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Title:
Metabolic Messengers: ceramides | Nature Metabolism
Description:
Ceramides are products of metabolism that accumulate in individuals with obesity or dyslipidaemia and alter cellular processes in response to fuel surplus. Their actions, when prolonged, elicit the tissue dysfunction that underlies diabetes and heart disease. Here, we review the history of research on these enigmatic molecules, exploring their discovery and mechanisms of action, the evolutionary pressures that have given them their unique attributes and the potential of ceramide-reduction therapies as treatments for cardiometabolic disease. Ceramides are bioactive lipids that regulate cellular signalling processes and metabolic pathways, and are implicated in various metabolic diseases. Here, Summers, Chaurasia and Holland provide a concise overview of the history of ceramides and their physiological roles, mechanisms of action and therapeutic potential.
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nature portfolio journals permissions reprints nature portfolio privacy policy metabolic syndrome development obesity-induced cers6-dependent c16 org/2013meeting/abstracts/fulltext/f130122450 advertising diabetes research center author information authors social media diet-induced hamster model nature+ nature 544 nature lipid-induced insulin resistance research obesity-induced insulin resistance hepatic vldl-apob100 overproduction molecular lipid species author correspondence caveolin-enriched microdomains represents cholesterol/sphingolipid enriched microdomains fat-induced insulin resistance cers6-derived sphingolipids interact tumor necrosis factor-alpha fatty acid binding personal data reduced hepatic steatosis diet-induced obesity gut-liver axis hyperlipidemic apoe-deficient mice diet-induced steatohepatitis data protection obese insulin-resistant humans permissions springerlink instant access ceramide-induced autophagy ceramide-induced apoptosis apolipoprotein e-knockout mice higher ceramide content alter cellular processes chronic heart failure saturated fatty acids ceramide-reduction therapies metabolic messengers hepatic insulin resistance /2016/07/28/ceramides-plasma-a-test skeletal muscle triglycerides serine palmitoyltransferase overexpression
Questions {β}
- Ceramide-mediated apoptosis of hepatocytes in vivo: a matter of the nucleus?
- Could ceramides become the new cholesterol?
- Does this Schlank make me look fat?
- PAQRs: a counteracting force to ceramides?
- Plasma deoxysphingolipids: a novel class of biomarkers for the metabolic syndrome?
- Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?
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