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wmh, university, pubmed, risk, association, article, supplementary, google, scholar, data, department, genetic, research, usa, stroke, loci, genomewide, center, cas, medical, central, significant, institute, medicine, volume, brain, health, matter, vascular, white, study, svd, traits, methods, disease, school, blood, analysis, variants, epidemiology, clinical, associations, small, dementia, vessel, pressure, gwas, hospital, leiden, nature,

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supplementary data files /roadmap/data/byfiletype/peaks/consolidated/narrowpeak/] nature portfolio supplementary data 1 supplementary data 3 supplementary data 4 supplementary data 5 supplementary data 6 supplementary data 7 supplementary data 8-10 supplementary data 11 supplementary data 12 supplementary data 13 supplementary data 14 supplementary data 15 supplementary data 16 supplementary data 17 supplementary data 19 supplementary data 20 supplementary data 21 supplementary data 22 supplementary data 2 privacy policy }}{\mathrm{cov}} + \varepsilon$$ reporting summary summary association data lu-chen weng & kerri advertising gene-expression data individual-level data social media traditional fixed-effects meta-analysis middle-age gwas data genome-wide association meta-analyses service ’hématologie biologique mr-mega transethnic meta-analysis personal data genome-wide summary statistics data protection data science detailed study-specific acknowledgements health services included data nature 506 nature 478 nature supplementary information marjo-riitta järvelin reprints

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• Perturbations of the cerebrovascular matrisome: a convergent mechanism in small vessel disease of the brain?
• Understanding the physiopathology behind axial and radial diffusivity changes-what do we know?

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         headline:Cerebral small vessel disease genomics and its implications across the lifespan
         description:White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime impact of SVD genetic risk. Mendelian randomization suggested causal association of increasing WMH-volume with stroke, Alzheimer-type dementia, and of increasing blood pressure (BP) with larger WMH-volume, notably also in persons without clinical hypertension. Transcriptome-wide colocalization analyses showed association of WMH-volume with expression of 39 genes, of which four encode known drug targets. Finally, we provide insight into BP-independent biological pathways underlying SVD and suggest potential for genetic stratification of high-risk individuals and for genetically-informed prioritization of drug targets for prevention trials. White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.
         datePublished:2020-12-08T00:00:00Z
         dateModified:2020-12-08T00:00:00Z
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         sameAs:https://doi.org/10.1038/s41467-020-19111-2
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            Genome-wide association studies
            White matter disease
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               name:Jerome I. Rotter
               url:http://orcid.org/0000-0001-7191-1723
               affiliation:
                     name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
                     address:
                        name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alexa S. Beiser
               affiliation:
                     name:Boston University School of Public Health
                     address:
                        name:Department of Biostatistics, Boston University School of Public Health, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Boston University and the NHLBI’s Framingham Heart Study
                     address:
                        name:Boston University and the NHLBI’s Framingham Heart Study, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Boston University School of Medicine
                     address:
                        name:Department of Neurology, Boston University School of Medicine, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Susana Muñoz Maniega
               affiliation:
                     name:University of Edinburgh
                     address:
                        name:Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Edinburgh
                     address:
                        name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marian Beekman
               url:http://orcid.org/0000-0003-0585-6206
               affiliation:
                     name:Leiden university Medical Center
                     address:
                        name:Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center, Leiden, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Julian Trollor
               url:http://orcid.org/0000-0002-7685-2977
               affiliation:
                     name:University of New South Wales
                     address:
                        name:Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
                        type:PostalAddress
                     type:Organization
                     name:University of New South Wales
                     address:
                        name:Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:David J. Stott
               affiliation:
                     name:Veterinary and Life Sciences, University of Glasgow
                     address:
                        name:Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Meike W. Vernooij
               affiliation:
                     name:Erasmus MC
                     address:
                        name:Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:Erasmus MC
                     address:
                        name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Katharina Wittfeld
               url:http://orcid.org/0000-0003-4383-5043
               affiliation:
                     name:German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald
                     address:
                        name:German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wiro J. Niessen
               affiliation:
                     name:Erasmus MC
                     address:
                        name:Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:Delft University of Technology
                     address:
                        name:Faculty of Applied Sciences, Delft University of Technology, Delft, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Aicha Soumaré
               url:http://orcid.org/0000-0002-0178-6506
               affiliation:
                     name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
                     address:
                        name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eric Boerwinkle
               affiliation:
                     name:University of Texas Health Science Center at Houston School of Public Health
                     address:
                        name:University of Texas Health Science Center at Houston School of Public Health, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Stephen Sidney
               affiliation:
                     name:Kaiser Permanente Division of Research
                     address:
                        name:Kaiser Permanente Division of Research, Oakland, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Stephen T. Turner
               affiliation:
                     name:Division of Nephrology and Hypertension, Mayo Clinic
                     address:
                        name:Division of Nephrology and Hypertension, Mayo Clinic, Rochester, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gail Davies
               affiliation:
                     name:Medical University of Graz
                     address:
                        name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
                        type:PostalAddress
                     type:Organization
                     name:University of Edinburgh
                     address:
                        name:Department of Psychology, University of Edinburgh, Edinburgh, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anbupalam Thalamuthu
               affiliation:
                     name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
                     address:
                        name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Uwe Völker
               url:http://orcid.org/0000-0002-5689-3448
               affiliation:
                     name:University Medicine Greifswald
                     address:
                        name:Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mark A. van Buchem
               affiliation:
                     name:University of Edinburgh
                     address:
                        name:Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:R. Nick Bryan
               affiliation:
                     name:The University of Texas at Austin Dell Medical School
                     address:
                        name:The University of Texas at Austin Dell Medical School, Austin, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Josée Dupuis
               url:http://orcid.org/0000-0003-2871-3603
               affiliation:
                     name:University of Texas Health Sciences Center
                     address:
                        name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
                        type:PostalAddress
                     type:Organization
                     name:Leiden University Medical Center
                     address:
                        name:Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mark E. Bastin
               affiliation:
                     name:Medical University of Graz
                     address:
                        name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
                        type:PostalAddress
                     type:Organization
                     name:University of Michigan
                     address:
                        name:Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:David Ames
               affiliation:
                     name:National Ageing Research Institute Royal Melbourne Hospital
                     address:
                        name:National Ageing Research Institute Royal Melbourne Hospital, Parkville, Australia
                        type:PostalAddress
                     type:Organization
                     name:University of Melbourne, St George’s Hospital
                     address:
                        name:Academic Unit for Psychiatry of Old Age, University of Melbourne, St George’s Hospital, Kew, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alexander Teumer
               url:http://orcid.org/0000-0002-8309-094X
               affiliation:
                     name:Erasmus MC
                     address:
                        name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:University Medicine Greifswald
                     address:
                        name:Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Philippe Amouyel
               url:http://orcid.org/0000-0001-9088-234X
               affiliation:
                     name:Inserm U1167
                     address:
                        name:Inserm U1167, Lille, France
                        type:PostalAddress
                     type:Organization
                     name:Pasteur Institute of Lille
                     address:
                        name:Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:John B. Kwok
               affiliation:
                     name:Brain and Mind Centre - The University of Sydney
                     address:
                        name:Brain and Mind Centre - The University of Sydney, Camperdown, Australia
                        type:PostalAddress
                     type:Organization
                     name:University of New South Wales
                     address:
                        name:School of Medical Sciences, University of New South Wales, Sydney, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Robin Bülow
               affiliation:
                     name:University Medicine Greifswald
                     address:
                        name:Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ian J. Deary
               affiliation:
                     name:Medical University of Graz
                     address:
                        name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
                        type:PostalAddress
                     type:Organization
                     name:University of Edinburgh
                     address:
                        name:Department of Psychology, University of Edinburgh, Edinburgh, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Peter R. Schofield
               url:http://orcid.org/0000-0003-2967-9662
               affiliation:
                     name:University of New South Wales
                     address:
                        name:School of Medical Sciences, University of New South Wales, Sydney, Australia
                        type:PostalAddress
                     type:Organization
                     name:Neuroscience Research Australia
                     address:
                        name:Neuroscience Research Australia, Randwick, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Henry Brodaty
               url:http://orcid.org/0000-0001-9487-6617
               affiliation:
                     name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
                     address:
                        name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
                        type:PostalAddress
                     type:Organization
                     name:University of New South Wales
                     address:
                        name:Dementia Centre for Research Collaboration, University of New South Wales, Sydney, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jiyang Jiang
               url:http://orcid.org/0000-0002-2147-6302
               affiliation:
                     name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
                     address:
                        name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yasuharu Tabara
               affiliation:
                     name:Kyoto University Graduate School of Medicine
                     address:
                        name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kazuya Setoh
               affiliation:
                     name:Kyoto University Graduate School of Medicine
                     address:
                        name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Susumu Miyamoto
               affiliation:
                     name:Kyoto University Graduate School of Medicine
                     address:
                        name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kazumichi Yoshida
               affiliation:
                     name:Kyoto University Graduate School of Medicine
                     address:
                        name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Manabu Nagata
               affiliation:
                     name:Kyoto University Graduate School of Medicine
                     address:
                        name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yoichiro Kamatani
               url:http://orcid.org/0000-0001-8748-5597
               affiliation:
                     name:Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku
                     address:
