
NATURE . COM {
}
Title:
Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death | Nature Communications
Description:
Induction of tumor cell death is the therapeutic goal for most anticancer drugs. Yet, a mode of drug-induced cell death, known as immunogenic cell death (ICD), can propagate antitumoral immunity to augment therapeutic efficacy. Currently, the molecular hallmark of ICD features the release of damage-associated molecular patterns (DAMPs) by dying cancer cells. Here, we show that gemcitabine, a standard chemotherapy for various solid tumors, triggers hallmark immunostimualtory DAMP release (e.g., calreticulin, HSP70, and HMGB1); however, is unable to induce ICD. Mechanistic studies reveal gemcitabine concurrently triggers prostaglandin E2 release as an inhibitory DAMP to counterpoise the adjuvanticity of immunostimulatory DAMPs. Pharmacological blockade of prostaglandin E2 biosythesis favors CD103+ dendritic cell activation that primes a Tc1-polarized CD8+ T cell response to bolster tumor rejection. Herein, we postulate that an intricate balance between immunostimulatory and inhibitory DAMPs could determine the outcome of drug-induced ICD and pose COX-2/prostaglandin E2 blockade as a strategy to harness ICD. Most chemotherapeutic agents, including gemcitabine, do not elicit immunogenic cell death, a phenomenon associated with the release of damage-associated molecule patterns (DAMPs). Here, the authors show that gemcitabine-treated dying cancer cells express hallmark DAMPs but their immunogenic properties are hindered by the concomitant release of the inhibitory DAMP PGE2.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Science
- Telecommunications
- Health & Fitness
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$63,100 per month
Estimations show Nature.com's display ad online revenue falls between $42,042 and $115,616 per month.
Keywords {🔍}
cells, cell, fig, cancer, gemcitabine, death, immunogenic, blockade, damps, tumor, release, pge, dendritic, immune, damp, response, vaccination, treatment, expression, supplementary, mice, data, icd, media, chemotherapy, biolegend, analysis, nature, bladder, hallmark, cultured, immunol, immunity, results, assay, article, protein, idamp, murine, flow, immunostimulatory, inhibitory, coxpge, crt, days, bmdcs, antitumoral, surface, panc, control,
Topics {✒️}
nature portfolio privacy policy research design granulocyte–macrophage colony-stimulating factor professional antigen-presenting cells advertising high-throughput qpcr-based platform triggers hallmark immunostimualtory damp release cox-2/pge2-blocked vaccine groups nature https type-1-polarized cd103+ dc/cd8+ reprints nature cox-2/pge2 blockade exhibited drug-induced cell death mass spectrometry-based assays helper t-cell response cedars-sinai medical center hsp heat-shock protein cell death-induced release vaccine-draining lymph nodes tc1-polarized immune response t-cell polarizing effects heat-shock protein 70 kda u-bottom plates coated bona fide icd-inducers17 fluorescence-activated cell sorting low-dose oral cyclophosphamide kaplan–meier survival analysis full size image bona fide icd-vaccine cancer cells pre-treated author information authors g69 bladder cancer model cytometry/cell sorting cores batf3 deficiency reveals l-arginine metabolism antitumoral tc1-polarized immunity cox-2/pge2-blockade groups 1x insulin-transferrin-selenium hallmark antigen-receptor clec9a44 chemotherapy-induced damp release dendritic cell pd-l1 cox-2/pge2-blockade arm live/dead-nearir stain host-derived “danger” signals gemctx-treated cd103+ bmdcs bona fide icd-inducers cyclooxygenase-dependent tumor growth cell expansion/memory formation54
Questions {❓}
- Immunological decision-making: how does the immune system decide to mount a helper T-cell response?
