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Title:
The machineries, regulation and cellular functions of mitochondrial calcium | Nature Reviews Molecular Cell Biology
Description:
Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they have many physiological functions, prominently including muscle contraction, neuronal excitability, cell migration and cell growth. By sequestering and releasing Ca2+, mitochondria serve as important regulators of cellular Ca2+. Mitochondrial Ca2+ also has other important functions, such as regulation of mitochondrial metabolism, ATP production and cell death. In recent years, identification of the molecular machinery regulating mitochondrial Ca2+ accumulation and efflux has expanded the number of (patho)physiological conditions that rely on mitochondrial Ca2+ homeostasis. Thus, expanding the understanding of the mechanisms of mitochondrial Ca2+ regulation and function in different cell types is an important task in biomedical research, which offers the possibility of targeting mitochondrial Ca2+ machinery for the treatment of several disorders. Uptake of Ca2+ ions by mitochondria regulates their functions and serves to buffer Ca2+ concentrations to maintain cellular Ca2+ homeostasis. Better understanding of the mechanisms, regulation and (patho)physiology of mitochondrial Ca2+ influx and efflux offers the possibility to target mitochondrial Ca2+ machineries for therapeutic benefit.
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permissions reprints cation-selective open state nature portfolio journals privacy policy nature portfolio voltage-dependent anion channel advertising mitochondrial atp-mg/pi transporter dominant-negative pore-forming subunit n-methyl-d-aspartate receptors voltage-dependent anion channels /calmodulin-dependent kinase ii social media open configuration mia40-induced micu1-micu2 dimer p53-mutant cancers jonathan pyk2-dependent tyrosine phosphorylation store-operated ca2+ entry limiting ca2+-induced nad endoplasmic reticulum-targeted “cameleons” cancer research modulates permeability transition store-operated calcium channels store-operated ca2+ channels l-type ca2+ channel ca2+-dependent gene expression leucine zipper-ef-hand fccp-sensitive ca2+ store biomedical research body mcu-knockout mice frequency-dependent mitochondrial ca long-term metabolic priming glucose-induced atp increases multiple ef-hand domains mitochondrial-dependent cell death passive ca2+/2h+ exchanger mitochondrial protein fus1/tusc2 ca2+-induced ca2+ release pancreatic islet beta-cells mitochondrial permeability transition bcl-2 homologous antagonist/killer glucose-induced membrane recruitment alpha-synuclein binds calcium-dependent mitochondrial function mcu-mediated mitochondrial ca clonal pancreatic beta-cells high-affinity cooperative ca aequorin-based fluorescent indicator akap121-anchored signaling complex voltage gated ca
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- Mitochondrial Ca2+ uptake: tortoise or hare?
- The Warburg effect: how does it benefit cancer cells?
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