                        name:Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama City, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Fumihiko Matsuda
               affiliation:
                     name:Kyoto University Graduate School of Medicine
                     address:
                        name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bruce M. Psaty
               affiliation:
                     name:University of Washington
                     address:
                        name:Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, USA
                        type:PostalAddress
                     type:Organization
                     name:Kaiser Permanente Washington Health Research Institute
                     address:
                        name:Kaiser Permanente Washington Health Research Institute, Seattle, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:David A. Bennett
               affiliation:
                     name:Rush University Medical Center
                     address:
                        name:Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Philip L. De Jager
               url:http://orcid.org/0000-0002-8057-2505
               affiliation:
                     name:Columbia University Medical Center
                     address:
                        name:Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Broad Institute of MIT and Harvard
                     address:
                        name:Program in Population and Medical Genetics, Broad Institute of MIT and Harvard, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Thomas H. Mosley
               affiliation:
                     name:University of Mississippi Medical Center
                     address:
                        name:Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Perminder S. Sachdev
               url:http://orcid.org/0000-0002-9595-3220
               affiliation:
                     name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
                     address:
                        name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
                        type:PostalAddress
                     type:Organization
                     name:Neuropsychiatric Institute, Prince of Wales Hospital
                     address:
                        name:Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Reinhold Schmidt
               affiliation:
                     name:School of Public Health, University of Michigan
                     address:
                        name:Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Helen R. Warren
               url:http://orcid.org/0000-0003-0511-1386
               affiliation:
                     name:Queen Mary University of London
                     address:
                        name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
                        type:PostalAddress
                     type:Organization
                     name:Queen Mary University of London
                     address:
                        name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Evangelos Evangelou
               url:http://orcid.org/0000-0002-5488-2999
               affiliation:
                     name:School of Public Health, Imperial College London
                     address:
                        name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Ioannina Medical School
                     address:
                        name:Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
                        type:PostalAddress
                     type:Organization
               type:Person
               name:David-Alexandre Trégouët
               affiliation:
                     name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
                     address:
                        name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mohammad A. Ikram
               url:http://orcid.org/0000-0003-0372-8585
               affiliation:
                     name:Erasmus MC
                     address:
                        name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wei Wen
               url:http://orcid.org/0000-0003-2753-3870
               affiliation:
                     name:University of New South Wales
                     address:
                        name:Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Charles DeCarli
               affiliation:
                     name:University of California at Davis
                     address:
                        name:Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Velandai K. Srikanth
               affiliation:
                     name:University of Tasmania
                     address:
                        name:Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
                        type:PostalAddress
                     type:Organization
                     name:Monash University
                     address:
                        name:Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:J. Wouter Jukema
               url:http://orcid.org/0000-0002-3246-8359
               affiliation:
                     name:Leiden University Medical Center
                     address:
                        name:Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eline P. Slagboom
               url:http://orcid.org/0000-0002-2875-4723
               affiliation:
                     name:Leiden university Medical Center
                     address:
                        name:Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center, Leiden, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sharon L. R. Kardia
               affiliation:
                     name:School of Public Health, University of Michigan
                     address:
                        name:Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yukinori Okada
               url:http://orcid.org/0000-0002-0311-8472
               affiliation:
                     name:Osaka University Graduate School of Medicine
                     address:
                        name:Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan
                        type:PostalAddress
                     type:Organization
                     name:RIKEN Center for Integrative Medical Sciences, Tsurumi-ku
                     address:
                        name:Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama City, Japan
                        type:PostalAddress
                     type:Organization
                     name:Osaka University
                     address:
                        name:Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bernard Mazoyer
               url:http://orcid.org/0000-0003-0970-2837
               affiliation:
                     name:University of Bordeaux, IMN
                     address:
                        name:University of Bordeaux, IMN, Bordeaux, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Joanna M. Wardlaw
               url:http://orcid.org/0000-0002-9812-6642
               affiliation:
                     name:University of Edinburgh
                     address:
                        name:Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Edinburgh
                     address:
                        name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Edinburgh
                     address:
                        name:Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, UK
                        type:PostalAddress
                     type:Organization
                     name:MRC UK Dementia Research Institute at the University of Edinburgh
                     address:
                        name:MRC UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Paul A. Nyquist
               affiliation:
                     name:Johns Hopkins School of Medicine
                     address:
                        name:Department of Neurology, Johns Hopkins School of Medicine, Baltimone, USA
                        type:PostalAddress
                     type:Organization
                     name:Johns Hopkins School of Medicine
                     address:
                        name:General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Karen A. Mather
               affiliation:
                     name:University of New South Wales
                     address:
                        name:Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
                        type:PostalAddress
                     type:Organization
                     name:Neuroscience Research Australia
                     address:
                        name:Neuroscience Research Australia, Randwick, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hans J. Grabe
               url:http://orcid.org/0000-0003-3684-4208
               affiliation:
                     name:University Medicine Greifswald
                     address:
                        name:Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald
                     address:
                        name:German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Helena Schmidt
               affiliation:
                     name:Medical University of Graz
                     address:
                        name:Gottfried Schatz Research Center, Department of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Cornelia M. Van Duijn
               url:http://orcid.org/0000-0002-2374-9204
               affiliation:
                     name:University of Oxford
                     address:
                        name:Nuffield Department of Population Health, University of Oxford, Oxford, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Vilmundur Gudnason
               url:http://orcid.org/0000-0001-5696-0084
               affiliation:
                     name:Icelandic Heart Association
                     address:
                        name:Icelandic Heart Association, Kópavogur, Iceland
                        type:PostalAddress
                     type:Organization
                     name:University of Iceland, Faculty of Medicine
                     address:
                        name:University of Iceland, Faculty of Medicine, Reykjavík, Iceland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:William T. Longstreth
               affiliation:
                     name:University of Washington
                     address:
                        name:Departments of Neurology and Epidemiology, University of Washington, Seattle, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lenore J. Launer
               affiliation:
                     name:The National Institutes of Health
                     address:
                        name:Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
                     name:Intramural Research Program/National Institute on Aging/National Institutes of Health
                     address:
                        name:Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mark Lathrop
               affiliation:
                     name:University of McGill Genome Center
                     address:
                        name:University of McGill Genome Center, Montreal, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sudha Seshadri
               affiliation:
                     name:University of Texas Health Sciences Center
                     address:
                        name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
                        type:PostalAddress
                     type:Organization
                     name:Boston University and the NHLBI’s Framingham Heart Study
                     address:
                        name:Boston University and the NHLBI’s Framingham Heart Study, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Boston University School of Medicine
                     address:
                        name:Department of Neurology, Boston University School of Medicine, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christophe Tzourio
               affiliation:
                     name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
                     address:
                        name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
                        type:PostalAddress
                     type:Organization
                     name:Service d’information médicale
                     address:
                        name:CHU de Bordeaux, Pole de santé publique, Service d’information médicale, Bordeaux, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hieab H. Adams
               url:http://orcid.org/0000-0003-3687-2508
               affiliation:
                     name:Erasmus MC
                     address:
                        name:Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:Erasmus MC
                     address:
                        name:Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Paul M. Matthews
               url:http://orcid.org/0000-0002-1619-8328
               affiliation:
                     name:Imperial College London
                     address:
                        name:Department of Brain Sciences, Imperial College London, London, UK
                        type:PostalAddress
                     type:Organization
                     name:UK Dementia Research Institute
                     address:
                        name:UK Dementia Research Institute, London, UK
                        type:PostalAddress
                     type:Organization
                     name:Imperial College London
                     address:
                        name:Data Science Institute, Imperial College London, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Myriam Fornage
               url:http://orcid.org/0000-0003-0677-8158
               affiliation:
                     name:University of Texas Health Science Center at Houston McGovern Medical School
                     address:
                        name:University of Texas Health Science Center at Houston McGovern Medical School, Houston, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Stéphanie Debette
               url:http://orcid.org/0000-0001-8675-7968
               affiliation:
                     name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
                     address:
                        name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
                        type:PostalAddress
                     type:Organization
                     name:Boston University School of Medicine
                     address:
                        name:Department of Neurology, Boston University School of Medicine, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Department of Neurology, CHU de Bordeaux
                     address:
                        name:Department of Neurology, CHU de Bordeaux, Bordeaux, France
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Cerebral small vessel disease genomics and its implications across the lifespan
      description:White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime impact of SVD genetic risk. Mendelian randomization suggested causal association of increasing WMH-volume with stroke, Alzheimer-type dementia, and of increasing blood pressure (BP) with larger WMH-volume, notably also in persons without clinical hypertension. Transcriptome-wide colocalization analyses showed association of WMH-volume with expression of 39 genes, of which four encode known drug targets. Finally, we provide insight into BP-independent biological pathways underlying SVD and suggest potential for genetic stratification of high-risk individuals and for genetically-informed prioritization of drug targets for prevention trials. White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.
      datePublished:2020-12-08T00:00:00Z
      dateModified:2020-12-08T00:00:00Z
      pageStart:1
      pageEnd:18
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/s41467-020-19111-2
      keywords:
         Genome-wide association studies
         White matter disease
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19111-2/MediaObjects/41467_2020_19111_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19111-2/MediaObjects/41467_2020_19111_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19111-2/MediaObjects/41467_2020_19111_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19111-2/MediaObjects/41467_2020_19111_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-19111-2/MediaObjects/41467_2020_19111_Fig5_HTML.png
      isPartOf:
         name:Nature Communications
         issn:
            2041-1723
         volumeNumber:11
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Muralidharan Sargurupremraj
            affiliation:
                  name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
                  address:
                     name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hideaki Suzuki
            affiliation:
                  name:Tohoku University, 2-1, Seiryo, Aoba
                  address:
                     name:Tohoku Medical Megabank Organization, Tohoku University, 2-1, Seiryo, Aoba, Sendai, Japan
                     type:PostalAddress
                  type:Organization
                  name:Tohoku University Hospital, 1-1, Seiryo, Aoba
                  address:
                     name:Department of Cardiovascular Medicine, Tohoku University Hospital, 1-1, Seiryo, Aoba, Sendai, Japan
                     type:PostalAddress
                  type:Organization
                  name:Imperial College London
                  address:
                     name:Department of Brain Sciences, Imperial College London, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xueqiu Jian
            url:http://orcid.org/0000-0002-0313-6494
            affiliation:
                  name:University of Texas Health Science Center at Houston McGovern Medical School
                  address:
                     name:University of Texas Health Science Center at Houston McGovern Medical School, Houston, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Texas Health Sciences Center
                  address:
                     name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chloé Sarnowski
            url:http://orcid.org/0000-0002-6090-7099
            affiliation:
                  name:Boston University School of Public Health
                  address:
                     name:Department of Biostatistics, Boston University School of Public Health, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tavia E. Evans
            affiliation:
                  name:Erasmus MC
                  address:
                     name:Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Erasmus MC
                  address:
                     name:Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Joshua C. Bis
            affiliation:
                  name:University of Washington
                  address:
                     name:Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gudny Eiriksdottir
            affiliation:
                  name:Icelandic Heart Association
                  address:
                     name:Icelandic Heart Association, Kópavogur, Iceland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Saori Sakaue
            url:http://orcid.org/0000-0003-3618-9717
            affiliation:
                  name:Osaka University Graduate School of Medicine
                  address:
                     name:Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan
                     type:PostalAddress
                  type:Organization
                  name:RIKEN Center for Integrative Medical Sciences, Tsurumi-ku
                  address:
                     name:Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama City, Japan
                     type:PostalAddress
                  type:Organization
                  name:Graduate School of Medicine, the University of Tokyo
                  address:
                     name:Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Natalie Terzikhan
            affiliation:
                  name:Erasmus MC
                  address:
                     name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mohamad Habes
            affiliation:
                  name:University of Texas Health Sciences Center
                  address:
                     name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Pennsylvania
                  address:
                     name:Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:University Medicine Greifswald
                  address:
                     name:Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wei Zhao
            url:http://orcid.org/0000-0001-7388-0692
            affiliation:
                  name:School of Public Health, University of Michigan
                  address:
                     name:Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nicola J. Armstrong
            affiliation:
                  name:Murdoch University
                  address:
                     name:Mathematics and Statistics, Murdoch University, Murdoch, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Edith Hofer
            affiliation:
                  name:Medical University of Graz
                  address:
                     name:Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria
                     type:PostalAddress
                  type:Organization
                  name:Medical University of Graz
                  address:
                     name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lisa R. Yanek
            url:http://orcid.org/0000-0001-7117-1075
            affiliation:
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Saskia P. Hagenaars
            affiliation:
                  name:University of Edinburgh
                  address:
                     name:Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
                     type:PostalAddress
                  type:Organization
                  name:Psychology & Neuroscience, King’s College London
                  address:
                     name:Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rajan B. Kumar
            affiliation:
                  name:University of California at Davis
                  address:
                     name:Department of Public Health Sciences, University of California at Davis, Davis, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Erik B. van den Akker
            affiliation:
                  name:Leiden university Medical Center
                  address:
                     name:Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Delft University of Technology
                  address:
                     name:Pattern Recognition & Bioinformatics, Delft University of Technology, Delft, USA
                     type:PostalAddress
                  type:Organization
                  name:Leiden University Medical Centre
                  address:
                     name:Leiden Computational Biology Centre, Leiden University Medical Centre, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rebekah E. McWhirter
            url:http://orcid.org/0000-0002-9409-8074
            affiliation:
                  name:University of Tasmania
                  address:
                     name:Centre for Law and Genetics, Faculty of Law, University of Tasmania, Hobart, Australia
                     type:PostalAddress
                  type:Organization
                  name:University of Tasmania
                  address:
                     name:Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stella Trompet
            affiliation:
                  name:Leiden University Medical Center
                  address:
                     name:Department of Internal Medicine, section of gerontology and geriatrics, Leiden University Medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Leiden University Medical Center
                  address:
                     name:Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Aniket Mishra
            url:http://orcid.org/0000-0002-8141-1543
            affiliation:
                  name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
                  address:
                     name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yasaman Saba
            affiliation:
                  name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
                  address:
                     name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
                     type:PostalAddress
                  type:Organization
                  name:Medical University of Graz
                  address:
                     name:Gottfried Schatz Research Center, Department of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Claudia L. Satizabal
            url:http://orcid.org/0000-0002-1115-4430
            affiliation:
                  name:University of Texas Health Sciences Center
                  address:
                     name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
                     type:PostalAddress
                  type:Organization
                  name:Boston University and the NHLBI’s Framingham Heart Study
                  address:
                     name:Boston University and the NHLBI’s Framingham Heart Study, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Boston University School of Medicine
                  address:
                     name:Department of Neurology, Boston University School of Medicine, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gregory Beaudet
            affiliation:
                  name:University of Bordeaux, IMN
                  address:
                     name:University of Bordeaux, IMN, Bordeaux, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Laurent Petit
            affiliation:
                  name:University of Bordeaux, IMN
                  address:
                     name:University of Bordeaux, IMN, Bordeaux, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ami Tsuchida
            url:http://orcid.org/0000-0001-5160-6203
            affiliation:
                  name:University of Bordeaux, IMN
                  address:
                     name:University of Bordeaux, IMN, Bordeaux, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Laure Zago
            url:http://orcid.org/0000-0001-8235-2154
            affiliation:
                  name:University of Bordeaux, IMN
                  address:
                     name:University of Bordeaux, IMN, Bordeaux, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sabrina Schilling
            affiliation:
                  name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
                  address:
                     name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sigurdur Sigurdsson
            affiliation:
                  name:Icelandic Heart Association
                  address:
                     name:Icelandic Heart Association, Kópavogur, Iceland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rebecca F. Gottesman
            affiliation:
                  name:Johns Hopkins University School of Medicine
                  address:
                     name:Johns Hopkins University School of Medicine, Baltimore, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Cora E. Lewis
            affiliation:
                  name:University of Alabama at Birmingham School of Medicine
                  address:
                     name:University of Alabama at Birmingham School of Medicine, Birmingham, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Neelum T. Aggarwal
            affiliation:
                  name:Rush University Medical Center
                  address:
                     name:Department of Neurological Sciences, Rush University Medical Center, Chicago, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Oscar L. Lopez
            affiliation:
                  name:University of Pittsburgh
                  address:
                     name:Departments of Neurology and Psychiatry, University of Pittsburgh, Pittsburgh, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jennifer A. Smith
            url:http://orcid.org/0000-0002-3575-5468
            affiliation:
                  name:School of Public Health, University of Michigan
                  address:
                     name:Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Michigan
                  address:
                     name:Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Maria C. Valdés Hernández
            affiliation:
                  name:University of Edinburgh
                  address:
                     name:Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Edinburgh
                  address:
                     name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Edinburgh
                  address:
                     name:Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jeroen van der Grond
            affiliation:
                  name:Leiden University medical Center
                  address:
                     name:Department of Radiology, Leiden University medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Margaret J. Wright
            url:http://orcid.org/0000-0001-7133-4970
            affiliation:
                  name:The University of Queensland
                  address:
                     name:Queensland Brain Institute, The University of Queensland, St Lucia, Australia
                     type:PostalAddress
                  type:Organization
                  name:The University of Queensland
                  address:
                     name:Centre for Advanced Imaging, The University of Queensland, St Lucia, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Maria J. Knol
