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We began analyzing https://www.oncotarget.com/article/2948/text/, but it redirected us to https://www.oncotarget.com/article/2948/text/. The analysis below is for the second page.

Title[redir]:
Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma | Oncotarget
Description:
// Tiansuo Zhao 1,* , He Ren 1,* , Li Jia 2 , Jing Chen 1 , Wen Xin 1 , Fan Yan 1 , Jing Li 1 , Xiuchao Wang 1 , Song Gao 1 , Dong Qian 1 , Chongbiao Huang 1 and Jihui Hao 1 1 Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Pancreatic Cancer, Tianjin, China 2 Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK * These authors contributed equally to this work Correspondence: Jihui Hao, email: // Keywords : Pancreatic ductal adenocarcinoma (PDAC), Immunogenic cell death (ICD), PX-478, Gemcitabine (Gem) Received : October 01, 2014 Accepted : December 09, 2014 Published : December 10, 2014 Abstract Pancreatic ductal adenocarcinoma (PDAC) is the worst prognoses among all the malignancies. Now, gemcitabine (Gem) is the first line chemotherapeutic drug for advanced pancreatic cancer. However, Gem is usually ineffective to the PDAC because of high degree of drug resistance. Hypoxia and immune suppressive milieu are the best-described hallmarks of PDAC; therefore, we investigated the impact of hypoxia inducible factor-1 (HIF-1) inhibitor, PX-478, in combination with Gem on the induction of immunogenic cell death (ICD). We verified that combined treatment with Gem/PX-478 significantly enhanced the anti-tumor effect and increased proportion of tumor infiltrating T-lymphocytes in Panc02-bearing immune-competent but not in immune-deficient mice. Vaccination using Panc02 cell line treated with single agent or in combination showed significant anti-tumor effects. Pancreatic cell lines treated with Gem and PX-478 can induce an increase in eIF2α phosphorylation was correlated with down-regulation of HIF-1α and elicited exposure of CRT and release of HMGB1 and ATP. Only co-treated cells induced DC maturation/phagocytosis and IFN-γ secretion by cytotoxic T lymphocytes. Altogether, combined treatment with Gem/PX-478 showed significantly inhibition on tumor growth and anti-tumor immunization. We propose that inhibition HIF-1α elicits Gem-induced immune response and eliminates PDAC cells by inducing ICD.

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Keywords {🔍}

cells, gem, cancer, cell, tumor, hifα, pancreatic, mice, treated, treatment, pdac, gempx, figure, hmgb, inhibition, death, icd, compared, immune, release, medium, immunogenic, significantly, response, dcs, exposure, atp, hours, combination, increased, crt, days, journal, lines, eifα, effect, panc, single, growth, antitumor, chemotherapy, expression, cbl, oncotarget, cytotoxic, control, lymphocytes, patients, conditioned, research,

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polarize interferon-gamma-producing cd8+ hypoxia-inducible factor 1alpha-mediated mouse anti-hmgb1 antibody rabbit anti-calreticulin antibody hypoxia-inducible factor-1alpha immune-deficient pdac-engrafted mice pdac-engrafted immune-competent mice specific pathogen-free conditions hypoxia-inducible factor-1α gem/px-478-treated cells showed hypoxia enhanced mdsc-mediated gem/px478-treated pdac cells oncolytic parvovirus h-1pv actin-bundling protein fascin tumor-specific cytotoxic t-cells bonferroni post-hoc test apc-anti-cd8 antibodies sided log-rank tests p16ink4a-deficient pancreatic cancers sided student t-tests ifn-γ elisa kit countering tumor-induced immunosuppression improve anti-cancer immunity dc/tumor cell ratio anti-tumor phagocytic function myeloid-derived suppressor cells hypoxia inducible factor-1 inaugural editorial dead cell antigens-mediated gem/px-478 significantly enhanced panc02-bearing immune-competent anti-hmgb1 antibody [47] reactive oxygen species-dependent kaplan-meier survival curved publication alerts subscribe treatment-induced immune response tumor single-cell suspension free publication gem/px-478-treated mice compared anti-crt antibody immune-deficient mice model hif-1α inhibitor 2-methoxyestradiol open-access journal dedicated including dc maturation/phagocytosis immune-competent mice models hypoxia-inducible factors tumor infiltrating t-lymphocytes tumor-bearing c57bl/6 mice current medicinal chemistry immune-deficient nude mice

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Article:
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         type:Organization
         name:Oncotarget
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            url:https://www.oncotarget.com/images/oncotarget-logo-square.png
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      dateModified:2015-03-08T22:43:47Z
      mainEntityOfPage:
         type:WebPage
         id:https://www.oncotarget.com/article/2948/text/
      headline:Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell
      articleSection:Research Papers
      sameAs:https://doi.org/10.18632/oncotarget.2948
      image:https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=viewFile&path%5B%5D=2948&path%5B%5D=5585&path%5B%5D=36120
      datePublished:2014-12-10T00:00:00Z
      author:
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            name:Zhao, Tiansuo
            type:Person
            name:Ren, He
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            name:Jia, Li
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            name:Chen, Jing
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            name:Gao, Song
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            name:Huang, Chongbiao
            type:Person
            name:Hao, Jihui
Organization:
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         url:https://www.oncotarget.com/images/oncotarget-logo-square.png
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WebPage:
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Person:
      name:Zhao, Tiansuo
      name:Ren, He
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      name:Xin, Wen
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      name:Wang, Xiuchao
      name:Gao, Song
      name:Qian, Dong
      name:Huang, Chongbiao
      name:Hao, Jihui

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