Schema {🗺️}
WebPage:
mainEntity:
headline:Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
description:Induction of tumor cell death is the therapeutic goal for most anticancer drugs. Yet, a mode of drug-induced cell death, known as immunogenic cell death (ICD), can propagate antitumoral immunity to augment therapeutic efficacy. Currently, the molecular hallmark of ICD features the release of damage-associated molecular patterns (DAMPs) by dying cancer cells. Here, we show that gemcitabine, a standard chemotherapy for various solid tumors, triggers hallmark immunostimualtory DAMP release (e.g., calreticulin, HSP70, and HMGB1); however, is unable to induce ICD. Mechanistic studies reveal gemcitabine concurrently triggers prostaglandin E2 release as an inhibitory DAMP to counterpoise the adjuvanticity of immunostimulatory DAMPs. Pharmacological blockade of prostaglandin E2 biosythesis favors CD103+ dendritic cell activation that primes a Tc1-polarized CD8+ T cell response to bolster tumor rejection. Herein, we postulate that an intricate balance between immunostimulatory and inhibitory DAMPs could determine the outcome of drug-induced ICD and pose COX-2/prostaglandin E2 blockade as a strategy to harness ICD. Most chemotherapeutic agents, including gemcitabine, do not elicit immunogenic cell death, a phenomenon associated with the release of damage-associated molecule patterns (DAMPs). Here, the authors show that gemcitabine-treated dying cancer cells express hallmark DAMPs but their immunogenic properties are hindered by the concomitant release of the inhibitory DAMP PGE2.
datePublished:2020-12-07T00:00:00Z
dateModified:2020-12-07T00:00:00Z
pageStart:1
pageEnd:13
license:http://creativecommons.org/licenses/by/4.0/
sameAs:https://doi.org/10.1038/s41467-020-19970-9
keywords:
Bladder cancer
Cell death and immune response
Chemotherapy
Pancreatic cancer
Tumour immunology
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig1_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig2_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig3_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig4_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig5_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig6_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig7_HTML.png
isPartOf:
name:Nature Communications
issn:
2041-1723
volumeNumber:11
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:K. Hayashi
url:http://orcid.org/0000-0003-0325-3719
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
name:Baylor College of Medicine
address:
name:Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:F. Nikolos
url:http://orcid.org/0000-0002-8622-0017
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
type:Person
name:Y. C. Lee
affiliation:
name:Taipei Medical University
address:
name:Graduate Institute of Medical Sciences, Taipei Medical University, Taipei City, Taiwan
type:PostalAddress
type:Organization
type:Person
name:A. Jain
url:http://orcid.org/0000-0002-2815-3645
affiliation:
name:Baylor College of Medicine
address:
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:E. Tsouko
affiliation:
name:Baylor College of Medicine
address:
name:Department of Orthopedic Surgery, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:H. Gao
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
type:Person
name:A. Kasabyan
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
type:Person
name:H. E. Leung
affiliation:
name:Baylor College of Medicine
address:
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:A. Osipov
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
type:Person
name:S. Y. Jung
url:http://orcid.org/0000-0003-1521-7977
affiliation:
name:Baylor College of Medicine
address:
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:A. V. Kurtova
affiliation:
name:Baylor College of Medicine
address:
name:Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:K. S. Chan
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
description:Induction of tumor cell death is the therapeutic goal for most anticancer drugs. Yet, a mode of drug-induced cell death, known as immunogenic cell death (ICD), can propagate antitumoral immunity to augment therapeutic efficacy. Currently, the molecular hallmark of ICD features the release of damage-associated molecular patterns (DAMPs) by dying cancer cells. Here, we show that gemcitabine, a standard chemotherapy for various solid tumors, triggers hallmark immunostimualtory DAMP release (e.g., calreticulin, HSP70, and HMGB1); however, is unable to induce ICD. Mechanistic studies reveal gemcitabine concurrently triggers prostaglandin E2 release as an inhibitory DAMP to counterpoise the adjuvanticity of immunostimulatory DAMPs. Pharmacological blockade of prostaglandin E2 biosythesis favors CD103+ dendritic cell activation that primes a Tc1-polarized CD8+ T cell response to bolster tumor rejection. Herein, we postulate that an intricate balance between immunostimulatory and inhibitory DAMPs could determine the outcome of drug-induced ICD and pose COX-2/prostaglandin E2 blockade as a strategy to harness ICD. Most chemotherapeutic agents, including gemcitabine, do not elicit immunogenic cell death, a phenomenon associated with the release of damage-associated molecule patterns (DAMPs). Here, the authors show that gemcitabine-treated dying cancer cells express hallmark DAMPs but their immunogenic properties are hindered by the concomitant release of the inhibitory DAMP PGE2.
