Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://www.dovepress.com/hsp90-inhibitor-nms-e973-exerts-the-anticancer-effect-against-glioblas-peer-reviewed-fulltext-article-OTT, but it redirected us to https://www.dovepress.com/hsp90-inhibitor-nms-e973-exerts-the-anticancer-effect-against-glioblas-peer-reviewed-fulltext-article-OTT. The analysis below is for the second page.

Title[redir]:
Hsp90 inhibitor NMS-E973 exerts the anticancer effect against glioblas | OTT
Description:
Hsp90 inhibitor NMS-E973 exerts the anticancer effect against glioblastoma via induction of PUMA-mediated apoptosis Libo Sun,1 Shoujun Yang,2 Guonan Chi,1 Xingyi Jin1 1First Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changhun, Jilin, People’s Republic of China; 2Department of Rehabilitation, China-Japan Union Hospital of Jilin University, Changhun, Jilin, People’s Republic of China Background: Glioblastoma is one of the most aggressive and common malignancies of the central nervous system in humans. Owing to the correlation of high Hsp90 expression with prognosis and clinical pathology features of diverse types of cancer, targeting Hsp90 with small-molecule inhibitors has become a promising anticancer strategy.Purpose: In this study, we aimed to explore the possibility of anticancer effect of NMS-E973 in giloblastoma and elucidate the mechanism.Methods: Cell based MTT assay and colony formation assay were used to detect cell viability. Apoptosis was analyzed by nuclear staining with Hoechst 33258 and Annexin V/propidium iodide staining followed by flow cytometry. Western-blot and RT-PCR were used to detect gene expression. Xenograft assay was used to explore the anticancer effect of NMS-E973 in vivo.Results: We found that NMS-E973 induces apoptosis and inhibits cell growth in glioblastoma cells in cell culture and xenograft models. As a proapoptotic Bcl-2 member, PUMA was induced by NMS-E973 in a p53-dependent manner in glioblastoma in cell culture, thereby inducing apoptosis in glioblastoma cells. Furthermore, PUMA was induced by NMS-E973 treatment in xenograft tumors, and deficiency in PUMA significantly suppressed the antitumor effects of NMS-E973.Conclusion: Our study suggests that PUMA-mediated apoptosis is important for the therapeutic responses of NMS-E973. Induction of PUMA might be a potential biomarker for predicting NMS-E973 responses. Keywords: NMS-E973, PUMA, glioblastoma, apoptosis

Matching Content Categories {📚}

  • Social Networks
  • Science
  • Education

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 75,586,609 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

We can't figure out the monetization strategy.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Doi.org might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

article, press, medical, dove, published, work, authors, retracted, images, author, open, learn, download, terms, informa, reprints, access, journals, peer, review, permission, publication, editor, figure, plc, contact, testimonials, favored, login, scientific, research, editorial, policies, guidelines, papers, manuscript, journal, oncotargets, therapy, volume, original, hsp, nmse, apoptosis, sun, yang, chi, jin, pdf, supplementary,

Topics {✒️}

editorial policies including fast-track processing dove medical press manuscript login favored authors cope guidelines offer real benefits onco targets ther mol cancer ther academic publishing division london sw1p 1wg uk vat group specific author published article papers review informa plc nms-e973 articles published author medical journals retracted article published work unrelated article editor requested satisfactory explanation approved publication full terms published journals » oncotargets scientific journal alerts pharmaceutical industry anticancer effect s160813 checked journal oncotargets scholarly record decision-making remain online digitally watermarked properly attributed opinions expressed necessarily reflect rights reserved site 5 howick place figure 6e figure 6c editor article

Questions {❓}

  • Why publish with us?

Social Networks {👍}(9)

External Links {🔗}(54)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Tag Manager
  • Google Universal Analytics

Libraries {📚}

  • jQuery

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Com/cm/ef49a3f1-d8c1-47d6-88fc-50e41130631f/airgap

6.58s.