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Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

cells, degradation, cancer, pdl, fig, doi, pubmed, google, scholar, protein, egfr, free, abfa, data, antibody, cell, tumor, pmc, article, supplementary, proteins, frtac, mice, frtacs, treated, mouse, folate, expression, target, uptake, degrader, level, receptor, targeting, degraders, targets, treatment, antirabbit, ctxfa, efficiency, pbs, membrane, results, significant, source, mgkg, extracellular, drug, hela, tissues,

Topics {✒️}

gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-mirvetuximab-soravtansine-gynx-fra-positive-platinum-resistant mirvetuximab soravtansine-gynx platinum-resistant epithelial ovarian author contributions dissolving α-cyano-4-hydroxycinnamic acid cation-independent mannose-6-phosphate receptor caveolae/lipid-raft-mediated endocytosis folic-acid-based receptor targeting folate-tethered drugs competing interests fa-fitc/fr binary complexes prostate-specific membrane antigen55 atz-fa targeting pd-l1 anti-mouse pd-l1 antibody follicle-stimulating hormone receptor folate receptor-positive cancer secondary hrp-linked antibodies pmc beta search triantennary n-acetylgalactosamine conjugates peer review file proteolysis-targeting chimeric molecules footnotes publisher folic acid-peg1k-n3 folic acid-peg2k-n3 slowfade-antifade mounting medium folic acid-pegn-n3 plasmid expressing flag-fr1 high-glucose dmem supplemented hrp-conjugated secondary antibody dbco-peg3-nhs ester proximity-inducing small molecules transiently overexpressing fr1-flag supplementary information files targeting fa-conjugated igg folate-pegn-nhs ester step labeling methods detecting pd-l1 level data availability statements data availability statement 2k-peg-linker introduced 100 ng/ml mouse ifnγ license information pmcid fr/fa-fitc/anti-fitc-594 folate receptor-expressing tumors low-glucose dmem supplemented antibody-based degrader ab-fa 100 ng/ml human ifnγ insufficient fr-mediated targeting frtac targeting pd-l1 11 mg/kg free fa

Questions {❓}

• The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander?

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