datePublished:2020-12-07T00:00:00Z
dateModified:2020-12-07T00:00:00Z
pageStart:1
pageEnd:13
license:http://creativecommons.org/licenses/by/4.0/
sameAs:https://doi.org/10.1038/s41467-020-19970-9
keywords:
Bladder cancer
Cell death and immune response
Chemotherapy
Pancreatic cancer
Tumour immunology
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig1_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig2_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig3_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig4_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig5_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig6_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_Fig7_HTML.png
isPartOf:
name:Nature Communications
issn:
2041-1723
volumeNumber:11
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:K. Hayashi
url:http://orcid.org/0000-0003-0325-3719
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
name:Baylor College of Medicine
address:
name:Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:F. Nikolos
url:http://orcid.org/0000-0002-8622-0017
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
type:Person
name:Y. C. Lee
affiliation:
name:Taipei Medical University
address:
name:Graduate Institute of Medical Sciences, Taipei Medical University, Taipei City, Taiwan
type:PostalAddress
type:Organization
type:Person
name:A. Jain
url:http://orcid.org/0000-0002-2815-3645
affiliation:
name:Baylor College of Medicine
address:
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:E. Tsouko
affiliation:
name:Baylor College of Medicine
address:
name:Department of Orthopedic Surgery, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:H. Gao
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
type:Person
name:A. Kasabyan
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
type:Person
name:H. E. Leung
affiliation:
name:Baylor College of Medicine
address:
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:A. Osipov
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
type:Person
name:S. Y. Jung
url:http://orcid.org/0000-0003-1521-7977
affiliation:
name:Baylor College of Medicine
address:
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:A. V. Kurtova
affiliation:
name:Baylor College of Medicine
address:
name:Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:K. S. Chan
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
["Periodical","PublicationVolume"]:
name:Nature Communications
issn:
2041-1723
volumeNumber:11
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Cedars-Sinai Medical Center
address:
name:Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
name:Baylor College of Medicine
address:
name:Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, USA
type:PostalAddress
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
name:Taipei Medical University
address:
name:Graduate Institute of Medical Sciences, Taipei Medical University, Taipei City, Taiwan
type:PostalAddress
name:Baylor College of Medicine
address:
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
type:PostalAddress
name:Baylor College of Medicine
address:
name:Department of Orthopedic Surgery, Baylor College of Medicine, Houston, USA
type:PostalAddress
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
name:Baylor College of Medicine
address:
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
type:PostalAddress
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
name:Baylor College of Medicine
address:
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
type:PostalAddress
name:Baylor College of Medicine
address:
name:Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, USA
type:PostalAddress
name:Cedars-Sinai Medical Center
address:
name:Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:K. Hayashi
url:http://orcid.org/0000-0003-0325-3719
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
name:Baylor College of Medicine
address:
name:Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
name:F. Nikolos
url:http://orcid.org/0000-0002-8622-0017
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
name:Y. C. Lee
affiliation:
name:Taipei Medical University
address:
name:Graduate Institute of Medical Sciences, Taipei Medical University, Taipei City, Taiwan
type:PostalAddress
type:Organization
name:A. Jain
url:http://orcid.org/0000-0002-2815-3645
affiliation:
name:Baylor College of Medicine
address:
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
name:E. Tsouko
affiliation:
name:Baylor College of Medicine
address:
name:Department of Orthopedic Surgery, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
name:H. Gao
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
name:A. Kasabyan
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
name:H. E. Leung
affiliation:
name:Baylor College of Medicine
address:
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
name:A. Osipov
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
name:S. Y. Jung
url:http://orcid.org/0000-0003-1521-7977
affiliation:
name:Baylor College of Medicine
address:
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
name:A. V. Kurtova
affiliation:
name:Baylor College of Medicine
address:
name:Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, USA
type:PostalAddress
type:Organization
name:K. S. Chan
affiliation:
name:Cedars-Sinai Medical Center
address:
name:Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
name:Cedars-Sinai Medical Center
address:
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA
name:Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, USA
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
name:Graduate Institute of Medical Sciences, Taipei Medical University, Taipei City, Taiwan
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
name:Department of Orthopedic Surgery, Baylor College of Medicine, Houston, USA
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
name:Alkek Center for Molecular Discovery, Proteomics Core, Baylor College of Medicine, Houston, USA
name:Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, USA
name:Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA
name:Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, USA
Social Networks {👍}(2)
External Links {🔗}(135)
- What's the revenue for https://orcid.org/0000-0003-0325-3719?
- Revenue of https://orcid.org/0000-0002-8622-0017
- Learn about the earnings of https://orcid.org/0000-0002-2815-3645
- What are the total earnings of https://orcid.org/0000-0003-1521-7977?
- How much profit does http://proteomecentral.proteomexchange.org/ make?
- How much does https://massive.ucsd.edu make?
- How much does https://doi.org/10.1016/j.cell.2010.02.014 bring in each month?
- How much does https://doi.org/10.1038/cdd.2015.172 make?
- Learn about the earnings of https://doi.org/10.1038/nri.2016.107
- How much income does https://doi.org/10.1038/nri.2017.9 have?
- What's the monthly income of https://doi.org/10.1146/annurev-immunol-032712-100008?
- How much does https://doi.org/10.1146%2Fannurev-immunol-032712-100008 bring in each month?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23157435 bring in?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Immunogenic%20cell%20death%20in%20cancer%20therapy&journal=Annu.%20Rev.%20Immunol.&doi=10.1146%2Fannurev-immunol-032712-100008&publication_year=2013&author=Kroemer%2CG&author=Galluzzi%2CL&author=Kepp%2CO&author=Zitvogel%2CL?
- How much does https://doi.org/10.1038/nri2545 bring in each month?
- How much profit does https://doi.org/10.1136/jitc-2019-000337 make?
- https://doi.org/10.1136%2Fjitc-2019-000337's total income per month
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32819974 pull in monthly?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443306 make?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Consensus%20guidelines%20for%20the%20definition%2C%20detection%20and%20interpretation%20of%20immunogenic%20cell%20death&journal=J.%20Immunother.%20Cancer&doi=10.1136%2Fjitc-2019-000337&publication_year=2020&author=Galluzzi%2CL
- Earnings of https://doi.org/10.1038/nm1523
- https://doi.org/10.1002/ijc.20249 income
- Revenue of https://doi.org/10.1038/nm1622
- What are the earnings of https://doi.org/10.1038/32588?
- Income figures for https://doi.org/10.1111/j.1600-065X.2012.01146.x
- https://doi.org/10.1038/cmi.2013.59 income
- What's the profit of https://doi.org/10.1126/science.1068883?
- How much revenue does https://doi.org/10.1126%2Fscience.1068883 bring in?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11951031 produce monthly?
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=Decoding%20the%20patterns%20of%20self%20and%20nonself%20by%20the%20innate%20immune%20system&journal=Science&doi=10.1126%2Fscience.1068883&publication_year=2002&author=Medzhitov%2CR&author=Janeway%2CCA
- How much profit does https://doi.org/10.1016/S0092-8674(02)01201-1 generate?
- What's the financial intake of https://doi.org/10.1016/j.canlet.2018.08.028?
- See how much https://doi.org/10.1016%2Fj.canlet.2018.08.028 makes per month
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=30594325 gross monthly?
