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We are analyzing https://www.nature.com/articles/s41598-018-24624-4.

Title:
Phenotypic variability between Social Dominance Ranks in laboratory mice | Scientific Reports
Description:
The laboratory mouse is the most prevalent animal used in experimental procedures in the biomedical and behavioural sciences. Yet, many scientists fail to consider the animals’ social context. Within a cage, mice may differ in their behaviour and physiology depending on their dominance relationships. Therefore, dominance relationships may be a confounding factor in animal experiments. The current study housed male and female C57BL/6ByJ mice in same-sex groups of 5 in standard laboratory conditions and investigated whether dominance hierarchies were present and stable across three weeks, and whether mice of different dominance ranks varied consistently in behaviour and physiology. We found that dominance ranks of most mice changed with time, but were most stable between the 2nd and 3rd week of testing. Phenotypic measures were also highly variable, and we found no relation between dominance rank and phenotype. Further, we found limited evidence that variation in measures of phenotype was associated with cage assignment for either males or females. Taken together, these findings do not lend support to the general assumption that individual variation among mice is larger between cages than within cages.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

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Content Management System {📝}

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Custom-built

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🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,554,915 visitors per month in the current month.

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$536,300 per month
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Keywords {🔍}

dominance, mice, rank, article, google, scholar, social, cage, ranks, male, pubmed, hierarchies, week, behaviour, weeks, males, females, cages, ordinal, test, groups, measures, assignment, hierarchy, female, variation, behav, task, relationships, object, cas, linear, laboratory, open, mouse, stable, individual, time, linearity, nature, group, body, phenotypic, evidence, mass, fig, brain, animal, research, dominant,

Topics {✒️}

nature portfolio privacy policy editing nature 191 nature advertising social media reprints middle ad libitum access author information authors european research council potential cross-species correlations object discrimination index social decision-making network running wheel-igloo enrichment permissions original author behavioural research full size image steepness index reflects author correspondence limited research general cognitive abilities methods experimental design medial prefrontal cortex female c57bl/6byj mice male dba/2j mice entering open arms temporary access recent research research project research leading social context-dependent relationships linear mixed-effects models faecal glucocorticoid metabolites basal glucocorticoid metabolites open arms compared steepness index standard rodent chow received funding group-housed male cd-1 privacy published maps individual boli samples social dominance suggests cantonal veterinary office network motif architecture explore content home-cage dominance behaviour

Questions {❓}

  • Are there preexisting behavioral characteristics that predict the dominant status of male NIH mice (Mus musculus)?
  • What does the tube test measure?

Schema {🗺️}

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      headline:Phenotypic variability between Social Dominance Ranks in laboratory mice
      description:The laboratory mouse is the most prevalent animal used in experimental procedures in the biomedical and behavioural sciences. Yet, many scientists fail to consider the animals’ social context. Within a cage, mice may differ in their behaviour and physiology depending on their dominance relationships. Therefore, dominance relationships may be a confounding factor in animal experiments. The current study housed male and female C57BL/6ByJ mice in same-sex groups of 5 in standard laboratory conditions and investigated whether dominance hierarchies were present and stable across three weeks, and whether mice of different dominance ranks varied consistently in behaviour and physiology. We found that dominance ranks of most mice changed with time, but were most stable between the 2nd and 3rd week of testing. Phenotypic measures were also highly variable, and we found no relation between dominance rank and phenotype. Further, we found limited evidence that variation in measures of phenotype was associated with cage assignment for either males or females. Taken together, these findings do not lend support to the general assumption that individual variation among mice is larger between cages than within cages.
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