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We are analyzing https://www.nature.com/articles/s41580-018-0052-8.

Title:
The machineries, regulation and cellular functions of mitochondrial calcium | Nature Reviews Molecular Cell Biology
Description:
Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they have many physiological functions, prominently including muscle contraction, neuronal excitability, cell migration and cell growth. By sequestering and releasing Ca2+, mitochondria serve as important regulators of cellular Ca2+. Mitochondrial Ca2+ also has other important functions, such as regulation of mitochondrial metabolism, ATP production and cell death. In recent years, identification of the molecular machinery regulating mitochondrial Ca2+ accumulation and efflux has expanded the number of (patho)physiological conditions that rely on mitochondrial Ca2+ homeostasis. Thus, expanding the understanding of the mechanisms of mitochondrial Ca2+ regulation and function in different cell types is an important task in biomedical research, which offers the possibility of targeting mitochondrial Ca2+ machinery for the treatment of several disorders. Uptake of Ca2+ ions by mitochondria regulates their functions and serves to buffer Ca2+ concentrations to maintain cellular Ca2+ homeostasis. Better understanding of the mechanisms, regulation and (patho)physiology of mitochondrial Ca2+ influx and efflux offers the possibility to target mitochondrial Ca2+ machineries for therapeutic benefit.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Business & Finance
  • Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,554,915 visitors per month in the current month.

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How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

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Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$536,300 per month
Estimations show Nature.com's display ad online revenue falls between $357,503 and $983,134 per month.

Keywords {🔍}

pubmed, article, google, scholar, cas, mitochondrial, central, calcium, cell, uniporter, biol, nature, mitochondria, sci, complex, nat, protein, mol, uptake, mcu, homeostasis, rep, proc, natl, acad, usa, chem, regulates, heart, death, channels, cardiac, micu, study, cells, membrane, molecular, reticulum, role, coupling, regulation, biophys, acta, endoplasmic, pinton, channel, biochim, function, signalling, disease,

Topics {✒️}

permissions reprints cation-selective open state nature portfolio journals privacy policy nature portfolio voltage-dependent anion channel advertising mitochondrial atp-mg/pi transporter dominant-negative pore-forming subunit n-methyl-d-aspartate receptors voltage-dependent anion channels /calmodulin-dependent kinase ii social media open configuration mia40-induced micu1-micu2 dimer p53-mutant cancers jonathan pyk2-dependent tyrosine phosphorylation store-operated ca2+ entry limiting ca2+-induced nad endoplasmic reticulum-targeted “cameleons” cancer research modulates permeability transition store-operated calcium channels store-operated ca2+ channels l-type ca2+ channel ca2+-dependent gene expression leucine zipper-ef-hand fccp-sensitive ca2+ store biomedical research body mcu-knockout mice frequency-dependent mitochondrial ca long-term metabolic priming glucose-induced atp increases multiple ef-hand domains mitochondrial-dependent cell death passive ca2+/2h+ exchanger mitochondrial protein fus1/tusc2 ca2+-induced ca2+ release pancreatic islet beta-cells mitochondrial permeability transition bcl-2 homologous antagonist/killer glucose-induced membrane recruitment alpha-synuclein binds calcium-dependent mitochondrial function mcu-mediated mitochondrial ca clonal pancreatic beta-cells high-affinity cooperative ca aequorin-based fluorescent indicator akap121-anchored signaling complex voltage gated ca

Questions {❓}

  • Mitochondrial Ca2+ uptake: tortoise or hare?
  • The Warburg effect: how does it benefit cancer cells?

Schema {🗺️}

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External Links {🔗}(891)

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