl ar-expressing patient-derived xenograft pan-essential gene product circulating cell-free dna ss18−ssx1 fusion-positive her2-negative breast cancer er+/her2− locally advanced er+/her2- locally advanced advanced-stage synovial sarcoma selectively degrades bcl-xl advanced-stage prostate cancer bcr-abl1-targeted therapies proximity-inducing small molecule octanol–water partition coefficient decreased bcl-xl proteolysis protac-mediated ternary complexes imid-based/crbn-recruiting degraders e1 ubiquitin-activating enzyme progression-free survival data pretreatment bcl-xl expression ibruitinib-resistant dlbcl cells96 ntrk fusion-positive cancers intracellular ubiquitin–proteasome machinery serine/threonine protein kinase proteolysis-targeting chimeric molecules e2 ubiquitin-conjugating enzyme dt2216 depleted bcl-xl castration-resistant prostate cancer x-ray crystal structures relapsed/refractory b-cell malignancies pmc beta search er-dependent breast cancer65 achieve half-maximal degradation bcl-xl-specific degrader proteolysis-targeting chimera molecules bcl-xl degrader dt2216 wild-type/amplified tumour median progression-free survival clinical-stage brd9 degrader myd88-mutant dlbcl cell induced protein–protein interactions enzalutamide-resistant vcap model39 ar t878a/h875y-positive patient macroautophagy degradation-targeting chimeras small-molecule’ protein degraders structure-based protac design er-targeting protein degrader targeting bcr-abl1
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- Earnings of https://www.nlm.nih.gov/accessibility.html
- Get to know https://www.nlm.nih.gov/careers/careers.html's earnings
- What is the earnings of https://www.nlm.nih.gov/?
- What is the monthly revenue of https://www.nih.gov/?
- How much does https://www.hhs.gov/ rake in every month?
- Profit of https://www.usa.gov/
Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi