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Keywords {🔍}

pubmed, article, google, scholar, alzheimers, dementia, disease, vascular, stroke, central, cognitive, cas, research, health, impairment, brain, association, national, world, risk, neurovascular, dois, neurol, dement, doijjalz, sci, cerebrovascular, factors, schneider, institute, aging, study, bennett, council, montine, contributions, corriveau, koroshetz, heart, disorders, res, jama, unit, american, global, alzheimer, privacy, cookies, function, content,

Topics {✒️}

gov/research/recommendations-nih-ad-research-summit-2015 month download article/chapter fr/archives-les-plans-alzheimer-2001-2005 int/mediacentre/factsheets/fs362/en/ gov/national-alzheimers-project-act community-dwelling older persons full article pdf disease-related dementias conference waddy & walter koroshetz dsm-iv-tr american psychiatric association jellinger ka countrywide strategic plans privacy choices/manage cookies molecular neurobiology aims advancing research priorities blood-brain barrier vascular cognitive impairment zlokovic bv article cellular de la sant� cerebral amyloid angiopathy association international conference research priority setting mild cognitive impairment vascular cognitive disorder world health organization preserve cognitive vitality vascular dysfunction contributes forgotten cell type cerebrovascular amyloid protein journal finder publish european economic area integrates diverse aspects snyder hm jack cr jr langer hf article log advance translational research related subjects vascular risk factors cerebrovascular disease increase conditions privacy policy modifiable risk factors shared risk factors similarly positive impact innate immune system individuals aged 65 years communities neurocognitive study public health priority

Questions {❓}

• Langa KM (2015) Is the risk of Alzheimer’s disease and dementia declining?
• Winkler EA, Sagare AP, Zlokovic BV (2014) The pericyte: a forgotten cell type with important implications for Alzheimer’s disease?

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         description:The World Health Organization reports that 47.5 million people are affected by dementia worldwide. With aging populations and 7.7 million new cases each year, the burden of illness due to dementia approaches crisis proportions. Despite significant advances in our understanding of the biology of Alzheimer’s disease (AD), the leading dementia diagnosis, the actual causes of dementia in affected individuals are unknown except for rare fully penetrant genetic forms. Evidence from epidemiology and pathology studies indicates that damage to the vascular system is associated with an increased risk of many types of dementia. Both Alzheimer’s pathology and cerebrovascular disease increase with age. How AD affects small blood vessel function and how vascular dysfunction contributes to the molecular pathology of Alzheimer’s are areas of intense research. The science of vascular contributions to cognitive impairment and dementia (VCID) integrates diverse aspects of biology and incorporates the roles of multiple cell types that support the function of neural tissue. Because of the proven ability to prevent and treat cardiovascular disease and hypertension with population benefits for heart and stroke outcomes, it is proposed that understanding and targeting the biological mechanisms of VCID can have a similarly positive impact on public health.
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