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pubmed, mutations, cancer, article, mutants, google, scholar, receptor, prostate, enzalutamide, androgen, patients, cas, table, bicalutamide, additional, crpc, resistance, cfdna, fig, assay, file, data, binding, activation, vpc, cells, dna, mutation, central, identified, activity, sequencing, agonist, wildtype, results, concentrations, treatment, site, progesterone, reported, samples, lbd, including, dht, detected, analysis, hydroxyflutamide, previously, abs,

Topics {✒️}

author information authors reporter plasmid parr3-tk-luciferase springer nature circulating cell-free dna castration-resistant prostate cancer 10 % sds-page gel uk/ena/data/view/prjeb12109 castration-resistant tumor growth cell-free tumor dna castrate-resistant prostate cancer cihr/terry fox foundation hormone-refractory prostate cancer cell-free nucleic acids pdf 345 kb transform current anti-androgens abbreviations abs generation anti-androgens hydroxyflutamide state privacy rights androgen-independent prostate cancer advanced-stage prostatic carcinoma nuclear receptor-binding motif optimem serum-free media abiraterone-resistant prostate cancer dose-response curve illustrating luciferase-reporter transcription assay 7-methyl-1h-indol-3-yl integrative clinical genomics promote androgen-independent growth mutation-dependent drug resistance c-terminal lbd portion integrative genomics viewer lethal castration-resistant overcoming mutation-based resistance multiple amino-acid substitutions synergy-4 multi-plate reader vitro cell-based assay androgen-receptor signaling axis anti-androgen therapy due lncap cell line experimental methods comply canonical hydroxyflutamide-resistant t878a systematic structure-function analysis older anti-androgens ar-dependent luciferase activity low-quality sequencing data wt ar activity ± sem wild-type ar plasmid privacy choices/manage cookies metastatic castration-resistance double mutant f877l/t878a

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            address:
               name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
            name:Laboratory for Advanced Genome Analysis (LAGA)
            address:
               name:Laboratory for Advanced Genome Analysis (LAGA), Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Artem Cherkasov
      affiliation:
            name:University of British Columbia
            address:
               name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
      name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
      name:Laboratory for Advanced Genome Analysis (LAGA), Vancouver, Canada
      name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
      name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
      name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
      name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
      name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
      name:Department of Medical Oncology, BC Cancer Agency, Vancouver, Canada
      name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
      name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
      name:Laboratory for Advanced Genome Analysis (LAGA), Vancouver, Canada
      name:Department of Medical Oncology, BC Cancer Agency, Vancouver, Canada
      name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
      name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
      name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
      name:Laboratory for Advanced Genome Analysis (LAGA), Vancouver, Canada
      name:Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada

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