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Title:
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape | Nature Immunology
Description:
Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in 2,734 high-confidence interactions. 90% of these interactions are unreported so far, and our survey therefore illuminates a far wider activity spectrum of ISGs than is currently known. Integration of the resulting ISG-interaction network with published datasets and functional studies allowed us to identify regulators of immunity and processes related to the immune system. Given the extraordinary robustness of the innate immune system, this ISG network may serve as a blueprint for therapeutic targeting of cellular systems to efficiently fight viral infections. Interferon-stimulated genes (ISGs) are a key component of the antiviral response. Pichlmair and colleagues generate a comprehensive ISG interactome that sheds light on their functions in antiviral responses.
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headline:A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape
description:Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in 2,734 high-confidence interactions. 90% of these interactions are unreported so far, and our survey therefore illuminates a far wider activity spectrum of ISGs than is currently known. Integration of the resulting ISG-interaction network with published datasets and functional studies allowed us to identify regulators of immunity and processes related to the immune system. Given the extraordinary robustness of the innate immune system, this ISG network may serve as a blueprint for therapeutic targeting of cellular systems to efficiently fight viral infections. Interferon-stimulated genes (ISGs) are a key component of the antiviral response. Pichlmair and colleagues generate a comprehensive ISG interactome that sheds light on their functions in antiviral responses.
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name:Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Munich, Germany
type:PostalAddress
type:Organization
name:Charles M. Rice
affiliation:
name:The Rockefeller University
address:
name:Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, USA
type:PostalAddress
type:Organization
name:Andreas Pichlmair
url:http://orcid.org/0000-0002-0166-1367
affiliation:
name:Max-Planck Institute of Biochemistry
address:
name:Innate Immunity Laboratory, Max-Planck Institute of Biochemistry, Munich, Germany
type:PostalAddress
type:Organization
name:Technical University of Munich
address:
name:Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany
type:PostalAddress
type:Organization
name:German Center for Infection Research (DZIF) Munich Partner Site
address:
name:German Center for Infection Research (DZIF) Munich Partner Site, Munich, Germany
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Innate Immunity Laboratory, Max-Planck Institute of Biochemistry, Munich, Germany
name:Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany
name:Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany
name:Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, USA
name:Innate Immunity Laboratory, Max-Planck Institute of Biochemistry, Munich, Germany
name:Innate Immunity Laboratory, Max-Planck Institute of Biochemistry, Munich, Germany
name:Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany
name:Innate Immunity Laboratory, Max-Planck Institute of Biochemistry, Munich, Germany
name:Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany
name:Innate Immunity Laboratory, Max-Planck Institute of Biochemistry, Munich, Germany
name:Institute of Virology, Westfaelische Wilhelms-University Muenster, Muenster, Germany
name:Cluster of Excellence รขยยCells in Motionรขยย, Westfaelische Wilhelms-University Muenster, Muenster, Germany
name:Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, USA
name:Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, USA
name:Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, USA
name:Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany
name:Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Munich, Germany
name:Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, USA
name:Innate Immunity Laboratory, Max-Planck Institute of Biochemistry, Munich, Germany
name:Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany
name:German Center for Infection Research (DZIF) Munich Partner Site, Munich, Germany
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