TANDFONLINE . COM {}

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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$42,000 per month
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Keywords {🔍}

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Topics {✒️}

cancer stem cell twitter page taylor open francis group retinoid signaling target breast cscs receive personalised research date register regulate cscs activity identified gene sets journals books breast cscs cell lines differentiation article https enzymatic activity register add cart home search julien wicinski nathalie cervera florence monville pascal finetti françois bertucci published online hypothesis implicates therapeutic approaches targeted therapies recently reported aldelfuor assay isolate normal primary tumors tumorsphere assay contact newsroom email sign taylor england & wales sw1p 1wg csc population journal pathways target csc skip show pages 3297-3302 //doi org/10 4161/cc window

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            name:Retinoid signaling regulates breast canc ....
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      name:Retinoid signaling regulates breast cancer stem cell differentiation
      headline:Retinoid signaling regulates breast cancer stem cell differentiation
      abstract:The cancer stem cell (CSC) hypothesis implicates the development of new therapeutic approaches to target the CSC population. Characterization of the pathways that regulate CSCs activity will facilitate the development of targeted therapies. We recently reported that the enzymatic activity of ALDH1, as measured by the ALDELFUOR assay, can be utilized to isolate normal and malignant breast stem cells in both primary tumors and cell lines. In this study, utilizing a tumorsphere assay, we have demonstrated the role of retinoid signaling in the regulation of breast CSCs self-renewal and differentiation. Utilizing the gene set enrichment analysis (GSEA) algorithm we identified gene sets and pathways associated with retinoid signaling. These pathways regulate breast CSCs biology and their inhibition may provide novel therapeutic approaches to target breast CSCs.
      description:The cancer stem cell (CSC) hypothesis implicates the development of new therapeutic approaches to target the CSC population. Characterization of the pathways that regulate CSCs activity will facilitate the development of targeted therapies. We recently reported that the enzymatic activity of ALDH1, as measured by the ALDELFUOR assay, can be utilized to isolate normal and malignant breast stem cells in both primary tumors and cell lines. In this study, utilizing a tumorsphere assay, we have demonstrated the role of retinoid signaling in the regulation of breast CSCs self-renewal and differentiation. Utilizing the gene set enrichment analysis (GSEA) algorithm we identified gene sets and pathways associated with retinoid signaling. These pathways regulate breast CSCs biology and their inhibition may provide novel therapeutic approaches to target breast CSCs.
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            name:François Bertucci
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            name:Pascal Finetti
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            name:Julien Wicinski
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            name:Daniel Birnbaum
            type:Person
            name:Christophe Ginestier
            type:Person
            name:Florence Monville
            type:Person
            name:Nathalie Cervera
            type:Person
            name:Christophe Ginestier
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      datePublished:2009-10-15
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      name:Daniel Birnbaum
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