            url:http://orcid.org/0000-0002-3597-1531
            affiliation:
                  name:Erasmus MC
                  address:
                     name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marcus Dörr
            affiliation:
                  name:University Medicine Greifswald
                  address:
                     name:Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
                     type:PostalAddress
                  type:Organization
                  name:DZHK (German Center for Cardiovascular Research), partner site Greifswald
                  address:
                     name:DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Russell J. Thomson
            affiliation:
                  name:University of Tasmania
                  address:
                     name:Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
                     type:PostalAddress
                  type:Organization
                  name: Western Sydney University
                  address:
                     name:Centre for Research in Mathematics and Data Science, Western Sydney University, Penrith, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Constance Bordes
            affiliation:
                  name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
                  address:
                     name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Quentin Le Grand
            url:http://orcid.org/0000-0002-9299-0747
            affiliation:
                  name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
                  address:
                     name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marie-Gabrielle Duperron
            affiliation:
                  name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
                  address:
                     name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Albert V. Smith
            url:http://orcid.org/0000-0003-1942-5845
            affiliation:
                  name:Icelandic Heart Association
                  address:
                     name:Icelandic Heart Association, Kópavogur, Iceland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David S. Knopman
            affiliation:
                  name:Mayo Clinic
                  address:
                     name:Mayo Clinic, Rochester, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pamela J. Schreiner
            affiliation:
                  name:University of Minnesota School of Public Health
                  address:
                     name:University of Minnesota School of Public Health, Minneapolis, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Denis A. Evans
            affiliation:
                  name:Rush University Medical Center
                  address:
                     name:Department of Internal Medicine, Rush University Medical Center, Chicago, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jerome I. Rotter
            url:http://orcid.org/0000-0001-7191-1723
            affiliation:
                  name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
                  address:
                     name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alexa S. Beiser
            affiliation:
                  name:Boston University School of Public Health
                  address:
                     name:Department of Biostatistics, Boston University School of Public Health, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Boston University and the NHLBI’s Framingham Heart Study
                  address:
                     name:Boston University and the NHLBI’s Framingham Heart Study, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Boston University School of Medicine
                  address:
                     name:Department of Neurology, Boston University School of Medicine, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Susana Muñoz Maniega
            affiliation:
                  name:University of Edinburgh
                  address:
                     name:Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Edinburgh
                  address:
                     name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marian Beekman
            url:http://orcid.org/0000-0003-0585-6206
            affiliation:
                  name:Leiden university Medical Center
                  address:
                     name:Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Julian Trollor
            url:http://orcid.org/0000-0002-7685-2977
            affiliation:
                  name:University of New South Wales
                  address:
                     name:Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
                     type:PostalAddress
                  type:Organization
                  name:University of New South Wales
                  address:
                     name:Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David J. Stott
            affiliation:
                  name:Veterinary and Life Sciences, University of Glasgow
                  address:
                     name:Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Meike W. Vernooij
            affiliation:
                  name:Erasmus MC
                  address:
                     name:Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Erasmus MC
                  address:
                     name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Katharina Wittfeld
            url:http://orcid.org/0000-0003-4383-5043
            affiliation:
                  name:German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald
                  address:
                     name:German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wiro J. Niessen
            affiliation:
                  name:Erasmus MC
                  address:
                     name:Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Delft University of Technology
                  address:
                     name:Faculty of Applied Sciences, Delft University of Technology, Delft, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Aicha Soumaré
            url:http://orcid.org/0000-0002-0178-6506
            affiliation:
                  name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
                  address:
                     name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eric Boerwinkle
            affiliation:
                  name:University of Texas Health Science Center at Houston School of Public Health
                  address:
                     name:University of Texas Health Science Center at Houston School of Public Health, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stephen Sidney
            affiliation:
                  name:Kaiser Permanente Division of Research
                  address:
                     name:Kaiser Permanente Division of Research, Oakland, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stephen T. Turner
            affiliation:
                  name:Division of Nephrology and Hypertension, Mayo Clinic
                  address:
                     name:Division of Nephrology and Hypertension, Mayo Clinic, Rochester, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gail Davies
            affiliation:
                  name:Medical University of Graz
                  address:
                     name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
                     type:PostalAddress
                  type:Organization
                  name:University of Edinburgh
                  address:
                     name:Department of Psychology, University of Edinburgh, Edinburgh, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anbupalam Thalamuthu
            affiliation:
                  name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
                  address:
                     name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Uwe Völker
            url:http://orcid.org/0000-0002-5689-3448
            affiliation:
                  name:University Medicine Greifswald
                  address:
                     name:Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mark A. van Buchem
            affiliation:
                  name:University of Edinburgh
                  address:
                     name:Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:R. Nick Bryan
            affiliation:
                  name:The University of Texas at Austin Dell Medical School
                  address:
                     name:The University of Texas at Austin Dell Medical School, Austin, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Josée Dupuis
            url:http://orcid.org/0000-0003-2871-3603
            affiliation:
                  name:University of Texas Health Sciences Center
                  address:
                     name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
                     type:PostalAddress
                  type:Organization
                  name:Leiden University Medical Center
                  address:
                     name:Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mark E. Bastin
            affiliation:
                  name:Medical University of Graz
                  address:
                     name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
                     type:PostalAddress
                  type:Organization
                  name:University of Michigan
                  address:
                     name:Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David Ames
            affiliation:
                  name:National Ageing Research Institute Royal Melbourne Hospital
                  address:
                     name:National Ageing Research Institute Royal Melbourne Hospital, Parkville, Australia
                     type:PostalAddress
                  type:Organization
                  name:University of Melbourne, St George’s Hospital
                  address:
                     name:Academic Unit for Psychiatry of Old Age, University of Melbourne, St George’s Hospital, Kew, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alexander Teumer
            url:http://orcid.org/0000-0002-8309-094X
            affiliation:
                  name:Erasmus MC
                  address:
                     name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:University Medicine Greifswald
                  address:
                     name:Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Philippe Amouyel
            url:http://orcid.org/0000-0001-9088-234X
            affiliation:
                  name:Inserm U1167
                  address:
                     name:Inserm U1167, Lille, France
                     type:PostalAddress
                  type:Organization
                  name:Pasteur Institute of Lille
                  address:
                     name:Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John B. Kwok
            affiliation:
                  name:Brain and Mind Centre - The University of Sydney
                  address:
                     name:Brain and Mind Centre - The University of Sydney, Camperdown, Australia
                     type:PostalAddress
                  type:Organization
                  name:University of New South Wales
                  address:
                     name:School of Medical Sciences, University of New South Wales, Sydney, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Robin Bülow
            affiliation:
                  name:University Medicine Greifswald
                  address:
                     name:Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ian J. Deary
            affiliation:
                  name:Medical University of Graz
                  address:
                     name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
                     type:PostalAddress
                  type:Organization
                  name:University of Edinburgh
                  address:
                     name:Department of Psychology, University of Edinburgh, Edinburgh, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Peter R. Schofield
            url:http://orcid.org/0000-0003-2967-9662
            affiliation:
                  name:University of New South Wales
                  address:
                     name:School of Medical Sciences, University of New South Wales, Sydney, Australia
                     type:PostalAddress
                  type:Organization
                  name:Neuroscience Research Australia
                  address:
                     name:Neuroscience Research Australia, Randwick, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Henry Brodaty
            url:http://orcid.org/0000-0001-9487-6617
            affiliation:
                  name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
                  address:
                     name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
                     type:PostalAddress
                  type:Organization
                  name:University of New South Wales
                  address:
                     name:Dementia Centre for Research Collaboration, University of New South Wales, Sydney, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jiyang Jiang
            url:http://orcid.org/0000-0002-2147-6302
            affiliation:
                  name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
                  address:
                     name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yasuharu Tabara
            affiliation:
                  name:Kyoto University Graduate School of Medicine
                  address:
                     name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kazuya Setoh
            affiliation:
                  name:Kyoto University Graduate School of Medicine
                  address:
                     name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Susumu Miyamoto
            affiliation:
                  name:Kyoto University Graduate School of Medicine
                  address:
                     name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kazumichi Yoshida
            affiliation:
                  name:Kyoto University Graduate School of Medicine
                  address:
                     name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Manabu Nagata
            affiliation:
                  name:Kyoto University Graduate School of Medicine
                  address:
                     name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yoichiro Kamatani
            url:http://orcid.org/0000-0001-8748-5597
            affiliation:
                  name:Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku
                  address:
                     name:Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama City, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Fumihiko Matsuda
            affiliation:
                  name:Kyoto University Graduate School of Medicine
                  address:
                     name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bruce M. Psaty
            affiliation:
                  name:University of Washington
                  address:
                     name:Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, USA
                     type:PostalAddress
                  type:Organization
                  name:Kaiser Permanente Washington Health Research Institute
                  address:
                     name:Kaiser Permanente Washington Health Research Institute, Seattle, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David A. Bennett
            affiliation:
                  name:Rush University Medical Center
                  address:
                     name:Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Philip L. De Jager
            url:http://orcid.org/0000-0002-8057-2505
            affiliation:
                  name:Columbia University Medical Center
                  address:
                     name:Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Broad Institute of MIT and Harvard
                  address:
                     name:Program in Population and Medical Genetics, Broad Institute of MIT and Harvard, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thomas H. Mosley
            affiliation:
                  name:University of Mississippi Medical Center
                  address:
                     name:Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Perminder S. Sachdev
            url:http://orcid.org/0000-0002-9595-3220
            affiliation:
                  name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
                  address:
                     name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
                     type:PostalAddress
                  type:Organization
                  name:Neuropsychiatric Institute, Prince of Wales Hospital
                  address:
                     name:Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Reinhold Schmidt
            affiliation:
                  name:School of Public Health, University of Michigan
                  address:
                     name:Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Helen R. Warren
            url:http://orcid.org/0000-0003-0511-1386
            affiliation:
                  name:Queen Mary University of London
                  address:
                     name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
                     type:PostalAddress
                  type:Organization
                  name:Queen Mary University of London
                  address:
                     name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Evangelos Evangelou
            url:http://orcid.org/0000-0002-5488-2999
            affiliation:
                  name:School of Public Health, Imperial College London
                  address:
                     name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Ioannina Medical School
                  address:
                     name:Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David-Alexandre Trégouët
            affiliation:
                  name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
                  address:
                     name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mohammad A. Ikram
            url:http://orcid.org/0000-0003-0372-8585
            affiliation:
                  name:Erasmus MC
                  address:
                     name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wei Wen
            url:http://orcid.org/0000-0003-2753-3870
            affiliation:
                  name:University of New South Wales
                  address:
                     name:Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Charles DeCarli
            affiliation:
                  name:University of California at Davis
                  address:
                     name:Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Velandai K. Srikanth
            affiliation:
                  name:University of Tasmania
                  address:
                     name:Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
                     type:PostalAddress
                  type:Organization
                  name:Monash University
                  address:
                     name:Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:J. Wouter Jukema
            url:http://orcid.org/0000-0002-3246-8359
            affiliation:
                  name:Leiden University Medical Center
                  address:
                     name:Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eline P. Slagboom
            url:http://orcid.org/0000-0002-2875-4723
            affiliation:
                  name:Leiden university Medical Center
                  address:
                     name:Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sharon L. R. Kardia
            affiliation:
                  name:School of Public Health, University of Michigan
                  address:
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      address:
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      address:
         name:Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, UK
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         name:Kaiser Permanente Washington Health Research Institute, Seattle, USA
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         name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
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      name:Erasmus MC
      address:
         name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
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      address:
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         name:German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany
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      address:
         name:Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, USA
         type:PostalAddress
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      address:
         name:University of McGill Genome Center, Montreal, Canada
         type:PostalAddress
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      address:
         name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
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         name:Department of Brain Sciences, Imperial College London, London, UK
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         name:UK Dementia Research Institute, London, UK
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         name:Data Science Institute, Imperial College London, London, UK
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         name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
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      name:Wei Zhao
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               name:Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
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               type:PostalAddress
            type:Organization
      name:Claudia L. Satizabal
      url:http://orcid.org/0000-0002-1115-4430
      affiliation:
            name:University of Texas Health Sciences Center
            address:
               name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
               type:PostalAddress
            type:Organization
            name:Boston University and the NHLBI’s Framingham Heart Study
            address:
               name:Boston University and the NHLBI’s Framingham Heart Study, Boston, USA
               type:PostalAddress
            type:Organization
            name:Boston University School of Medicine
            address:
               name:Department of Neurology, Boston University School of Medicine, Boston, USA
               type:PostalAddress
            type:Organization
      name:Gregory Beaudet
      affiliation:
            name:University of Bordeaux, IMN
            address:
               name:University of Bordeaux, IMN, Bordeaux, France
               type:PostalAddress
            type:Organization
      name:Laurent Petit
      affiliation:
            name:University of Bordeaux, IMN
            address:
               name:University of Bordeaux, IMN, Bordeaux, France
               type:PostalAddress
            type:Organization
      name:Ami Tsuchida
      url:http://orcid.org/0000-0001-5160-6203
      affiliation:
            name:University of Bordeaux, IMN
            address:
               name:University of Bordeaux, IMN, Bordeaux, France
               type:PostalAddress
            type:Organization
      name:Laure Zago
      url:http://orcid.org/0000-0001-8235-2154
      affiliation:
            name:University of Bordeaux, IMN
            address:
               name:University of Bordeaux, IMN, Bordeaux, France
               type:PostalAddress
            type:Organization
      name:Sabrina Schilling
      affiliation:
            name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
            address:
               name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
               type:PostalAddress
            type:Organization
      name:Sigurdur Sigurdsson
      affiliation:
            name:Icelandic Heart Association
            address:
               name:Icelandic Heart Association, Kópavogur, Iceland
               type:PostalAddress
            type:Organization
      name:Rebecca F. Gottesman
      affiliation:
            name:Johns Hopkins University School of Medicine
            address:
               name:Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Cora E. Lewis
      affiliation:
            name:University of Alabama at Birmingham School of Medicine
            address:
               name:University of Alabama at Birmingham School of Medicine, Birmingham, USA
               type:PostalAddress
            type:Organization
      name:Neelum T. Aggarwal
      affiliation:
            name:Rush University Medical Center
            address:
               name:Department of Neurological Sciences, Rush University Medical Center, Chicago, USA
               type:PostalAddress
            type:Organization
      name:Oscar L. Lopez
      affiliation:
            name:University of Pittsburgh
            address:
               name:Departments of Neurology and Psychiatry, University of Pittsburgh, Pittsburgh, USA
               type:PostalAddress
            type:Organization
      name:Jennifer A. Smith
      url:http://orcid.org/0000-0002-3575-5468
      affiliation:
            name:School of Public Health, University of Michigan
            address:
               name:Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
               type:PostalAddress
            type:Organization
            name:University of Michigan
            address:
               name:Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, USA
               type:PostalAddress
            type:Organization
      name:Maria C. Valdés Hernández
      affiliation:
            name:University of Edinburgh
            address:
               name:Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
            name:University of Edinburgh
            address:
               name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
            name:University of Edinburgh
            address:
               name:Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
      name:Jeroen van der Grond
      affiliation:
            name:Leiden University medical Center
            address:
               name:Department of Radiology, Leiden University medical Center, Leiden, The Netherlands
               type:PostalAddress
            type:Organization
      name:Margaret J. Wright
      url:http://orcid.org/0000-0001-7133-4970
      affiliation:
            name:The University of Queensland
            address:
               name:Queensland Brain Institute, The University of Queensland, St Lucia, Australia
               type:PostalAddress
            type:Organization
            name:The University of Queensland
            address:
               name:Centre for Advanced Imaging, The University of Queensland, St Lucia, Australia
               type:PostalAddress
            type:Organization
      name:Maria J. Knol
      url:http://orcid.org/0000-0002-3597-1531
      affiliation:
            name:Erasmus MC
            address:
               name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Marcus Dörr
      affiliation:
            name:University Medicine Greifswald
            address:
               name:Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
               type:PostalAddress
            type:Organization
            name:DZHK (German Center for Cardiovascular Research), partner site Greifswald
            address:
               name:DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany
               type:PostalAddress
            type:Organization
      name:Russell J. Thomson
      affiliation:
            name:University of Tasmania
            address:
               name:Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
               type:PostalAddress
            type:Organization
            name: Western Sydney University
            address:
               name:Centre for Research in Mathematics and Data Science, Western Sydney University, Penrith, Australia
               type:PostalAddress
            type:Organization
      name:Constance Bordes
      affiliation:
            name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
            address:
               name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
               type:PostalAddress
            type:Organization
      name:Quentin Le Grand
      url:http://orcid.org/0000-0002-9299-0747
      affiliation:
            name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
            address:
               name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
               type:PostalAddress
            type:Organization
      name:Marie-Gabrielle Duperron
      affiliation:
            name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
            address:
               name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
               type:PostalAddress
            type:Organization
      name:Albert V. Smith
      url:http://orcid.org/0000-0003-1942-5845
      affiliation:
            name:Icelandic Heart Association
            address:
               name:Icelandic Heart Association, Kópavogur, Iceland
               type:PostalAddress
            type:Organization
      name:David S. Knopman
      affiliation:
            name:Mayo Clinic
            address:
               name:Mayo Clinic, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Pamela J. Schreiner
      affiliation:
            name:University of Minnesota School of Public Health
            address:
               name:University of Minnesota School of Public Health, Minneapolis, USA
               type:PostalAddress
            type:Organization
      name:Denis A. Evans
      affiliation:
            name:Rush University Medical Center
            address:
               name:Department of Internal Medicine, Rush University Medical Center, Chicago, USA
               type:PostalAddress
            type:Organization
      name:Jerome I. Rotter
      url:http://orcid.org/0000-0001-7191-1723
      affiliation:
            name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
            address:
               name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
               type:PostalAddress
            type:Organization
      name:Alexa S. Beiser
      affiliation:
            name:Boston University School of Public Health
            address:
               name:Department of Biostatistics, Boston University School of Public Health, Boston, USA
               type:PostalAddress
            type:Organization
            name:Boston University and the NHLBI’s Framingham Heart Study
            address:
               name:Boston University and the NHLBI’s Framingham Heart Study, Boston, USA
               type:PostalAddress
            type:Organization
            name:Boston University School of Medicine
            address:
               name:Department of Neurology, Boston University School of Medicine, Boston, USA
               type:PostalAddress
            type:Organization
      name:Susana Muñoz Maniega
      affiliation:
            name:University of Edinburgh
            address:
               name:Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
            name:University of Edinburgh
            address:
               name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
      name:Marian Beekman
      url:http://orcid.org/0000-0003-0585-6206
      affiliation:
            name:Leiden university Medical Center
            address:
               name:Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center, Leiden, The Netherlands
               type:PostalAddress
            type:Organization
      name:Julian Trollor
      url:http://orcid.org/0000-0002-7685-2977
      affiliation:
            name:University of New South Wales
            address:
               name:Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
               type:PostalAddress
            type:Organization
            name:University of New South Wales
            address:
               name:Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, Australia
               type:PostalAddress
            type:Organization
      name:David J. Stott
      affiliation:
            name:Veterinary and Life Sciences, University of Glasgow
            address:
               name:Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
               type:PostalAddress
            type:Organization
      name:Meike W. Vernooij
      affiliation:
            name:Erasmus MC
            address:
               name:Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:Erasmus MC
            address:
               name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Katharina Wittfeld
      url:http://orcid.org/0000-0003-4383-5043
      affiliation:
            name:German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald
            address:
               name:German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany
               type:PostalAddress
            type:Organization
      name:Wiro J. Niessen
      affiliation:
            name:Erasmus MC
            address:
               name:Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:Delft University of Technology
            address:
               name:Faculty of Applied Sciences, Delft University of Technology, Delft, USA
               type:PostalAddress
            type:Organization
      name:Aicha Soumaré
      url:http://orcid.org/0000-0002-0178-6506
      affiliation:
            name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
            address:
               name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
               type:PostalAddress
            type:Organization
      name:Eric Boerwinkle
      affiliation:
            name:University of Texas Health Science Center at Houston School of Public Health
            address:
               name:University of Texas Health Science Center at Houston School of Public Health, Houston, USA
               type:PostalAddress
            type:Organization
      name:Stephen Sidney
      affiliation:
            name:Kaiser Permanente Division of Research
            address:
               name:Kaiser Permanente Division of Research, Oakland, USA
               type:PostalAddress
            type:Organization
      name:Stephen T. Turner
      affiliation:
            name:Division of Nephrology and Hypertension, Mayo Clinic
            address:
               name:Division of Nephrology and Hypertension, Mayo Clinic, Rochester, USA
               type:PostalAddress
            type:Organization
      name:Gail Davies
      affiliation:
            name:Medical University of Graz
            address:
               name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
               type:PostalAddress
            type:Organization
            name:University of Edinburgh
            address:
               name:Department of Psychology, University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
      name:Anbupalam Thalamuthu
      affiliation:
            name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
            address:
               name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
               type:PostalAddress
            type:Organization
      name:Uwe Völker
      url:http://orcid.org/0000-0002-5689-3448
      affiliation:
            name:University Medicine Greifswald
            address:
               name:Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
               type:PostalAddress
            type:Organization
      name:Mark A. van Buchem
      affiliation:
            name:University of Edinburgh
            address:
               name:Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
      name:R. Nick Bryan
      affiliation:
            name:The University of Texas at Austin Dell Medical School
            address:
               name:The University of Texas at Austin Dell Medical School, Austin, USA
               type:PostalAddress
            type:Organization
      name:Josée Dupuis
      url:http://orcid.org/0000-0003-2871-3603
      affiliation:
            name:University of Texas Health Sciences Center
            address:
               name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
               type:PostalAddress
            type:Organization
            name:Leiden University Medical Center
            address:
               name:Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
               type:PostalAddress
            type:Organization
      name:Mark E. Bastin
      affiliation:
            name:Medical University of Graz
            address:
               name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
               type:PostalAddress
            type:Organization
            name:University of Michigan
            address:
               name:Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, USA
               type:PostalAddress
            type:Organization
      name:David Ames
      affiliation:
            name:National Ageing Research Institute Royal Melbourne Hospital
            address:
               name:National Ageing Research Institute Royal Melbourne Hospital, Parkville, Australia
               type:PostalAddress
            type:Organization
            name:University of Melbourne, St George’s Hospital
            address:
               name:Academic Unit for Psychiatry of Old Age, University of Melbourne, St George’s Hospital, Kew, Australia
               type:PostalAddress
            type:Organization
      name:Alexander Teumer
      url:http://orcid.org/0000-0002-8309-094X
      affiliation:
            name:Erasmus MC
            address:
               name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:University Medicine Greifswald
            address:
               name:Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
               type:PostalAddress
            type:Organization
      name:Philippe Amouyel
      url:http://orcid.org/0000-0001-9088-234X
      affiliation:
            name:Inserm U1167
            address:
               name:Inserm U1167, Lille, France
               type:PostalAddress
            type:Organization
            name:Pasteur Institute of Lille
            address:
               name:Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France
               type:PostalAddress
            type:Organization
      name:John B. Kwok
      affiliation:
            name:Brain and Mind Centre - The University of Sydney
            address:
               name:Brain and Mind Centre - The University of Sydney, Camperdown, Australia
               type:PostalAddress
            type:Organization
            name:University of New South Wales
            address:
               name:School of Medical Sciences, University of New South Wales, Sydney, Australia
               type:PostalAddress
            type:Organization
      name:Robin Bülow
      affiliation:
            name:University Medicine Greifswald
            address:
               name:Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
               type:PostalAddress
            type:Organization
      name:Ian J. Deary
      affiliation:
            name:Medical University of Graz
            address:
               name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
               type:PostalAddress
            type:Organization
            name:University of Edinburgh
            address:
               name:Department of Psychology, University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
      name:Peter R. Schofield
      url:http://orcid.org/0000-0003-2967-9662
      affiliation:
            name:University of New South Wales
            address:
               name:School of Medical Sciences, University of New South Wales, Sydney, Australia
               type:PostalAddress
            type:Organization
            name:Neuroscience Research Australia
            address:
               name:Neuroscience Research Australia, Randwick, Australia
               type:PostalAddress
            type:Organization
      name:Henry Brodaty
      url:http://orcid.org/0000-0001-9487-6617
      affiliation:
            name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
            address:
               name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
               type:PostalAddress
            type:Organization
            name:University of New South Wales
            address:
               name:Dementia Centre for Research Collaboration, University of New South Wales, Sydney, Australia
               type:PostalAddress
            type:Organization
      name:Jiyang Jiang
      url:http://orcid.org/0000-0002-2147-6302
      affiliation:
            name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
            address:
               name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
               type:PostalAddress
            type:Organization
      name:Yasuharu Tabara
      affiliation:
            name:Kyoto University Graduate School of Medicine
            address:
               name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Kazuya Setoh
      affiliation:
            name:Kyoto University Graduate School of Medicine
            address:
               name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Susumu Miyamoto
      affiliation:
            name:Kyoto University Graduate School of Medicine
            address:
               name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Kazumichi Yoshida
      affiliation:
            name:Kyoto University Graduate School of Medicine
            address:
               name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Manabu Nagata
      affiliation:
            name:Kyoto University Graduate School of Medicine
            address:
               name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Yoichiro Kamatani
      url:http://orcid.org/0000-0001-8748-5597
      affiliation:
            name:Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku
            address:
               name:Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama City, Japan
               type:PostalAddress
            type:Organization
      name:Fumihiko Matsuda
      affiliation:
            name:Kyoto University Graduate School of Medicine
            address:
               name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
               type:PostalAddress
            type:Organization
      name:Bruce M. Psaty
      affiliation:
            name:University of Washington
            address:
               name:Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, USA
               type:PostalAddress
            type:Organization
            name:Kaiser Permanente Washington Health Research Institute
            address:
               name:Kaiser Permanente Washington Health Research Institute, Seattle, USA
               type:PostalAddress
            type:Organization
      name:David A. Bennett
      affiliation:
            name:Rush University Medical Center
            address:
               name:Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, USA
               type:PostalAddress
            type:Organization
      name:Philip L. De Jager
      url:http://orcid.org/0000-0002-8057-2505
      affiliation:
            name:Columbia University Medical Center
            address:
               name:Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, USA
               type:PostalAddress
            type:Organization
            name:Broad Institute of MIT and Harvard
            address:
               name:Program in Population and Medical Genetics, Broad Institute of MIT and Harvard, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Thomas H. Mosley
      affiliation:
            name:University of Mississippi Medical Center
            address:
               name:Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, USA
               type:PostalAddress
            type:Organization
      name:Perminder S. Sachdev
      url:http://orcid.org/0000-0002-9595-3220
      affiliation:
            name:Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center
            address:
               name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
               type:PostalAddress
            type:Organization
            name:Neuropsychiatric Institute, Prince of Wales Hospital
            address:
               name:Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
               type:PostalAddress
            type:Organization
      name:Reinhold Schmidt
      affiliation:
            name:School of Public Health, University of Michigan
            address:
               name:Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
               type:PostalAddress
            type:Organization
      name:Helen R. Warren
      url:http://orcid.org/0000-0003-0511-1386
      affiliation:
            name:Queen Mary University of London
            address:
               name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
               type:PostalAddress
            type:Organization
            name:Queen Mary University of London
            address:
               name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
               type:PostalAddress
            type:Organization
      name:Evangelos Evangelou
      url:http://orcid.org/0000-0002-5488-2999
      affiliation:
            name:School of Public Health, Imperial College London
            address:
               name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
            name:University of Ioannina Medical School
            address:
               name:Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
               type:PostalAddress
            type:Organization
      name:David-Alexandre Trégouët
      affiliation:
            name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
            address:
               name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
               type:PostalAddress
            type:Organization
      name:Mohammad A. Ikram
      url:http://orcid.org/0000-0003-0372-8585
      affiliation:
            name:Erasmus MC
            address:
               name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Wei Wen
      url:http://orcid.org/0000-0003-2753-3870
      affiliation:
            name:University of New South Wales
            address:
               name:Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
               type:PostalAddress
            type:Organization
      name:Charles DeCarli
      affiliation:
            name:University of California at Davis
            address:
               name:Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, USA
               type:PostalAddress
            type:Organization
      name:Velandai K. Srikanth
      affiliation:
            name:University of Tasmania
            address:
               name:Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
               type:PostalAddress
            type:Organization
            name:Monash University
            address:
               name:Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia
               type:PostalAddress
            type:Organization
      name:J. Wouter Jukema
      url:http://orcid.org/0000-0002-3246-8359
      affiliation:
            name:Leiden University Medical Center
            address:
               name:Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
               type:PostalAddress
            type:Organization
      name:Eline P. Slagboom
      url:http://orcid.org/0000-0002-2875-4723
      affiliation:
            name:Leiden university Medical Center
            address:
               name:Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center, Leiden, The Netherlands
               type:PostalAddress
            type:Organization
      name:Sharon L. R. Kardia
      affiliation:
            name:School of Public Health, University of Michigan
            address:
               name:Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
               type:PostalAddress
            type:Organization
      name:Yukinori Okada
      url:http://orcid.org/0000-0002-0311-8472
      affiliation:
            name:Osaka University Graduate School of Medicine
            address:
               name:Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan
               type:PostalAddress
            type:Organization
            name:RIKEN Center for Integrative Medical Sciences, Tsurumi-ku
            address:
               name:Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama City, Japan
               type:PostalAddress
            type:Organization
            name:Osaka University
            address:
               name:Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan
               type:PostalAddress
            type:Organization
      name:Bernard Mazoyer
      url:http://orcid.org/0000-0003-0970-2837
      affiliation:
            name:University of Bordeaux, IMN
            address:
               name:University of Bordeaux, IMN, Bordeaux, France
               type:PostalAddress
            type:Organization
      name:Joanna M. Wardlaw
      url:http://orcid.org/0000-0002-9812-6642
      affiliation:
            name:University of Edinburgh
            address:
               name:Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
            name:University of Edinburgh
            address:
               name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
            name:University of Edinburgh
            address:
               name:Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
            name:MRC UK Dementia Research Institute at the University of Edinburgh
            address:
               name:MRC UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
               type:PostalAddress
            type:Organization
      name:Paul A. Nyquist
      affiliation:
            name:Johns Hopkins School of Medicine
            address:
               name:Department of Neurology, Johns Hopkins School of Medicine, Baltimone, USA
               type:PostalAddress
            type:Organization
            name:Johns Hopkins School of Medicine
            address:
               name:General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Karen A. Mather
      affiliation:
            name:University of New South Wales
            address:
               name:Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
               type:PostalAddress
            type:Organization
            name:Neuroscience Research Australia
            address:
               name:Neuroscience Research Australia, Randwick, Australia
               type:PostalAddress
            type:Organization
      name:Hans J. Grabe
      url:http://orcid.org/0000-0003-3684-4208
      affiliation:
            name:University Medicine Greifswald
            address:
               name:Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
               type:PostalAddress
            type:Organization
            name:German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald
            address:
               name:German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany
               type:PostalAddress
            type:Organization
      name:Helena Schmidt
      affiliation:
            name:Medical University of Graz
            address:
               name:Gottfried Schatz Research Center, Department of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
               type:PostalAddress
            type:Organization
      name:Cornelia M. Van Duijn
      url:http://orcid.org/0000-0002-2374-9204
      affiliation:
            name:University of Oxford
            address:
               name:Nuffield Department of Population Health, University of Oxford, Oxford, UK
               type:PostalAddress
            type:Organization
      name:Vilmundur Gudnason
      url:http://orcid.org/0000-0001-5696-0084
      affiliation:
            name:Icelandic Heart Association
            address:
               name:Icelandic Heart Association, Kópavogur, Iceland
               type:PostalAddress
            type:Organization
            name:University of Iceland, Faculty of Medicine
            address:
               name:University of Iceland, Faculty of Medicine, Reykjavík, Iceland
               type:PostalAddress
            type:Organization
      name:William T. Longstreth
      affiliation:
            name:University of Washington
            address:
               name:Departments of Neurology and Epidemiology, University of Washington, Seattle, USA
               type:PostalAddress
            type:Organization
      name:Lenore J. Launer
      affiliation:
            name:The National Institutes of Health
            address:
               name:Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
            name:Intramural Research Program/National Institute on Aging/National Institutes of Health
            address:
               name:Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      name:Mark Lathrop
      affiliation:
            name:University of McGill Genome Center
            address:
               name:University of McGill Genome Center, Montreal, Canada
               type:PostalAddress
            type:Organization
      name:Sudha Seshadri
      affiliation:
            name:University of Texas Health Sciences Center
            address:
               name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
               type:PostalAddress
            type:Organization
            name:Boston University and the NHLBI’s Framingham Heart Study
            address:
               name:Boston University and the NHLBI’s Framingham Heart Study, Boston, USA
               type:PostalAddress
            type:Organization
            name:Boston University School of Medicine
            address:
               name:Department of Neurology, Boston University School of Medicine, Boston, USA
               type:PostalAddress
            type:Organization
      name:Christophe Tzourio
      affiliation:
            name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
            address:
               name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
               type:PostalAddress
            type:Organization
            name:Service d’information médicale
            address:
               name:CHU de Bordeaux, Pole de santé publique, Service d’information médicale, Bordeaux, France
               type:PostalAddress
            type:Organization
      name:Hieab H. Adams
      url:http://orcid.org/0000-0003-3687-2508
      affiliation:
            name:Erasmus MC
            address:
               name:Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
            name:Erasmus MC
            address:
               name:Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Paul M. Matthews
      url:http://orcid.org/0000-0002-1619-8328
      affiliation:
            name:Imperial College London
            address:
               name:Department of Brain Sciences, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
            name:UK Dementia Research Institute
            address:
               name:UK Dementia Research Institute, London, UK
               type:PostalAddress
            type:Organization
            name:Imperial College London
            address:
               name:Data Science Institute, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      name:Myriam Fornage
      url:http://orcid.org/0000-0003-0677-8158
      affiliation:
            name:University of Texas Health Science Center at Houston McGovern Medical School
            address:
               name:University of Texas Health Science Center at Houston McGovern Medical School, Houston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Stéphanie Debette
      url:http://orcid.org/0000-0001-8675-7968
      affiliation:
            name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center
            address:
               name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
               type:PostalAddress
            type:Organization
            name:Boston University School of Medicine
            address:
               name:Department of Neurology, Boston University School of Medicine, Boston, USA
               type:PostalAddress
            type:Organization
            name:Department of Neurology, CHU de Bordeaux
            address:
               name:Department of Neurology, CHU de Bordeaux, Bordeaux, France
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
      name:Tohoku Medical Megabank Organization, Tohoku University, 2-1, Seiryo, Aoba, Sendai, Japan
      name:Department of Cardiovascular Medicine, Tohoku University Hospital, 1-1, Seiryo, Aoba, Sendai, Japan
      name:Department of Brain Sciences, Imperial College London, London, UK
      name:University of Texas Health Science Center at Houston McGovern Medical School, Houston, USA
      name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
      name:Department of Biostatistics, Boston University School of Public Health, Boston, USA
      name:Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
      name:Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
      name:Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, USA
      name:Icelandic Heart Association, Kópavogur, Iceland
      name:Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan
      name:Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama City, Japan
      name:Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan
      name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
      name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
      name:Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
      name:Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
      name:Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
      name:Mathematics and Statistics, Murdoch University, Murdoch, Australia
      name:Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria
      name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
      name:GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
      name:Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
      name:Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
      name:Department of Public Health Sciences, University of California at Davis, Davis, USA
      name:Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center, Leiden, The Netherlands
      name:Pattern Recognition & Bioinformatics, Delft University of Technology, Delft, USA
      name:Leiden Computational Biology Centre, Leiden University Medical Centre, Leiden, The Netherlands
      name:Centre for Law and Genetics, Faculty of Law, University of Tasmania, Hobart, Australia
      name:Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
      name:Department of Internal Medicine, section of gerontology and geriatrics, Leiden University Medical Center, Leiden, The Netherlands
      name:Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
      name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
      name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
      name:Gottfried Schatz Research Center, Department of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
      name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
      name:Boston University and the NHLBI’s Framingham Heart Study, Boston, USA
      name:Department of Neurology, Boston University School of Medicine, Boston, USA
      name:University of Bordeaux, IMN, Bordeaux, France
      name:University of Bordeaux, IMN, Bordeaux, France
      name:University of Bordeaux, IMN, Bordeaux, France
      name:University of Bordeaux, IMN, Bordeaux, France
      name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
      name:Icelandic Heart Association, Kópavogur, Iceland
      name:Johns Hopkins University School of Medicine, Baltimore, USA
      name:University of Alabama at Birmingham School of Medicine, Birmingham, USA
      name:Department of Neurological Sciences, Rush University Medical Center, Chicago, USA
      name:Departments of Neurology and Psychiatry, University of Pittsburgh, Pittsburgh, USA
      name:Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
      name:Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, USA
      name:Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
      name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
      name:Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, UK
      name:Department of Radiology, Leiden University medical Center, Leiden, The Netherlands
      name:Queensland Brain Institute, The University of Queensland, St Lucia, Australia
      name:Centre for Advanced Imaging, The University of Queensland, St Lucia, Australia
      name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
      name:Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
      name:DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany
      name:Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
      name:Centre for Research in Mathematics and Data Science, Western Sydney University, Penrith, Australia
      name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
      name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
      name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
      name:Icelandic Heart Association, Kópavogur, Iceland
      name:Mayo Clinic, Rochester, USA
      name:University of Minnesota School of Public Health, Minneapolis, USA
      name:Department of Internal Medicine, Rush University Medical Center, Chicago, USA
      name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
      name:Department of Biostatistics, Boston University School of Public Health, Boston, USA
      name:Boston University and the NHLBI’s Framingham Heart Study, Boston, USA
      name:Department of Neurology, Boston University School of Medicine, Boston, USA
      name:Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
      name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
      name:Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center, Leiden, The Netherlands
      name:Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
      name:Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, Australia
      name:Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
      name:Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
      name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
      name:German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany
      name:Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
      name:Faculty of Applied Sciences, Delft University of Technology, Delft, USA
      name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
      name:University of Texas Health Science Center at Houston School of Public Health, Houston, USA
      name:Kaiser Permanente Division of Research, Oakland, USA
      name:Division of Nephrology and Hypertension, Mayo Clinic, Rochester, USA
      name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
      name:Department of Psychology, University of Edinburgh, Edinburgh, UK
      name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
      name:Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
      name:Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, UK
      name:The University of Texas at Austin Dell Medical School, Austin, USA
      name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
      name:Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
      name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
      name:Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, USA
      name:National Ageing Research Institute Royal Melbourne Hospital, Parkville, Australia
      name:Academic Unit for Psychiatry of Old Age, University of Melbourne, St George’s Hospital, Kew, Australia
      name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
      name:Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
      name:Inserm U1167, Lille, France
      name:Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France
      name:Brain and Mind Centre - The University of Sydney, Camperdown, Australia
      name:School of Medical Sciences, University of New South Wales, Sydney, Australia
      name:Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
      name:Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
      name:Department of Psychology, University of Edinburgh, Edinburgh, UK
      name:School of Medical Sciences, University of New South Wales, Sydney, Australia
      name:Neuroscience Research Australia, Randwick, Australia
      name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
      name:Dementia Centre for Research Collaboration, University of New South Wales, Sydney, Australia
      name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
      name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
      name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
      name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
      name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
      name:Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
      name:Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama City, Japan
      name:Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
      name:Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, USA
      name:Kaiser Permanente Washington Health Research Institute, Seattle, USA
      name:Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, USA
      name:Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, USA
      name:Program in Population and Medical Genetics, Broad Institute of MIT and Harvard, Cambridge, USA
      name:Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, USA
      name:Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Pediatrics at Harbor-UCLA Medical Center, Torrance, USA
      name:Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
      name:Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
      name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
      name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
      name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
      name:Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
      name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
      name:Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
      name:Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
      name:Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, USA
      name:Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
      name:Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia
      name:Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
      name:Section of Molecular Epidemiology, Biomedical Sciences, Leiden university Medical Center, Leiden, The Netherlands
      name:Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, USA
      name:Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan
      name:Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Tsurumi-ku, Yokohama City, Japan
      name:Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan
      name:University of Bordeaux, IMN, Bordeaux, France
      name:Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
      name:Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
      name:Row Fogo Centre for Ageing and The Brain, University of Edinburgh, Edinburgh, UK
      name:MRC UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
      name:Department of Neurology, Johns Hopkins School of Medicine, Baltimone, USA
      name:General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, USA
      name:Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
      name:Neuroscience Research Australia, Randwick, Australia
      name:Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
      name:German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany
      name:Gottfried Schatz Research Center, Department of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
      name:Nuffield Department of Population Health, University of Oxford, Oxford, UK
      name:Icelandic Heart Association, Kópavogur, Iceland
      name:University of Iceland, Faculty of Medicine, Reykjavík, Iceland
      name:Departments of Neurology and Epidemiology, University of Washington, Seattle, USA
      name:Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Bethesda, USA
      name:Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, USA
      name:University of McGill Genome Center, Montreal, Canada
      name:Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, USA
      name:Boston University and the NHLBI’s Framingham Heart Study, Boston, USA
      name:Department of Neurology, Boston University School of Medicine, Boston, USA
      name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
      name:CHU de Bordeaux, Pole de santé publique, Service d’information médicale, Bordeaux, France
      name:Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
      name:Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
      name:Department of Brain Sciences, Imperial College London, London, UK
      name:UK Dementia Research Institute, London, UK
      name:Data Science Institute, Imperial College London, London, UK
      name:University of Texas Health Science Center at Houston McGovern Medical School, Houston, USA
      name:University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France
      name:Department of Neurology, Boston University School of Medicine, Boston, USA
      name:Department of Neurology, CHU de Bordeaux, Bordeaux, France