- What are the earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492280?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Immunogenic%20cell%20death%20in%20anticancer%20chemotherapy%20and%20its%20impact%20on%20clinical%20studies&journal=Cancer%20Lett.&doi=10.1016%2Fj.canlet.2018.08.028&publication_year=2018&author=Wang%2CQ?
- How much money does https://doi.org/10.1080/2162402X.2019.1703449 generate?
- How much revenue does https://doi.org/10.1038/bjc.2017.446 produce monthly?
- What's https://doi.org/10.1038/s41591-019-0432-4's gross income?
- What's https://doi.org/10.1007/s10549-017-4570-4's gross income?
- What's the income of https://doi.org/10.1080/2162402X.2017.1386829?
- How much income does https://doi.org/10.3389/fimmu.2015.00187 have?
- How much does https://doi.org/10.1084/jem.20050915 pull in?
- What's the income generated by https://doi.org/10.1158/0008-5472.CAN-11-0950 each month?
- How much does https://doi.org/10.1038/emboj.2011.497 bring in each month?
- What are the earnings of https://doi.org/10.1038%2Femboj.2011.497?
- Get to know what's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22252128
- How much profit is http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298003 making per month?
- How much money does http://scholar.google.com/scholar_lookup?&title=A%20novel%20pathway%20combining%20calreticulin%20exposure%20and%20ATP%20secretion%20in%20immunogenic%20cancer%20cell%20death&journal=EMBO%20J.&doi=10.1038%2Femboj.2011.497&publication_year=2012&author=Garg%2CAD make?
- https://doi.org/10.1007/978-1-4939-8885-3_21's revenue stream
- What's the revenue for https://doi.org/10.4161/21624011.2014.955691?
- What are the total earnings of https://doi.org/10.18632/oncotarget.2948?
- How much does https://doi.org/10.1038/cdd.2008.67 pull in?
- How much does https://doi.org/10.1126/science.aad0779 pull in?
- Monthly income for https://doi.org/10.1038/cddis.2013.156
- What are the total earnings of https://doi.org/10.1038/nri2215?
- How much does https://doi.org/10.1073/pnas.1602023113 gross monthly?
- Earnings of https://doi.org/10.1038/nature14034
- How much does https://doi.org/10.1038/nri3254 pull in?
- How much does https://doi.org/10.3389/fimmu.2018.01643 net monthly?
- How much does https://doi.org/10.1084/jem.192.12.1685 bring in each month?
- Check the income stats for https://doi.org/10.4049/jimmunol.166.9.5327
- How much does https://doi.org/10.1038/ni.1724 bring in each month?
- What's the revenue for https://doi.org/10.1111/j.0105-2896.2009.00874.x?
- How much does https://doi.org/10.1182/blood-2013-12-545772 make?
- What are the total earnings of https://doi.org/10.1126/science.1164206?
- What's the monthly money flow for https://doi.org/10.1016/j.immuni.2016.08.013?
- See how much https://doi.org/10.1038/nri3712 makes per month
- Learn how profitable https://doi.org/10.1084/jem.20092140 is on a monthly basis
- How much profit is https://doi.org/10.1007/s00018-015-2005-0 making per month?
- How much cash flow does https://doi.org/10.1016/j.immuni.2014.04.016 have monthly?
- See how much https://doi.org/10.1002/embj.201488027 makes per month
- How much cash flow does https://doi.org/10.1016/j.smim.2009.05.010 have monthly?
- How much does https://doi.org/10.1111/j.1365-2567.2007.02719.x pull in?
- How much money does https://doi.org/10.3389/fimmu.2017.01764 generate?
- Get to know what's the income of https://doi.org/10.1038/nri1668
- How much revenue does https://doi.org/10.1182/blood-2006-06-031856 bring in?
- How much does https://doi.org/10.1097/MOT.0b013e3282f3dee1 earn?
- What's the income of https://doi.org/10.4049/jimmunol.178.7.4260?
- Monthly income for https://doi.org/10.1038/nri1349
- How much revenue does https://doi.org/10.1182/blood-2006-11-060087 generate?
