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Title[redir]:
Involvement of Both Extrinsic and Intrinsic Apoptotic Pathways in Tridecylpyrrolidine-Diol Derivative-Induced Apoptosis In Vitro - PMC
Description:
Despite the decreasing trend in mortality from colorectal cancer, this disease still remains the third most common cause of death from cancer. In the present study, we investigated the antiproliferative and pro-apoptotic effects of ...
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Keywords {🔍}
cells, doi, cell, hct, caco, apoptosis, google, scholar, pubmed, pyrrolidine, figure, apoptotic, cancer, usa, treatment, bcl, analysis, proteins, data, significant, caspase, death, proapoptotic, pmc, assay, expression, pathway, mitochondrial, activation, tested, activity, cytochrome, increase, article, showed, colorectal, membrane, table, incubation, free, lines, observed, release, effects, derivative, experiments, analyzed, mtt, μmoll, open,
Topics {✒️}
informed consent statement anti-oncological active spiro-alkaloids pmc beta search dnr bio-imaging systems pro-apoptotic receptor agonists tnf-related apoptosis-inducing ligand asp-glu-val-asp represent multi-functional proteins annexin v-fitc/pi staining anti-inflammatory anti-oxidant dean–jett–fox model writing—original draft preparation pyrrolidine dithiocarbamate/cu complex anti-apoptotic proteins bcl-xl death-inducing signaling complex anti-brdu peroxidase conjugate anti-proliferative assays revealed real-time pcr primers tridecylpyrrolidine-diol derivative-induced apoptosis apoptotic protease-activating factor-1 pro-apoptotic/death ligands [31] real-time pcr analysis cell cycle arrest executioner pro-apoptotic subfamilies cancerous cells mcf-10a pyrrolidine-induced cell death multi-protein complex bad-mediated apoptotic pathway rt-pcr analysis showed cell-extrinsic apoptotic cascade anti-apoptotic bcl-2 proteins anti-apoptotic proteins bcl-2 executioner pro-apoptotic proteins scratch/wound healing assay executioner pro-apoptotic bad significant time-dependent accumulation pro-apoptotic protease procaspase-8 ros-independent jnk activation western blot showed cancerous mcf-10a anti-apoptotic caco-2 gene double ao/pi staining data availability statements bcl-2/bax heterodimer triggered shown anti-migratory activity western blot analysis pro-apoptotic gene faslg ao/pi fluorescent staining publisher site pdf flow cytometric analysis
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