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Title:
Transdermal microneedles for the programmable burst release of multiple vaccine payloads | Nature Biomedical Engineering
Description:
Repeated bolus injections are associated with higher costs and poor compliance and can hinder the implementation of global immunization campaigns. Here, we report the development and preclinical testing of patches of transdermal core–shell microneedles—which were fabricated by the micromoulding and alignment of vaccine cores and shells made from poly(lactic-co-glycolic acid) with varying degradability kinetics—for the preprogrammed burst release of vaccine payloads over a period of a few days to more than a month from a single administration. In rats, microneedles loaded with a clinically available vaccine (Prevnar-13) against the bacterium Streptococcus pneumoniae induced immune responses that were similar to immune responses observed after multiple subcutaneous bolus injections, and led to immune protection against a lethal bacterial dose. Microneedle patches delivering preprogrammed doses may offer an alternative strategy to prophylactic and therapeutic protocols that require multiple injections. Patches of transdermal core–shell microneedles, fabricated via additive manufacturing of polymer shells with varying degradability kinetics, enable the preprogrammed burst release of vaccine payloads over a period of a few days to more than a month.
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pubmed, article, google, scholar, cas, nature, delivery, central, vaccine, usa, drug, microneedle, engineering, microneedles, release, access, university, data, content, transdermal, research, information, biomedical, nat, connecticut, york, cookies, nguyen, injections, immunization, patches, patch, skin, supplementary, vaccination, center, department, privacy, vaccines, world, health, sci, adv, mater, fabrication, science, materials, storrs, journal, multiple,
Topics {✒️}
nature portfolio journals permissions reprints nature portfolio privacy policy advertising social media author information authors animal research research studies nature+ nature 342 nature 389 nature development africa microneedle patch-assisted delivery iontophoresis-driven microneedle patch long-acting reversible contraception multi-pulse drug delivery research author correspondence rapidly-dissolvable microneedle patches custom-built alignment device microneedle-array patches loaded main data supporting including source data transdermal core–shell microneedles permissions pneumococcal conjugate vaccine biomedical engineering springerlink instant access controlled drug delivery effervescent microneedle patch mechanical engineering immune responses observed soil microbiota elicits published maps single-injection vaccines transdermal sustained delivery transdermal drug delivery require multiple injections active transdermal delivery privacy lithography-based methods large microneedle patches biomimetic electroactive materials multiple vaccine payloads roxana piotrowska preprogrammed burst release implantable polymeric microneedles
Questions {❓}
- Can needle-free administration of vaccines become the norm in global immunization?
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