- How much does https://doi.org/10.1182/blood-2005-03-0979 bring in each month?
- What's the total monthly financial gain of https://doi.org/10.2217/imt.12.126?
- Check the income stats for https://doi.org/10.1007/s00005-014-0293-y
- How much does https://doi.org/10.4049/jimmunol.167.11.6497 net monthly?
- Find out how much https://doi.org/10.1158/1078-0432.CCR-15-0183 earns monthly
- Monthly income for https://doi.org/10.1016/S0140-6736(20)30230-0
- How much does https://doi.org/10.1016/j.cell.2015.08.015 pull in?
- How profitable is https://doi.org/10.1016/j.cell.2018.01.004?
- https://doi.org/10.1038/s43018-020-0075-x income
- How much does https://doi.org/10.1126/scitranslmed.aav7431 pull in monthly?
- How much money does https://doi.org/10.1080/2162402X.2015.1082706 generate?
- Find out how much https://doi.org/10.1002/ijc.27894 earns monthly
- How much does https://doi.org/10.1016/j.imlet.2017.11.006 net monthly?
- How much does https://doi.org/10.1182/blood-2016-08-731737 pull in monthly?
- What's the monthly income of https://citation-needed.springer.com/v2/references/10.1038/s41467-020-19970-9?format=refman&flavour=references?
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=K.%20Hayashi bring in?
- What's the monthly income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22K.%20Hayashi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=F.%20Nikolos?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22F.%20Nikolos%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Y.%20C.%20Lee's total income per month
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Y.%20C.%20Lee%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earn?
- Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=A.%20Jain is on a monthly basis
- How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22A.%20Jain%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- What's the income generated by https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=E.%20Tsouko each month?
- How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22E.%20Tsouko%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
- What's the monthly income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=H.%20Gao?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22H.%20Gao%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en net monthly?
- Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=A.%20Kasabyan
- What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22A.%20Kasabyan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=H.%20E.%20Leung income
- Find out how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22H.%20E.%20Leung%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earns monthly
- Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=A.%20Osipov
- Revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22A.%20Osipov%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's the financial outcome of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=S.%20Y.%20Jung?
- What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22S.%20Y.%20Jung%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=A.%20V.%20Kurtova produce monthly?
- Financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22A.%20V.%20Kurtova%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=K.%20S.%20Chan
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22K.%20S.%20Chan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en income
- How much does https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_MOESM1_ESM.pdf pull in?
- Check the income stats for https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-020-19970-9/MediaObjects/41467_2020_19970_MOESM2_ESM.pdf
- What is the monthly revenue of http://creativecommons.org/licenses/by/4.0/?
- How much profit does https://s100.copyright.com/AppDispatchServlet?title=Tipping%20the%20immunostimulatory%20and%20inhibitory%20DAMP%20balance%20to%20harness%20immunogenic%20cell%20death&author=K.%20Hayashi%20et%20al&contentID=10.1038%2Fs41467-020-19970-9©right=The%20Author%28s%29&publication=2041-1723&publicationDate=2020-12-07&publisherName=SpringerNature&orderBeanReset=true&oa=CC%20BY make?
- How much does https://crossmark.crossref.org/dialog/?doi=10.1038/s41467-020-19970-9 pull in?
- How much revenue does https://citation-needed.springer.com/v2/references/10.1038/s41467-020-19970-9?format=refman&flavour=citation bring in?
- How much money does https://doi.org/10.1186/s12951-025-03464-1 generate?
- How much income does https://doi.org/10.1186/s12951-024-02417-4 have?
- What's https://doi.org/10.1038/s41392-024-01979-x's gross income?
- How much revenue does https://doi.org/10.1038/s41573-024-00920-9 bring in?
- How much cash flow does https://doi.org/10.1038/s42003-024-07180-8 have monthly?
- What's https://www.protocols.io/'s gross income?
- What are the total earnings of https://www.natureindex.com/?
- What's the revenue for http://www.naturechina.com?
- https://www.natureasia.com/ja-jp's total income per month
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref